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IMPDH2 (inosine monophosphate dehydrogenase 2)

Identity

Alias_namesIMP (inosine 5'-monophosphate) dehydrogenase 2
Other aliasIMPD2
IMPDH-II
HGNC (Hugo) IMPDH2
LocusID (NCBI) 3615
Atlas_Id 40972
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49024329 and ends at 49029442 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IMPDH2 (3p21.31) / IMPDH2 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IMPDH2   6053
Cards
Entrez_Gene (NCBI)IMPDH2  3615  inosine monophosphate dehydrogenase 2
AliasesIMPD2; IMPDH-II
GeneCards (Weizmann)IMPDH2
Ensembl hg19 (Hinxton)ENSG00000178035 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178035 [Gene_View]  chr3:49024329-49029442 [Contig_View]  IMPDH2 [Vega]
ICGC DataPortalENSG00000178035
TCGA cBioPortalIMPDH2
AceView (NCBI)IMPDH2
Genatlas (Paris)IMPDH2
WikiGenes3615
SOURCE (Princeton)IMPDH2
Genetics Home Reference (NIH)IMPDH2
Genomic and cartography
GoldenPath hg38 (UCSC)IMPDH2  -     chr3:49024329-49029442 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IMPDH2  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblIMPDH2 - 3p21.31 [CytoView hg19]  IMPDH2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIIMPDH2 [Mapview hg19]  IMPDH2 [Mapview hg38]
OMIM146691   
Gene and transcription
Genbank (Entrez)AK293397 AY545560 BC006124 BC009236 BC012840
RefSeq transcript (Entrez)NM_000884
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IMPDH2
Cluster EST : UnigeneHs.654400 [ NCBI ]
CGAP (NCI)Hs.654400
Alternative Splicing GalleryENSG00000178035
Gene ExpressionIMPDH2 [ NCBI-GEO ]   IMPDH2 [ EBI - ARRAY_EXPRESS ]   IMPDH2 [ SEEK ]   IMPDH2 [ MEM ]
Gene Expression Viewer (FireBrowse)IMPDH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3615
GTEX Portal (Tissue expression)IMPDH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP12268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP12268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP12268
Splice isoforms : SwissVarP12268
PhosPhoSitePlusP12268
Domaine pattern : Prosite (Expaxy)CBS (PS51371)    IMP_DH_GMP_RED (PS00487)   
Domains : Interpro (EBI)Aldolase_TIM    CBS_dom    IMP_DH    IMP_DH/GMP_Rdtase_CS    IMP_DH_GMPRt   
Domain families : Pfam (Sanger)CBS (PF00571)    IMPDH (PF00478)   
Domain families : Pfam (NCBI)pfam00571    pfam00478   
Domain families : Smart (EMBL)CBS (SM00116)  
Conserved Domain (NCBI)IMPDH2
DMDM Disease mutations3615
Blocks (Seattle)IMPDH2
PDB (SRS)1B3O    1NF7    1NFB   
PDB (PDBSum)1B3O    1NF7    1NFB   
PDB (IMB)1B3O    1NF7    1NFB   
PDB (RSDB)1B3O    1NF7    1NFB   
Structural Biology KnowledgeBase1B3O    1NF7    1NFB   
SCOP (Structural Classification of Proteins)1B3O    1NF7    1NFB   
CATH (Classification of proteins structures)1B3O    1NF7    1NFB   
SuperfamilyP12268
Human Protein AtlasENSG00000178035
Peptide AtlasP12268
HPRD00895
IPIIPI00291510   IPI00925196   IPI00924999   
Protein Interaction databases
DIP (DOE-UCLA)P12268
IntAct (EBI)P12268
FunCoupENSG00000178035
BioGRIDIMPDH2
STRING (EMBL)IMPDH2
ZODIACIMPDH2
Ontologies - Pathways
QuickGOP12268
Ontology : AmiGOnucleotide binding  DNA binding  RNA binding  IMP dehydrogenase activity  IMP dehydrogenase activity  protein binding  extracellular region  nucleus  cytoplasm  peroxisomal membrane  cytosol  cytosol  GMP biosynthetic process  GTP biosynthetic process  purine ribonucleoside monophosphate biosynthetic process  membrane  secretory granule lumen  neutrophil degranulation  lymphocyte proliferation  metal ion binding  protein homotetramerization  oxidation-reduction process  retina development in camera-type eye  extracellular exosome  cellular response to interleukin-4  ficolin-1-rich granule lumen  
Ontology : EGO-EBInucleotide binding  DNA binding  RNA binding  IMP dehydrogenase activity  IMP dehydrogenase activity  protein binding  extracellular region  nucleus  cytoplasm  peroxisomal membrane  cytosol  cytosol  GMP biosynthetic process  GTP biosynthetic process  purine ribonucleoside monophosphate biosynthetic process  membrane  secretory granule lumen  neutrophil degranulation  lymphocyte proliferation  metal ion binding  protein homotetramerization  oxidation-reduction process  retina development in camera-type eye  extracellular exosome  cellular response to interleukin-4  ficolin-1-rich granule lumen  
Pathways : KEGGPurine metabolism    Drug metabolism - other enzymes   
NDEx NetworkIMPDH2
Atlas of Cancer Signalling NetworkIMPDH2
Wikipedia pathwaysIMPDH2
Orthology - Evolution
OrthoDB3615
GeneTree (enSembl)ENSG00000178035
Phylogenetic Trees/Animal Genes : TreeFamIMPDH2
HOVERGENP12268
HOGENOMP12268
Homologs : HomoloGeneIMPDH2
Homology/Alignments : Family Browser (UCSC)IMPDH2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIMPDH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IMPDH2
dbVarIMPDH2
ClinVarIMPDH2
1000_GenomesIMPDH2 
Exome Variant ServerIMPDH2
ExAC (Exome Aggregation Consortium)IMPDH2 (select the gene name)
Genetic variants : HAPMAP3615
Genomic Variants (DGV)IMPDH2 [DGVbeta]
DECIPHERIMPDH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIMPDH2 
Mutations
ICGC Data PortalIMPDH2 
TCGA Data PortalIMPDH2 
Broad Tumor PortalIMPDH2
OASIS PortalIMPDH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIMPDH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIMPDH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IMPDH2
DgiDB (Drug Gene Interaction Database)IMPDH2
DoCM (Curated mutations)IMPDH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IMPDH2 (select a term)
intoGenIMPDH2
Cancer3DIMPDH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146691   
Orphanet
MedgenIMPDH2
Genetic Testing Registry IMPDH2
NextProtP12268 [Medical]
TSGene3615
GENETestsIMPDH2
Target ValidationIMPDH2
Huge Navigator IMPDH2 [HugePedia]
snp3D : Map Gene to Disease3615
BioCentury BCIQIMPDH2
ClinGenIMPDH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3615
Chemical/Pharm GKB GenePA29863
Clinical trialIMPDH2
Miscellaneous
canSAR (ICR)IMPDH2 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIMPDH2
EVEXIMPDH2
GoPubMedIMPDH2
iHOPIMPDH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:38:31 CEST 2017

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