Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL10 (interleukin 10)

Identity

Alias_symbol (synonym)CSIF
TGIF
IL10A
IL-10
Other aliasGVHDS
HGNC (Hugo) IL10
LocusID (NCBI) 3586
Atlas_Id 40939
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206767603 and ends at 206772494 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Multiple Myeloma

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Gastric Tumors: an overview

External links

Nomenclature
HGNC (Hugo)IL10   5962
Cards
Entrez_Gene (NCBI)IL10  3586  interleukin 10
AliasesCSIF; GVHDS; IL-10; IL10A; 
TGIF
GeneCards (Weizmann)IL10
Ensembl hg19 (Hinxton)ENSG00000136634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136634 [Gene_View]  chr1:206767603-206772494 [Contig_View]  IL10 [Vega]
ICGC DataPortalENSG00000136634
TCGA cBioPortalIL10
AceView (NCBI)IL10
Genatlas (Paris)IL10
WikiGenes3586
SOURCE (Princeton)IL10
Genetics Home Reference (NIH)IL10
Genomic and cartography
GoldenPath hg38 (UCSC)IL10  -     chr1:206767603-206772494 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL10  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblIL10 - 1q32.1 [CytoView hg19]  IL10 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIIL10 [Mapview hg19]  IL10 [Mapview hg38]
OMIM124092   180300   609423   614395   
Gene and transcription
Genbank (Entrez)AF043333 AY029171 BC022315 BC104252 BC104253
RefSeq transcript (Entrez)NM_000572
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL10
Cluster EST : UnigeneHs.193717 [ NCBI ]
CGAP (NCI)Hs.193717
Alternative Splicing GalleryENSG00000136634
Gene ExpressionIL10 [ NCBI-GEO ]   IL10 [ EBI - ARRAY_EXPRESS ]   IL10 [ SEEK ]   IL10 [ MEM ]
Gene Expression Viewer (FireBrowse)IL10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3586
GTEX Portal (Tissue expression)IL10
Human Protein AtlasENSG00000136634-IL10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22301   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22301  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22301
Splice isoforms : SwissVarP22301
PhosPhoSitePlusP22301
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_10 (PS00520)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    IL-10    IL-10/19/20/22/24/26_fam    IL-10_CS   
Domain families : Pfam (Sanger)IL10 (PF00726)   
Domain families : Pfam (NCBI)pfam00726   
Domain families : Smart (EMBL)IL10 (SM00188)  
Conserved Domain (NCBI)IL10
DMDM Disease mutations3586
Blocks (Seattle)IL10
PDB (SRS)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (PDBSum)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (IMB)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (RSDB)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
Structural Biology KnowledgeBase1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
SCOP (Structural Classification of Proteins)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
CATH (Classification of proteins structures)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
SuperfamilyP22301
Human Protein Atlas [tissue]ENSG00000136634-IL10 [tissue]
Peptide AtlasP22301
HPRD00495
IPIIPI00026102   
Protein Interaction databases
DIP (DOE-UCLA)P22301
IntAct (EBI)P22301
FunCoupENSG00000136634
BioGRIDIL10
STRING (EMBL)IL10
ZODIACIL10
Ontologies - Pathways
QuickGOP22301
Ontology : AmiGOpositive regulation of endothelial cell proliferation  response to molecule of bacterial origin  negative regulation of cytokine secretion involved in immune response  negative regulation of chronic inflammatory response to antigenic stimulus  positive regulation of B cell apoptotic process  cytokine activity  interleukin-10 receptor binding  protein binding  extracellular region  extracellular space  inflammatory response  cytoplasmic sequestering of NF-kappaB  aging  growth factor activity  negative regulation of cell proliferation  regulation of gene expression  response to activity  response to inactivity  cytokine-mediated signaling pathway  hemopoiesis  B cell differentiation  leukocyte chemotaxis  negative regulation of myeloid dendritic cell activation  negative regulation of B cell proliferation  negative regulation of interferon-gamma production  negative regulation of interleukin-1 production  negative regulation of interleukin-12 production  negative regulation of interleukin-18 production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  receptor biosynthetic process  response to insulin  negative regulation of heterotypic cell-cell adhesion  positive regulation of heterotypic cell-cell adhesion  response to carbon monoxide  interleukin-12-mediated signaling pathway  cellular response to hepatocyte growth factor stimulus  type 2 immune response  B cell proliferation  negative regulation of T cell proliferation  negative regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  defense response to protozoan  positive regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of growth of symbiont in host  negative regulation of nitric oxide biosynthetic process  regulation of isotype switching  negative regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  negative regulation of interferon-alpha biosynthetic process  positive regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of mitotic cell cycle  positive regulation of transcription by RNA polymerase II  positive regulation of cytokine secretion  negative regulation of inflammatory response  regulation of synapse organization  negative regulation of membrane protein ectodomain proteolysis  positive regulation of DNA binding transcription factor activity  response to glucocorticoid  negative regulation of cytokine