IL11 (interleukin 11)

2007-02-01 Affiliation

Identity

HGNC

IL11

LOCATION

19q13.42

LOCUSID

3589

ALIAS

AGIF,IL-11

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3589
MIM: 147681
HGNC: 5966
Ensembl: ENSG00000095752

Variants:

dbSNP: 3589
ClinVar: 3589
TCGA: ENSG00000095752
COSMIC: IL11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000095752	ENST00000264563	P20809
ENSG00000095752	ENST00000264563	A8K3F7
ENSG00000095752	ENST00000585513	P20809
ENSG00000095752	ENST00000585513	A8K3F7
ENSG00000095752	ENST00000587093	K7ESD5
ENSG00000095752	ENST00000590625	P20809

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Hematopoietic cell lineage	KEGG	ko04640
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Hematopoietic cell lineage	KEGG	hsa04640
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-6 family signaling	REACTOME	R-HSA-6783589
IL-6-type cytokine receptor ligand interactions	REACTOME	R-HSA-6788467

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10074	escitalopram	Chemical	ClinicalAnnotation	associated	PD	23142150
PA447278	Depression	Disease	ClinicalAnnotation	associated	PD	23142150
PA449015	citalopram	Chemical	MultilinkAnnotation	associated		25916525

References

Pubmed ID	Year	Title	Citations
12584029	2003	Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism.	102
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
20360315	2010	Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.	87
23340433	2013	MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.	82
18490653	2008	cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.	65
29160304	2017	IL-11 is a crucial determinant of cardiovascular fibrosis.	57
12819039	2003	Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation.	47
21741611	2011	Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth.	47
22289923	2012	Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation.	40
15025215	2004	Interleukin-11 and IL-17 and the pathogenesis of periodontal disease.	38

Citation

Dessen P

IL11 (interleukin 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45534/il11