Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IL10 (interleukin 10)

Identity

Alias (NCBI)CSIF
GVHDS
IL-10
IL10A
TGIF
HGNC (Hugo) IL10
HGNC Alias symbCSIF
TGIF
IL10A
IL-10
HGNC Alias namecytokine synthesis inhibitory factor
 T-cell growth inhibitory factor
LocusID (NCBI) 3586
Atlas_Id 40939
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 206767602 and ends at 206772494 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Breast implant-associated anaplastic large cell lymphoma
Multiple Myeloma
t(14;16)(q32;q23) IGH/MAF

External links

 

Nomenclature
HGNC (Hugo)IL10   5962
Cards
Entrez_Gene (NCBI)IL10    interleukin 10
AliasesCSIF; GVHDS; IL-10; IL10A; 
TGIF
GeneCards (Weizmann)IL10
Ensembl hg19 (Hinxton)ENSG00000136634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136634 [Gene_View]  ENSG00000136634 [Sequence]  chr1:206767602-206772494 [Contig_View]  IL10 [Vega]
ICGC DataPortalENSG00000136634
TCGA cBioPortalIL10
AceView (NCBI)IL10
Genatlas (Paris)IL10
SOURCE (Princeton)IL10
Genetics Home Reference (NIH)IL10
Genomic and cartography
GoldenPath hg38 (UCSC)IL10  -     chr1:206767602-206772494 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL10  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathIL10 - 1q32.1 [CytoView hg19]  IL10 - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000136634
Genome Data Viewer NCBIIL10 [Mapview hg19]  
OMIM124092   180300   609423   614395   
Gene and transcription
Genbank (Entrez)AF043333 AY029171 BC022315 BC104252 BC104253
RefSeq transcript (Entrez)NM_000572 NM_001382624
Consensus coding sequences : CCDS (NCBI)IL10
Gene ExpressionIL10 [ NCBI-GEO ]   IL10 [ EBI - ARRAY_EXPRESS ]   IL10 [ SEEK ]   IL10 [ MEM ]
Gene Expression Viewer (FireBrowse)IL10 [ Firebrowse - Broad ]
GenevisibleExpression of IL10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3586
GTEX Portal (Tissue expression)IL10
Human Protein AtlasENSG00000136634-IL10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22301   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22301  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22301
PhosPhoSitePlusP22301
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_10 (PS00520)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-10    IL-10/19/20/22/24/26_fam    IL-10_CS   
Domain families : Pfam (Sanger)IL10 (PF00726)   
Domain families : Pfam (NCBI)pfam00726   
Domain families : Smart (EMBL)IL10 (SM00188)  
Conserved Domain (NCBI)IL10
PDB (RSDB)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB Europe1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (PDBSum)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
PDB (IMB)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
Structural Biology KnowledgeBase1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
SCOP (Structural Classification of Proteins)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
CATH (Classification of proteins structures)1ILK    1INR    1J7V    1LK3    1Y6K    2H24    2ILK   
SuperfamilyP22301
AlphaFold pdb e-kbP22301   
Human Protein Atlas [tissue]ENSG00000136634-IL10 [tissue]
HPRD00495
Protein Interaction databases
DIP (DOE-UCLA)P22301
IntAct (EBI)P22301
BioGRIDIL10
STRING (EMBL)IL10
ZODIACIL10
Ontologies - Pathways
QuickGOP22301
Ontology : AmiGOnegative regulation of cytokine production  positive regulation of cytokine production  positive regulation of endothelial cell proliferation  response to molecule of bacterial origin  positive regulation of immunoglobulin production  negative regulation of cytokine production involved in immune response  negative regulation of inflammatory response to antigenic stimulus  negative regulation of chronic inflammatory response to antigenic stimulus  positive regulation of B cell apoptotic process  cytokine activity  interleukin-10 receptor binding  protein binding  extracellular region  extracellular space  cytoplasmic sequestering of NF-kappaB  aging  growth factor activity  negative regulation of cell population proliferation  regulation of gene expression  negative regulation of autophagy  response to activity  response to inactivity  cytokine-mediated signaling pathway  hemopoiesis  B cell differentiation  leukocyte chemotaxis  negative regulation of myeloid dendritic cell activation  negative regulation of B cell proliferation  negative regulation of interferon-alpha production  negative regulation of interferon-gamma production  negative regulation of interleukin-1 production  negative regulation of interleukin-12 production  negative regulation of interleukin-18 production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  response to insulin  negative regulation of heterotypic cell-cell adhesion  positive regulation of heterotypic cell-cell adhesion  response to carbon monoxide  interleukin-12-mediated signaling pathway  cellular response to hepatocyte growth factor stimulus  type 2 immune response  B cell proliferation  negative regulation of T cell proliferation  response to drug  defense response to bacterium  defense response to protozoan  positive regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  negative regulation of nitric oxide biosynthetic process  regulation of isotype switching  negative regulation of MHC class II biosynthetic process  negative regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of mitotic cell cycle  positive regulation of receptor signaling pathway via JAK-STAT  protein dimerization activity  negative regulation of inflammatory response  negative regulation of inflammatory response  regulation of synapse organization  negative regulation of membrane protein ectodomain proteolysis  positive regulation of DNA-binding transcription factor activity  response to glucocorticoid  negative regulation of cytokine activity  branching involved in labyrinthine layer morphogenesis  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to estradiol stimulus  negative regulation of chemokine (C-C motif) ligand 5 production  endothelial cell apoptotic process  liver regeneration  positive regulation of plasma cell differentiation  positive regulation of pri-miRNA transcription by RNA polymerase II  regulation of response to wounding  negative regulation of hydrogen peroxide-induced neuron death  regulation of complement-dependent cytotoxicity  positive regulation of sprouting angiogenesis  negative