activity  branching involved in labyrinthine layer morphogenesis  cellular response to lipopolysaccharide  cellular response to estradiol stimulus  negative regulation of chemokine (C-C motif) ligand 5 production  endothelial cell apoptotic process  liver regeneration  regulation of response to wounding  negative regulation of hydrogen peroxide-induced neuron death  regulation of complement-dependent cytotoxicity  negative regulation of sensory perception of pain  negative regulation of vascular smooth muscle cell proliferation  positive regulation of vascular smooth muscle cell proliferation  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  response to molecule of bacterial origin  negative regulation of cytokine secretion involved in immune response  negative regulation of chronic inflammatory response to antigenic stimulus  positive regulation of B cell apoptotic process  cytokine activity  interleukin-10 receptor binding  protein binding  extracellular region  extracellular space  inflammatory response  cytoplasmic sequestering of NF-kappaB  aging  growth factor activity  negative regulation of cell proliferation  regulation of gene expression  response to activity  response to inactivity  cytokine-mediated signaling pathway  hemopoiesis  B cell differentiation  leukocyte chemotaxis  negative regulation of myeloid dendritic cell activation  negative regulation of B cell proliferation  negative regulation of interferon-gamma production  negative regulation of interleukin-1 production  negative regulation of interleukin-12 production  negative regulation of interleukin-18 production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  receptor biosynthetic process  response to insulin  negative regulation of heterotypic cell-cell adhesion  positive regulation of heterotypic cell-cell adhesion  response to carbon monoxide  interleukin-12-mediated signaling pathway  cellular response to hepatocyte growth factor stimulus  type 2 immune response  B cell proliferation  negative regulation of T cell proliferation  negative regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  defense response to protozoan  positive regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of growth of symbiont in host  negative regulation of nitric oxide biosynthetic process  regulation of isotype switching  negative regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  negative regulation of interferon-alpha biosynthetic process  positive regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of mitotic cell cycle  positive regulation of transcription by RNA polymerase II  positive regulation of cytokine secretion  negative regulation of inflammatory response  regulation of synapse organization  negative regulation of membrane protein ectodomain proteolysis  positive regulation of DNA binding transcription factor activity  response to glucocorticoid  negative regulation of cytokine activity  branching involved in labyrinthine layer morphogenesis  cellular response to lipopolysaccharide  cellular response to estradiol stimulus  negative regulation of chemokine (C-C motif) ligand 5 production  endothelial cell apoptotic process  liver regeneration  regulation of response to wounding  negative regulation of hydrogen peroxide-induced neuron death  regulation of complement-dependent cytotoxicity  negative regulation of sensory perception of pain  negative regulation of vascular smooth muscle cell proliferation  positive regulation of vascular smooth muscle cell proliferation  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAIL-10 Anti-inflammatory Signaling Pathway [Genes]    Antigen Dependent B Cell Activation [Genes]    Cytokine Network [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Cytokines and Inflammatory Response [Genes]   
Pathways : KEGGJak-STAT signaling pathway    T cell receptor signaling pathway    Cytokine-cytokine receptor interaction   
NDEx NetworkIL10
Atlas of Cancer Signalling NetworkIL10
Wikipedia pathwaysIL10
Orthology - Evolution
OrthoDB3586
GeneTree (enSembl)ENSG00000136634
Phylogenetic Trees/Animal Genes : TreeFamIL10
HOVERGENP22301
HOGENOMP22301
Homologs : HomoloGeneIL10
Homology/Alignments : Family Browser (UCSC)IL10
Gene fusions - Rearrangements
Fusion : QuiverIL10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL10
dbVarIL10
ClinVarIL10
1000_GenomesIL10 
Exome Variant ServerIL10
ExAC (Exome Aggregation Consortium)ENSG00000136634
GNOMAD BrowserENSG00000136634
Genetic variants : HAPMAP3586
Genomic Variants (DGV)IL10 [DGVbeta]
DECIPHERIL10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL10 
Mutations
ICGC Data PortalIL10 
TCGA Data PortalIL10 
Broad Tumor PortalIL10
OASIS PortalIL10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch IL10
DgiDB (Drug Gene Interaction Database)IL10
DoCM (Curated mutations)IL10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL10 (select a term)
intoGenIL10
Cancer3DIL10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124092    180300    609423    614395   
Orphanet703    19277   
DisGeNETIL10
MedgenIL10
Genetic Testing Registry IL10
NextProtP22301 [Medical]
TSGene3586
GENETestsIL10
Target ValidationIL10
Huge Navigator IL10 [HugePedia]
snp3D : Map Gene to Disease3586
BioCentury BCIQIL10
ClinGenIL10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3586
Chemical/Pharm GKB GenePA29778
Clinical trialIL10
Miscellaneous
canSAR (ICR)IL10 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL10
EVEXIL10
GoPubMedIL10
iHOPIL10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 14 11:52:33 CEST 2018
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