IMPDH2 (inosine monophosphate dehydrogenase 2)

2003-08-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
IMPD2,IMPDH-II
FUSION GENES

Other Information

Locus ID:

NCBI: 3615
MIM: 146691
HGNC: 6053
Ensembl: ENSG00000178035

Variants:

dbSNP: 3615
ClinVar: 3615
TCGA: ENSG00000178035
COSMIC: IMPDH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178035ENST00000326739P12268
ENSG00000178035ENST00000326739A0A384N6C2
ENSG00000178035ENST00000429182H0Y4R1
ENSG00000178035ENST00000442157E7ETK5

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Drug metabolism - other enzymesKEGGko00983
Purine metabolismKEGGhsa00230
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine ribonucleoside monophosphate biosynthesisREACTOMER-HSA-73817
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalClinicalAnnotation, PathwayassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765, 24220207
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 21996196, 22960765
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765

References

Pubmed IDYearTitleCitations
186771082008Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.88
176608022007Prognostic significance of drug-regulated genes in high-grade osteosarcoma.44
244774772014Glutamine deprivation initiates reversible assembly of mammalian rods and rings.27
184449452008Association of four DNA polymorphisms with acute rejection after kidney transplantation.21
196178642009Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism.19
196178642009Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism.19
208089342010Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells.16
174967272007A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.13
174967272007A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.13
193675812010Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.13

Citation

Dessen P

IMPDH2 (inosine monophosphate dehydrogenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40972/impdh2