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IL10 (interleukin 10)

Identity

Other namesCSIF
GVHDS
IL-10
IL10A
TGIF
HGNC (Hugo) IL10
LocusID (NCBI) 3586
Location 1q32.1
Location_base_pair Starts at 206940948 and ends at 206945839 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IL10   5962
Cards
Entrez_Gene (NCBI)IL10  3586  interleukin 10
GeneCards (Weizmann)IL10
Ensembl (Hinxton)ENSG00000136634 [Gene_View]  chr1:206940948-206945839 [Contig_View]  IL10 [Vega]
ICGC DataPortalENSG00000136634
cBioPortalIL10
AceView (NCBI)IL10
Genatlas (Paris)IL10
WikiGenes3586
SOURCE (Princeton)NM_000572
Genomic and cartography
GoldenPath (UCSC)IL10  -  1q32.1   chr1:206940948-206945839 -  1q32.1   [Description]    (hg19-Feb_2009)
EnsemblIL10 - 1q32.1 [CytoView]
Mapping of homologs : NCBIIL10 [Mapview]
OMIM124092   180300   609423   614395   
Gene and transcription
Genbank (Entrez)AF043333 AY029171 BC022315 BC104252 BC104253
RefSeq transcript (Entrez)NM_000572
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_012088 NT_004487 NW_001838536 NW_004929294
Consensus coding sequences : CCDS (NCBI)IL10
Cluster EST : UnigeneHs.193717 [ NCBI ]
CGAP (NCI)Hs.193717
Alternative Splicing : Fast-db (Paris)GSHG0002911
Alternative Splicing GalleryENSG00000136634
Gene ExpressionIL10 [ NCBI-GEO ]     IL10 [ SEEK ]   IL10 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22301 (Uniprot)
NextProtP22301  [Medical]
With graphics : InterProP22301
Splice isoforms : SwissVarP22301 (Swissvar)
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_10 (PS00520)   
Domains : Interpro (EBI)4_helix_cytokine-like_core [organisation]   4_helix_cytokine_core [organisation]   IL-10 [organisation]   IL-10/19/20/24/26_fam [organisation]   IL-10_CS [organisation]  
Related proteins : CluSTrP22301
Domain families : Pfam (Sanger)IL10 (PF00726)   
Domain families : Pfam (NCBI)pfam00726   
Domain families : Smart (EMBL)IL10 (SM00188)  
DMDM Disease mutations3586
Blocks (Seattle)P22301
PDB (SRS)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (PDBSum)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (IMB)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (RSDB)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
Human Protein AtlasENSG00000136634 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP22301
HPRD00495
IPIIPI00026102   
Protein Interaction databases
DIP (DOE-UCLA)P22301
IntAct (EBI)P22301
FunCoupENSG00000136634
BioGRIDIL10
InParanoidP22301
Interologous Interaction database P22301
IntegromeDBIL10
STRING (EMBL)IL10
Ontologies - Pathways
Ontology : AmiGOresponse to molecule of bacterial origin  negative regulation of cytokine secretion involved in immune response  negative regulation of chronic inflammatory response to antigenic stimulus  positive regulation of B cell apoptotic process  cytokine activity  interleukin-10 receptor binding  extracellular space  inflammatory response  cytoplasmic sequestering of NF-kappaB  cell-cell signaling  growth factor activity  regulation of gene expression  response to activity  response to inactivity  hemopoiesis  B cell differentiation  leukocyte chemotaxis  negative regulation of myeloid dendritic cell activation  negative regulation of B cell proliferation  negative regulation of interferon-gamma production  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  receptor biosynthetic process  response to insulin  response to carbon monoxide  type 2 immune response  B cell proliferation  negative regulation of T cell proliferation  response to drug  negative regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  negative regulation of apoptotic process  negative regulation of growth of symbiont in host  negative regulation of nitric oxide biosynthetic process  regulation of isotype switching  negative regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  negative regulation of interferon-alpha biosynthetic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of cytokine secretion  negative regulation of membrane protein ectodomain proteolysis  positive regulation of sequence-specific DNA binding transcription factor activity  response to glucocorticoid  regulation of sensory perception of pain  branching involved in labyrinthine layer morphogenesis  cellular response to lipopolysaccharide  cellular response to estradiol stimulus  
Ontology : EGO-EBIresponse to molecule of bacterial origin  negative regulation of cytokine secretion involved in immune response  negative regulation of chronic inflammatory response to antigenic stimulus  positive regulation of B cell apoptotic process  cytokine activity  interleukin-10 receptor binding  extracellular space  inflammatory response  cytoplasmic sequestering of NF-kappaB  cell-cell signaling  growth factor activity  regulation of gene expression  response to activity  response to inactivity  hemopoiesis  B cell differentiation  leukocyte chemotaxis  negative regulation of myeloid dendritic cell activation  negative regulation of B cell proliferation  negative regulation of interferon-gamma production  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  receptor biosynthetic process  response to insulin  response to carbon monoxide  type 2 immune response  B cell proliferation  negative regulation of T cell proliferation  response to drug  negative regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  negative regulation of apoptotic process  negative regulation of growth of symbiont in host  negative regulation of nitric oxide biosynthetic process  regulation of isotype switching  negative regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  negative regulation of interferon-alpha biosynthetic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of cytokine secretion  negative regulation of membrane protein ectodomain proteolysis  positive regulation of sequence-specific DNA binding transcription factor activity  response to glucocorticoid  regulation of sensory perception of pain  branching involved in labyrinthine layer morphogenesis  cellular response to lipopolysaccharide  cellular response to estradiol stimulus  
Pathways : BIOCARTAIL-10 Anti-inflammatory Signaling Pathway [Genes]    Antigen Dependent B Cell Activation [Genes]    Cytokine Network [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Cytokines and Inflammatory Response [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    FoxO signaling pathway    Jak-STAT signaling pathway    T cell receptor signaling pathway    Intestinal immune network for IgA production    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Malaria    Toxoplasmosis    Amoebiasis    Staphylococcus aureus infection    Tuberculosis    Epstein-Barr virus infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Allograft rejection   
Protein Interaction DatabaseIL10
Wikipedia pathwaysIL10
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IL10
snp3D : Map Gene to Disease3586
SNP (GeneSNP Utah)IL10
SNP : HGBaseIL10
Genetic variants : HAPMAPIL10
Exome VariantIL10
1000_GenomesIL10 
ICGC programENSG00000136634 
Somatic Mutations in Cancer : COSMICIL10 
CONAN: Copy Number AnalysisIL10 
Mutations and Diseases : HGMDIL10
Mutations and Diseases : intOGenIL10
Genomic VariantsIL10  IL10 [DGVbeta]
dbVarIL10
ClinVarIL10
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM124092    180300    609423    614395   
MedgenIL10
GENETestsIL10
Disease Genetic AssociationIL10
Huge Navigator IL10 [HugePedia]  IL10 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIL10
Homology/Alignments : Family Browser (UCSC)IL10
Phylogenetic Trees/Animal Genes : TreeFamIL10
Chemical/Protein Interactions : CTD3586
Chemical/Pharm GKB GenePA29778
Clinical trialIL10
Cancer Resource (Charite)ENSG00000136634
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineIL10
iHOPIL10
OncoSearchIL10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:50:41 CEST 2014

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