Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

IMPDH2 (inosine monophosphate dehydrogenase 2)

Identity

Alias (NCBI)IMPD2
IMPDH-II
HGNC (Hugo) IMPDH2
HGNC Previous nameIMP (inosine 5'-monophosphate) dehydrogenase 2
LocusID (NCBI) 3615
Atlas_Id 40972
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49024329 and ends at 49029398 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IMPDH2 (3p21.31) / IMPDH2 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)IMPDH2   6053
Cards
Entrez_Gene (NCBI)IMPDH2    inosine monophosphate dehydrogenase 2
AliasesIMPD2; IMPDH-II
GeneCards (Weizmann)IMPDH2
Ensembl hg19 (Hinxton)ENSG00000178035 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178035 [Gene_View]  ENSG00000178035 [Sequence]  chr3:49024329-49029398 [Contig_View]  IMPDH2 [Vega]
ICGC DataPortalENSG00000178035
TCGA cBioPortalIMPDH2
AceView (NCBI)IMPDH2
Genatlas (Paris)IMPDH2
SOURCE (Princeton)IMPDH2
Genetics Home Reference (NIH)IMPDH2
Genomic and cartography
GoldenPath hg38 (UCSC)IMPDH2  -     chr3:49024329-49029398 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IMPDH2  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathIMPDH2 - 3p21.31 [CytoView hg19]  IMPDH2 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000178035
genome Data Viewer NCBIIMPDH2 [Mapview hg19]  
OMIM146691   617995   
Gene and transcription
Genbank (Entrez)AK293397 AY545560 BC006124 BC009236 BC012840
RefSeq transcript (Entrez)NM_000884
Consensus coding sequences : CCDS (NCBI)IMPDH2
Alternative Splicing GalleryENSG00000178035
Gene ExpressionIMPDH2 [ NCBI-GEO ]   IMPDH2 [ EBI - ARRAY_EXPRESS ]   IMPDH2 [ SEEK ]   IMPDH2 [ MEM ]
Gene Expression Viewer (FireBrowse)IMPDH2 [ Firebrowse - Broad ]
GenevisibleExpression of IMPDH2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3615
GTEX Portal (Tissue expression)IMPDH2
Human Protein AtlasENSG00000178035-IMPDH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12268
PhosPhoSitePlusP12268
Domaine pattern : Prosite (Expaxy)CBS (PS51371)    IMP_DH_GMP_RED (PS00487)   
Domains : Interpro (EBI)Aldolase_TIM    CBS_dom    IMP_DH    IMP_DH/GMP_Rdtase_CS    IMP_DH_GMPRt   
Domain families : Pfam (Sanger)CBS (PF00571)    IMPDH (PF00478)   
Domain families : Pfam (NCBI)pfam00571    pfam00478   
Domain families : Smart (EMBL)CBS (SM00116)  
Conserved Domain (NCBI)IMPDH2
PDB (RSDB)1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
PDB Europe1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
PDB (PDBSum)1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
PDB (IMB)1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
Structural Biology KnowledgeBase1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
SCOP (Structural Classification of Proteins)1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
CATH (Classification of proteins structures)1B3O    1NF7    1NFB    6I0M    6I0O    6U8E    6U8N    6U8R    6U8S    6U9O    6UA2    6UA4    6UA5    6UAJ    6UC2    6UDO    6UDP    6UDQ   
SuperfamilyP12268
AlphaFold pdb e-kbP12268   
Human Protein Atlas [tissue]ENSG00000178035-IMPDH2 [tissue]
HPRD00895
Protein Interaction databases
DIP (DOE-UCLA)P12268
IntAct (EBI)P12268
BioGRIDIMPDH2
STRING (EMBL)IMPDH2
ZODIACIMPDH2
Ontologies - Pathways
QuickGOP12268
Ontology : AmiGOnucleotide binding  DNA binding  RNA binding  IMP dehydrogenase activity  IMP dehydrogenase activity  protein binding  extracellular region  nucleus  cytoplasm  cytoplasm  peroxisomal membrane  cytosol  cytosol  GMP biosynthetic process  GTP biosynthetic process  GTP biosynthetic process  circadian rhythm  purine ribonucleoside monophosphate biosynthetic process  membrane  secretory granule lumen  identical protein binding  neutrophil degranulation  lymphocyte proliferation  metal ion binding  retina development in camera-type eye  extracellular exosome  cellular response to interleukin-4  ficolin-1-rich granule lumen  
Ontology : EGO-EBInucleotide binding  DNA binding  RNA binding  IMP dehydrogenase activity  IMP dehydrogenase activity  protein binding  extracellular region  nucleus  cytoplasm  cytoplasm  peroxisomal membrane  cytosol  cytosol  GMP biosynthetic process  GTP biosynthetic process  GTP biosynthetic process  circadian rhythm  purine ribonucleoside monophosphate biosynthetic process  membrane  secretory granule lumen  identical protein binding  neutrophil degranulation  lymphocyte proliferation  metal ion binding  retina development in camera-type eye  extracellular exosome  cellular response to interleukin-4  ficolin-1-rich granule lumen  
Pathways : KEGGPurine metabolism    Drug metabolism - other enzymes   
NDEx NetworkIMPDH2
Atlas of Cancer Signalling NetworkIMPDH2
Wikipedia pathwaysIMPDH2
Orthology - Evolution
OrthoDB3615
GeneTree (enSembl)ENSG00000178035
Phylogenetic Trees/Animal Genes : TreeFamIMPDH2
Homologs : HomoloGeneIMPDH2
Homology/Alignments : Family Browser (UCSC)IMPDH2
Gene fusions - Rearrangements
Fusion : QuiverIMPDH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIMPDH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IMPDH2
dbVarIMPDH2
ClinVarIMPDH2
MonarchIMPDH2
1000_GenomesIMPDH2 
Exome Variant ServerIMPDH2
GNOMAD BrowserENSG00000178035
Varsome BrowserIMPDH2
Genomic Variants (DGV)IMPDH2 [DGVbeta]
DECIPHERIMPDH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIMPDH2 
Mutations
ICGC Data PortalIMPDH2 
TCGA Data PortalIMPDH2 
Broad Tumor PortalIMPDH2
OASIS PortalIMPDH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIMPDH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIMPDH2
Mutations and Diseases : HGMDIMPDH2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch IMPDH2
DgiDB (Drug Gene Interaction Database)IMPDH2
DoCM (Curated mutations)IMPDH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IMPDH2 (select a term)
Cancer3DIMPDH2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146691    617995   
Orphanet
DisGeNETIMPDH2
MedgenIMPDH2
Genetic Testing Registry IMPDH2
NextProtP12268 [Medical]
GENETestsIMPDH2
Target ValidationIMPDH2
Huge Navigator IMPDH2 [HugePedia]
ClinGenIMPDH2
Clinical trials, drugs, therapy
MyCancerGenomeIMPDH2
Protein Interactions : CTDIMPDH2
Pharm GKB GenePA29863
Pharm GKB PathwaysPA165964832   
PharosP12268
Clinical trialIMPDH2
Miscellaneous
canSAR (ICR)IMPDH2
HarmonizomeIMPDH2
DataMed IndexIMPDH2
Probes
Litterature
PubMed165 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIMPDH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:18:45 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.