Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IKZF3 (IKAROS family zinc finger 3)

Identity

Alias_namesZNFN1A3
zinc finger protein, subfamily 1A, 3 (Aiolos)
IKAROS family zinc finger 3 (Aiolos)
Alias_symbol (synonym)Aiolos
Other aliasAIO
AIOLOS
HGNC (Hugo) IKZF3
LocusID (NCBI) 22806
Atlas_Id 46122
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39757715 and ends at 39864188 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC6 (17q21.2) / IKZF3 (17q12)CDK8 (13q12.13) / IKZF3 (17q12)ENDOV (17q25.3) / IKZF3 (17q12)
IKZF3 (17q12) / BCAS3 (17q23.2)IKZF3 (17q12) / ETV3 (1q23.1)IKZF3 (17q12) / RPL12 (9q33.3)
LUC7L3 (17q21.33) / IKZF3 (17q12)RAD54B (8q22.1) / IKZF3 (17q12)SKAP1 (17q21.32) / IKZF3 (17q12)
SMURF2 (17q23.3) / IKZF3 (17q12)VAPB (20q13.32) / IKZF3 (17q12)CDK8 13q12.13 / IKZF3 17q12
ENDOV 17q25.3 / IKZF3 17q12IKZF3 17q12 / BCAS3 17q23.2LUC7L3 17q21.33 / IKZF3 17q12
SKAP1 17q21.32 / IKZF3 17q12SMURF2 17q23.3 / IKZF3 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)IKZF3   13178
Cards
Entrez_Gene (NCBI)IKZF3  22806  IKAROS family zinc finger 3
AliasesAIO; AIOLOS; ZNFN1A3
GeneCards (Weizmann)IKZF3
Ensembl hg19 (Hinxton)ENSG00000161405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161405 [Gene_View]  chr17:39757715-39864188 [Contig_View]  IKZF3 [Vega]
ICGC DataPortalENSG00000161405
TCGA cBioPortalIKZF3
AceView (NCBI)IKZF3
Genatlas (Paris)IKZF3
WikiGenes22806
SOURCE (Princeton)IKZF3
Genetics Home Reference (NIH)IKZF3
Genomic and cartography
GoldenPath hg38 (UCSC)IKZF3  -     chr17:39757715-39864188 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IKZF3  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblIKZF3 - 17q12 [CytoView hg19]  IKZF3 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIIKZF3 [Mapview hg19]  IKZF3 [Mapview hg38]
OMIM606221   
Gene and transcription
Genbank (Entrez)AF086054 AF129512 AI866838 AJ292565 AJ292566
RefSeq transcript (Entrez)NM_001257408 NM_001257409 NM_001257410 NM_001257411 NM_001257412 NM_001257413 NM_001257414 NM_001284514 NM_001284515 NM_001284516 NM_012481 NM_183228 NM_183229 NM_183230 NM_183231 NM_183232
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IKZF3
Cluster EST : UnigeneHs.371680 [ NCBI ]
CGAP (NCI)Hs.371680
Alternative Splicing GalleryENSG00000161405
Gene ExpressionIKZF3 [ NCBI-GEO ]   IKZF3 [ EBI - ARRAY_EXPRESS ]   IKZF3 [ SEEK ]   IKZF3 [ MEM ]
Gene Expression Viewer (FireBrowse)IKZF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22806
GTEX Portal (Tissue expression)IKZF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKT9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKT9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKT9
Splice isoforms : SwissVarQ9UKT9
PhosPhoSitePlusQ9UKT9
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)IKZF3
DMDM Disease mutations22806
Blocks (Seattle)IKZF3
SuperfamilyQ9UKT9
Human Protein AtlasENSG00000161405
Peptide AtlasQ9UKT9
HPRD05869
IPIIPI00018923   IPI00465197   IPI01017985   IPI00465195   IPI00465194   IPI00883727   IPI01018345   IPI00215852   IPI00215853   IPI00215854   IPI00215855   IPI00215856   IPI00337565   IPI00797818   IPI00465198   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKT9
IntAct (EBI)Q9UKT9
FunCoupENSG00000161405
BioGRIDIKZF3
STRING (EMBL)IKZF3
ZODIACIKZF3
Ontologies - Pathways
QuickGOQ9UKT9
