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ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains)

Identity

Alias_namesC6orf106
chromosome 6 open reading frame 106
Alias_symbol (synonym)FLJ22195
dJ391O22.4
Other aliasFP852
HGNC (Hugo) ILRUN
LocusID (NCBI) 64771
Atlas_Id 54178
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 34587280 and ends at 34696850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C6orf106 6p21.31 / LRRC1 6p12.1SPDEF 6p21.31 / C6orf106 6p21.31
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]

Solid Tumors TT_t0606p12p21ID107032 TT_t0606p21p21ID107096


External links

Nomenclature
HGNC (Hugo)ILRUN   21215
Cards
Entrez_Gene (NCBI)ILRUN  64771  inflammation and lipid regulator with UBA-like and NBR1-like domains
AliasesC6orf106; FP852; dJ391O22.4
GeneCards (Weizmann)ILRUN
Ensembl hg19 (Hinxton)ENSG00000196821 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196821 [Gene_View]  ENSG00000196821 [Sequence]  chr6:34587280-34696850 [Contig_View]  ILRUN [Vega]
ICGC DataPortalENSG00000196821
TCGA cBioPortalILRUN
AceView (NCBI)ILRUN
Genatlas (Paris)ILRUN
WikiGenes64771
SOURCE (Princeton)ILRUN
Genetics Home Reference (NIH)ILRUN
Genomic and cartography
GoldenPath hg38 (UCSC)ILRUN  -     chr6:34587280-34696850 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ILRUN  -     -   [Description]    (hg19-Feb_2009)
GoldenPathILRUN - - [CytoView hg19]  ILRUN - - [CytoView hg38]
ImmunoBaseENSG00000196821
Mapping of homologs : NCBIILRUN [Mapview hg19]  ILRUN [Mapview hg38]
OMIM612217   
Gene and transcription
Genbank (Entrez)AF052106 AF370387 AI469525 AK025848 AK056964
RefSeq transcript (Entrez)NM_022758 NM_024294
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ILRUN
Cluster EST : UnigeneHs.716193 [ NCBI ]
CGAP (NCI)Hs.716193
Alternative Splicing GalleryENSG00000196821
Gene ExpressionILRUN [ NCBI-GEO ]   ILRUN [ EBI - ARRAY_EXPRESS ]   ILRUN [ SEEK ]   ILRUN [ MEM ]
Gene Expression Viewer (FireBrowse)ILRUN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64771
GTEX Portal (Tissue expression)ILRUN
Human Protein AtlasENSG00000196821-ILRUN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6K1
Splice isoforms : SwissVarQ9H6K1
PhosPhoSitePlusQ9H6K1
Domains : Interpro (EBI)Ig-like_fold    N_BRCA1_central    UBA-like_sf   
Domain families : Pfam (Sanger)N_BRCA1_IG (PF16158)   
Domain families : Pfam (NCBI)pfam16158   
Conserved Domain (NCBI)ILRUN
DMDM Disease mutations64771
Blocks (Seattle)ILRUN
SuperfamilyQ9H6K1
Human Protein Atlas [tissue]ENSG00000196821-ILRUN [tissue]
Peptide AtlasQ9H6K1
HPRD12837
IPIIPI00013269   IPI00332642   IPI00435958   IPI00921603   IPI00642125   
Protein Interaction databases
DIP (DOE-UCLA)Q9H6K1
IntAct (EBI)Q9H6K1
FunCoupENSG00000196821
BioGRIDILRUN
STRING (EMBL)ILRUN
ZODIACILRUN
Ontologies - Pathways
QuickGOQ9H6K1
Ontology : AmiGOphagophore assembly site  protein binding  nucleus  cytoplasm  autophagosome  macroautophagy  negative regulation of type I interferon production  negative regulation of tumor necrosis factor production  ubiquitin binding  negative regulation of DNA binding  innate immune response  negative regulation of defense response to virus  negative regulation of protein localization to nucleus  
Ontology : EGO-EBIphagophore assembly site  protein binding  nucleus  cytoplasm  autophagosome  macroautophagy  negative regulation of type I interferon production  negative regulation of tumor necrosis factor production  ubiquitin binding  negative regulation of DNA binding  innate immune response  negative regulation of defense response to virus  negative regulation of protein localization to nucleus  
NDEx NetworkILRUN
Atlas of Cancer Signalling NetworkILRUN
Wikipedia pathwaysILRUN
Orthology - Evolution
OrthoDB64771
GeneTree (enSembl)ENSG00000196821
Phylogenetic Trees/Animal Genes : TreeFamILRUN
HOGENOMQ9H6K1
Homologs : HomoloGeneILRUN
Homology/Alignments : Family Browser (UCSC)ILRUN
Gene fusions - Rearrangements
Fusion : MitelmanC6orf106/LRRC1 [6p21.31/6p12.1]  
Fusion : MitelmanC6orf106/SPDEF [6p21.31/6p21.31]  [t(6;6)(p21;p21)]  
Fusion : MitelmanSPDEF/C6orf106 [6p21.31/6p21.31]  [t(6;6)(p21;p21)]  
Fusion PortalC6orf106 6p21.31 LRRC1 6p12.1 KIRC
Fusion PortalSPDEF 6p21.31 C6orf106 6p21.31 BRCA
Fusion : QuiverILRUN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerILRUN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ILRUN
dbVarILRUN
ClinVarILRUN
1000_GenomesILRUN 
Exome Variant ServerILRUN
ExAC (Exome Aggregation Consortium)ENSG00000196821
GNOMAD BrowserENSG00000196821
Varsome BrowserILRUN
Genetic variants : HAPMAP64771
Genomic Variants (DGV)ILRUN [DGVbeta]
DECIPHERILRUN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisILRUN 
Mutations
ICGC Data PortalILRUN 
TCGA Data PortalILRUN 
Broad Tumor PortalILRUN
OASIS PortalILRUN [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDILRUN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ILRUN
DgiDB (Drug Gene Interaction Database)ILRUN
DoCM (Curated mutations)ILRUN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ILRUN (select a term)
intoGenILRUN
Cancer3DILRUN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612217   
Orphanet
DisGeNETILRUN
MedgenILRUN
Genetic Testing Registry ILRUN
NextProtQ9H6K1 [Medical]
TSGene64771
GENETestsILRUN
Target ValidationILRUN
Huge Navigator ILRUN [HugePedia]
snp3D : Map Gene to Disease64771
BioCentury BCIQILRUN
ClinGenILRUN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64771
Chemical/Pharm GKB GenePA134935866
Clinical trialILRUN
Miscellaneous
canSAR (ICR)ILRUN (select the gene name)
DataMed IndexILRUN
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineILRUN
EVEXILRUN
GoPubMedILRUN
iHOPILRUN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 26 18:12:43 CEST 2019

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