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IL21 (interleukin 21)

Identity

Alias_symbol (synonym)Za11
IL-21
Other aliasCVID11
HGNC (Hugo) IL21
LocusID (NCBI) 59067
Atlas_Id 40954
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 122612628 and ends at 122621057 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;16)(q27;p11) IL21R/BCL6


External links

Nomenclature
HGNC (Hugo)IL21   6005
Cards
Entrez_Gene (NCBI)IL21  59067  interleukin 21
AliasesCVID11; IL-21; Za11
GeneCards (Weizmann)IL21
Ensembl hg19 (Hinxton)ENSG00000138684 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138684 [Gene_View]  chr4:122612628-122621057 [Contig_View]  IL21 [Vega]
ICGC DataPortalENSG00000138684
TCGA cBioPortalIL21
AceView (NCBI)IL21
Genatlas (Paris)IL21
WikiGenes59067
SOURCE (Princeton)IL21
Genetics Home Reference (NIH)IL21
Genomic and cartography
GoldenPath hg38 (UCSC)IL21  -     chr4:122612628-122621057 -  4q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL21  -     4q27   [Description]    (hg19-Feb_2009)
EnsemblIL21 - 4q27 [CytoView hg19]  IL21 - 4q27 [CytoView hg38]
Mapping of homologs : NCBIIL21 [Mapview hg19]  IL21 [Mapview hg38]
OMIM605384   615767   
Gene and transcription
Genbank (Entrez)AF254069 BC066258 BC066259 BC066260 BC066261
RefSeq transcript (Entrez)NM_001207006 NM_021803
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL21
Cluster EST : UnigeneHs.567559 [ NCBI ]
CGAP (NCI)Hs.567559
Alternative Splicing GalleryENSG00000138684
Gene ExpressionIL21 [ NCBI-GEO ]   IL21 [ EBI - ARRAY_EXPRESS ]   IL21 [ SEEK ]   IL21 [ MEM ]
Gene Expression Viewer (FireBrowse)IL21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)59067
GTEX Portal (Tissue expression)IL21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBE4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBE4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBE4
Splice isoforms : SwissVarQ9HBE4
PhosPhoSitePlusQ9HBE4
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-15/IL-21_fam    IL-21   
Domain families : Pfam (Sanger)IL15 (PF02372)   
Domain families : Pfam (NCBI)pfam02372   
Conserved Domain (NCBI)IL21
DMDM Disease mutations59067
Blocks (Seattle)IL21
PDB (SRS)2OQP    3TGX   
PDB (PDBSum)2OQP    3TGX   
PDB (IMB)2OQP    3TGX   
PDB (RSDB)2OQP    3TGX   
Structural Biology KnowledgeBase2OQP    3TGX   
SCOP (Structural Classification of Proteins)2OQP    3TGX   
CATH (Classification of proteins structures)2OQP    3TGX   
SuperfamilyQ9HBE4
Human Protein AtlasENSG00000138684
Peptide AtlasQ9HBE4
HPRD05650
IPIIPI00877605   IPI00029151   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBE4
IntAct (EBI)Q9HBE4
FunCoupENSG00000138684
BioGRIDIL21
STRING (EMBL)IL21
ZODIACIL21
Ontologies - Pathways
QuickGOQ9HBE4
Ontology : AmiGOpositive regulation of cytokine production  cytokine activity  cytokine receptor binding  interleukin-2 receptor binding  extracellular space  immune response  signal transduction  positive regulation of cell proliferation  positive regulation of B cell proliferation  positive regulation of interleukin-17 production  positive regulation of tissue remodeling  positive regulation of T cell proliferation  positive regulation of interferon-gamma biosynthetic process  positive regulation of natural killer cell mediated cytotoxicity  cell maturation  positive regulation of inflammatory response  
Ontology : EGO-EBIpositive regulation of cytokine production  cytokine activity  cytokine receptor binding  interleukin-2 receptor binding  extracellular space  immune response  signal transduction  positive regulation of cell proliferation  positive regulation of B cell proliferation  positive regulation of interleukin-17 production  positive regulation of tissue remodeling  positive regulation of T cell proliferation  positive regulation of interferon-gamma biosynthetic process  positive regulation of natural killer cell mediated cytotoxicity  cell maturation  positive regulation of inflammatory response  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Inflammatory bowel disease (IBD)   
NDEx NetworkIL21
Atlas of Cancer Signalling NetworkIL21
Wikipedia pathwaysIL21
Orthology - Evolution
OrthoDB59067
GeneTree (enSembl)ENSG00000138684
Phylogenetic Trees/Animal Genes : TreeFamIL21
HOVERGENQ9HBE4
HOGENOMQ9HBE4
Homologs : HomoloGeneIL21
Homology/Alignments : Family Browser (UCSC)IL21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL21
dbVarIL21
ClinVarIL21
1000_GenomesIL21 
Exome Variant ServerIL21
ExAC (Exome Aggregation Consortium)IL21 (select the gene name)
Genetic variants : HAPMAP59067
Genomic Variants (DGV)IL21 [DGVbeta]
DECIPHERIL21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL21 
Mutations
ICGC Data PortalIL21 
TCGA Data PortalIL21 
Broad Tumor PortalIL21
OASIS PortalIL21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL21
DgiDB (Drug Gene Interaction Database)IL21
DoCM (Curated mutations)IL21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL21 (select a term)
intoGenIL21
Cancer3DIL21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605384    615767   
Orphanet19277   
MedgenIL21
Genetic Testing Registry IL21
NextProtQ9HBE4 [Medical]
TSGene59067
GENETestsIL21
Target ValidationIL21
Huge Navigator IL21 [HugePedia]
snp3D : Map Gene to Disease59067
BioCentury BCIQIL21
ClinGenIL21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD59067
Chemical/Pharm GKB GenePA29820
Clinical trialIL21
Miscellaneous
canSAR (ICR)IL21 (select the gene name)
Probes
Litterature
PubMed306 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL21
EVEXIL21
GoPubMedIL21
iHOPIL21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:23 CEST 2017

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