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  mesoderm development  regulation of B cell proliferation  B cell activation  identical protein binding  protein homodimerization activity  regulation of apoptotic process  sequence-specific DNA binding  transcription regulatory region DNA binding  regulation of B cell differentiation  regulation of lymphocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  protein heterodimerization activity  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  mesoderm development  regulation of B cell proliferation  B cell activation  identical protein binding  protein homodimerization activity  regulation of apoptotic process  sequence-specific DNA binding  transcription regulatory region DNA binding  regulation of B cell differentiation  regulation of lymphocyte differentiation  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  protein heterodimerization activity  
Pathways : BIOCARTAIL-2 Receptor Beta Chain in T cell Activation [Genes]   
NDEx NetworkIKZF3
Atlas of Cancer Signalling NetworkIKZF3
Wikipedia pathwaysIKZF3
Orthology - Evolution
OrthoDB22806
GeneTree (enSembl)ENSG00000161405
Phylogenetic Trees/Animal Genes : TreeFamIKZF3
HOVERGENQ9UKT9
HOGENOMQ9UKT9
Homologs : HomoloGeneIKZF3
Homology/Alignments : Family Browser (UCSC)IKZF3
Gene fusions - Rearrangements
Fusion : MitelmanCDC6/IKZF3 [17q21.2/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanCDK8/IKZF3 [13q12.13/17q12]  [t(13;17)(q12;q12)]  
Fusion : MitelmanENDOV/IKZF3 [17q25.3/17q12]  [t(17;17)(q12;q25)]  
Fusion : MitelmanIKZF3/BCAS3 [17q12/17q23.2]  [t(17;17)(q12;q23)]  
Fusion : MitelmanIKZF3/ETV3 [17q12/1q23.1]  [t(1;17)(q23;q12)]  
Fusion : MitelmanLUC7L3/IKZF3 [17q21.33/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanSKAP1/IKZF3 [17q21.32/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanVAPB/IKZF3 [20q13.32/17q12]  [t(17;20)(q12;q13)]  
Fusion: TCGACDK8 13q12.13 IKZF3 17q12 BRCA
Fusion: TCGAENDOV 17q25.3 IKZF3 17q12 BRCA
Fusion: TCGAIKZF3 17q12 BCAS3 17q23.2 BRCA
Fusion: TCGALUC7L3 17q21.33 IKZF3 17q12 BRCA
Fusion: TCGASKAP1 17q21.32 IKZF3 17q12 BRCA
Fusion: TCGASMURF2 17q23.3 IKZF3 17q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIKZF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IKZF3
dbVarIKZF3
ClinVarIKZF3
1000_GenomesIKZF3 
Exome Variant ServerIKZF3
ExAC (Exome Aggregation Consortium)IKZF3 (select the gene name)
Genetic variants : HAPMAP22806
Genomic Variants (DGV)IKZF3 [DGVbeta]
DECIPHERIKZF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIKZF3 
Mutations
ICGC Data PortalIKZF3 
TCGA Data PortalIKZF3 
Broad Tumor PortalIKZF3
OASIS PortalIKZF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIKZF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIKZF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IKZF3
DgiDB (Drug Gene Interaction Database)IKZF3
DoCM (Curated mutations)IKZF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IKZF3 (select a term)
intoGenIKZF3
Cancer3DIKZF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606221   
Orphanet10899   
MedgenIKZF3
Genetic Testing Registry IKZF3
NextProtQ9UKT9 [Medical]
TSGene22806
GENETestsIKZF3
Target ValidationIKZF3
Huge Navigator IKZF3 [HugePedia]
snp3D : Map Gene to Disease22806
BioCentury BCIQIKZF3
ClinGenIKZF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22806
Chemical/Pharm GKB GenePA37750
Clinical trialIKZF3
Miscellaneous
canSAR (ICR)IKZF3 (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIKZF3
EVEXIKZF3
GoPubMedIKZF3
iHOPIKZF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:15 CEST 2017

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