IL13RA2 (interleukin 13 receptor subunit alpha 2)

2007-02-01  

Identity

HGNC
LOCATION
Xq23
LOCUSID
ALIAS
CD213A2,CT19,IL-13R,IL13BP

Other Information

Locus ID:

NCBI: 3598
MIM: 300130
HGNC: 5975
Ensembl: ENSG00000123496

Variants:

dbSNP: 3598
ClinVar: 3598
TCGA: ENSG00000123496
COSMIC: IL13RA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123496ENST00000243213Q14627
ENSG00000123496ENST00000371936Q14627

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
163278022006IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.281
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
205431122010IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.68
225056472012High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis.51
178047062007Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: implications for targeted therapies.50
181722712008Interleukin-13 receptor alpha 2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy.49
198876092009A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis.49
218588112012IL-13 regulates cancer invasion and metastasis through IL-13Rα2 via ERK/AP-1 pathway in mouse model of human ovarian cancer.49
122315262002Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain.45
285500912017Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants.44

Citation

Dessen P

IL13RA2 (interleukin 13 receptor subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45978/il13ra2