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IL11 (interleukin 11)

Identity

Alias_symbol (synonym)IL-11
AGIF
Other alias
HGNC (Hugo) IL11
LocusID (NCBI) 3589
Atlas_Id 45534
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55364382 and ends at 55370463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AGAP2 (12q14.1) / IL11 (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IL11   5966
Cards
Entrez_Gene (NCBI)IL11  3589  interleukin 11
AliasesAGIF; IL-11
GeneCards (Weizmann)IL11
Ensembl hg19 (Hinxton)ENSG00000095752 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095752 [Gene_View]  chr19:55364382-55370463 [Contig_View]  IL11 [Vega]
ICGC DataPortalENSG00000095752
TCGA cBioPortalIL11
AceView (NCBI)IL11
Genatlas (Paris)IL11
WikiGenes3589
SOURCE (Princeton)IL11
Genetics Home Reference (NIH)IL11
Genomic and cartography
GoldenPath hg38 (UCSC)IL11  -     chr19:55364382-55370463 -  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL11  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblIL11 - 19q13.42 [CytoView hg19]  IL11 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIIL11 [Mapview hg19]  IL11 [Mapview hg38]
OMIM147681   
Gene and transcription
Genbank (Entrez)AK290572 AK298973 AK315294 BC012506 BF055151
RefSeq transcript (Entrez)NM_000641 NM_001267718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL11
Cluster EST : UnigeneHs.467304 [ NCBI ]
CGAP (NCI)Hs.467304
Alternative Splicing GalleryENSG00000095752
Gene ExpressionIL11 [ NCBI-GEO ]   IL11 [ EBI - ARRAY_EXPRESS ]   IL11 [ SEEK ]   IL11 [ MEM ]
Gene Expression Viewer (FireBrowse)IL11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3589
GTEX Portal (Tissue expression)IL11
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20809   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20809  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20809
Splice isoforms : SwissVarP20809
PhosPhoSitePlusP20809
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    IL-11    IL-11_mml   
Domain families : Pfam (Sanger)IL11 (PF07400)   
Domain families : Pfam (NCBI)pfam07400   
Conserved Domain (NCBI)IL11
DMDM Disease mutations3589
Blocks (Seattle)IL11
PDB (SRS)4MHL   
PDB (PDBSum)4MHL   
PDB (IMB)4MHL   
PDB (RSDB)4MHL   
Structural Biology KnowledgeBase4MHL   
SCOP (Structural Classification of Proteins)4MHL   
CATH (Classification of proteins structures)4MHL   
SuperfamilyP20809
Human Protein AtlasENSG00000095752
Peptide AtlasP20809
HPRD00980
IPIIPI00025820   
Protein Interaction databases
DIP (DOE-UCLA)P20809
IntAct (EBI)P20809
FunCoup=/TDžENSG00000095752
BioGRIDIL11
STRING (EMBL)IL11
ZODIACIL11
Ontologies - Pathways
QuickGOP20809
Ontology : AmiGOcytokine activity  interleukin-11 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  cytoplasm  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  B cell differentiation  megakaryocyte differentiation  positive regulation of peptidyl-serine phosphorylation  positive regulation of MAPK cascade  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  negative regulation of hormone secretion  positive regulation of peptidyl-tyrosine phosphorylation  regulation of complement-dependent cytotoxicity  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIcytokine activity  interleukin-11 receptor binding  protein binding  extracellular region  extracellular region  extracellular space  cytoplasm  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  B cell differentiation  megakaryocyte differentiation  positive regulation of peptidyl-serine phosphorylation  positive regulation of MAPK cascade  fat cell differentiation  positive regulation of transcription from RNA polymerase II promoter  negative regulation of hormone secretion  positive regulation of peptidyl-tyrosine phosphorylation  regulation of complement-dependent cytotoxicity  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTARegulation of hematopoiesis by cytokines [Genes]    Cytokines and Inflammatory Response [Genes]    Erythrocyte Differentiation Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Hematopoietic cell lineage    Rheumatoid arthritis   
NDEx NetworkIL11
Atlas of Cancer Signalling NetworkIL11
Wikipedia pathwaysIL11
Orthology - Evolution
OrthoDB3589
GeneTree (enSembl)ENSG00000095752
Phylogenetic Trees/Animal Genes : TreeFamIL11
HOVERGENP20809
HOGENOMP20809
Homologs : HomoloGeneIL11
Homology/Alignments : Family Browser (UCSC)IL11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL11
dbVarIL11
ClinVarIL11
1000_GenomesIL11 
Exome Variant ServerIL11
ExAC (Exome Aggregation Consortium)IL11 (select the gene name)
Genetic variants : HAPMAP3589
Genomic Variants (DGV)IL11 [DGVbeta]
DECIPHERIL11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL11 
Mutations
ICGC Data PortalIL11 
TCGA Data PortalIL11 
Broad Tumor PortalIL11
OASIS PortalIL11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL11
DgiDB (Drug Gene Interaction Database)IL11
DoCM (Curated mutations)IL11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL11 (select a term)
intoGenIL11
Cancer3DIL11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147681   
Orphanet
MedgenIL11
Genetic Testing Registry IL11
NextProtP20809 [Medical]
TSGene3589
GENETestsIL11
Target ValidationIL11
Huge Navigator IL11 [HugePedia]
snp3D : Map Gene to Disease3589
BioCentury BCIQIL11
ClinGenIL11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3589
Chemical/Pharm GKB GenePA29781
Clinical trialIL11
Miscellaneous
canSAR (ICR)IL11 (select the gene name)
Probes
Litterature
PubMed139 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL11
EVEXIL11
GoPubMedIL11
iHOPIL11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:13:04 CEST 2017

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