regulation of sensory perception of pain  negative regulation of vascular associated smooth muscle cell proliferation  positive regulation of vascular associated smooth muscle cell proliferation  positive regulation of signaling receptor activity  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBInegative regulation of cytokine production  positive regulation of cytokine production  positive regulation of endothelial cell proliferation  response to molecule of bacterial origin  positive regulation of immunoglobulin production  negative regulation of cytokine production involved in immune response  negative regulation of inflammatory response to antigenic stimulus  negative regulation of chronic inflammatory response to antigenic stimulus  positive regulation of B cell apoptotic process  cytokine activity  interleukin-10 receptor binding  protein binding  extracellular region  extracellular space  cytoplasmic sequestering of NF-kappaB  aging  growth factor activity  negative regulation of cell population proliferation  regulation of gene expression  negative regulation of autophagy  response to activity  response to inactivity  cytokine-mediated signaling pathway  hemopoiesis  B cell differentiation  leukocyte chemotaxis  negative regulation of myeloid dendritic cell activation  negative regulation of B cell proliferation  negative regulation of interferon-alpha production  negative regulation of interferon-gamma production  negative regulation of interleukin-1 production  negative regulation of interleukin-12 production  negative regulation of interleukin-18 production  negative regulation of interleukin-6 production  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  negative regulation of tumor necrosis factor production  response to insulin  negative regulation of heterotypic cell-cell adhesion  positive regulation of heterotypic cell-cell adhesion  response to carbon monoxide  interleukin-12-mediated signaling pathway  cellular response to hepatocyte growth factor stimulus  type 2 immune response  B cell proliferation  negative regulation of T cell proliferation  response to drug  defense response to bacterium  defense response to protozoan  positive regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of neuron apoptotic process  negative regulation of nitric oxide biosynthetic process  regulation of isotype switching  negative regulation of MHC class II biosynthetic process  negative regulation of MHC class II biosynthetic process  positive regulation of MHC class II biosynthetic process  positive regulation of cell cycle  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  negative regulation of mitotic cell cycle  positive regulation of receptor signaling pathway via JAK-STAT  protein dimerization activity  negative regulation of inflammatory response  negative regulation of inflammatory response  regulation of synapse organization  negative regulation of membrane protein ectodomain proteolysis  positive regulation of DNA-binding transcription factor activity  response to glucocorticoid  negative regulation of cytokine activity  branching involved in labyrinthine layer morphogenesis  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to estradiol stimulus  negative regulation of chemokine (C-C motif) ligand 5 production  endothelial cell apoptotic process  liver regeneration  positive regulation of plasma cell differentiation  positive regulation of pri-miRNA transcription by RNA polymerase II  regulation of response to wounding  negative regulation of hydrogen peroxide-induced neuron death  regulation of complement-dependent cytotoxicity  positive regulation of sprouting angiogenesis  negative regulation of sensory perception of pain  negative regulation of vascular associated smooth muscle cell proliferation  positive regulation of vascular associated smooth muscle cell proliferation  positive regulation of signaling receptor activity  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAIL-10 Anti-inflammatory Signaling Pathway [Genes]    Antigen Dependent B Cell Activation [Genes]    Cytokine Network [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Cytokines and Inflammatory Response [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    FoxO signaling pathway    Jak-STAT signaling pathway    T cell receptor signaling pathway    Intestinal immune network for IgA production    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Malaria    Toxoplasmosis    Amoebiasis    Staphylococcus aureus infection    Tuberculosis    Epstein-Barr virus infection    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Systemic lupus erythematosus    Allograft rejection   
NDEx NetworkIL10
Atlas of Cancer Signalling NetworkIL10
Wikipedia pathwaysIL10
Orthology - Evolution
OrthoDB3586
GeneTree (enSembl)ENSG00000136634
Phylogenetic Trees/Animal Genes : TreeFamIL10
Homologs : HomoloGeneIL10
Homology/Alignments : Family Browser (UCSC)IL10
Gene fusions - Rearrangements
Fusion : QuiverIL10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL10
dbVarIL10
ClinVarIL10
MonarchIL10
1000_GenomesIL10 
Exome Variant ServerIL10
GNOMAD BrowserENSG00000136634
Varsome BrowserIL10
ACMGIL10 variants
VarityP22301
Genomic Variants (DGV)IL10 [DGVbeta]
DECIPHERIL10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL10 
Mutations
ICGC Data PortalIL10 
TCGA Data PortalIL10 
Broad Tumor PortalIL10
OASIS PortalIL10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIL10
Mutations and Diseases : HGMDIL10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIL10
DgiDB (Drug Gene Interaction Database)IL10
DoCM (Curated mutations)IL10
CIViC (Clinical Interpretations of Variants in Cancer)IL10
Cancer3DIL10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124092    180300    609423    614395   
Orphanet703    19277   
DisGeNETIL10
MedgenIL10
Genetic Testing Registry IL10
NextProtP22301 [Medical]
GENETestsIL10
Target ValidationIL10
Huge Navigator IL10 [HugePedia]
ClinGenIL10
Clinical trials, drugs, therapy
MyCancerGenomeIL10
Protein Interactions : CTDIL10
Pharm GKB GenePA29778
PharosP22301
Clinical trialIL10
Miscellaneous
canSAR (ICR)IL10
HarmonizomeIL10
DataMed IndexIL10
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIL10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:13:41 CEST 2021
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