Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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INPP5J (inositol polyphosphate-5-phosphatase J)

Identity

Other namesINPP5
PIB5PA
PIPP
HGNC (Hugo) INPP5J
LocusID (NCBI) 27124
Location 22q12.2
Location_base_pair Starts at 31518909 and ends at 31530683 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)INPP5J   8956
Cards
Entrez_Gene (NCBI)INPP5J  27124  inositol polyphosphate-5-phosphatase J
GeneCards (Weizmann)INPP5J
Ensembl hg19 (Hinxton)ENSG00000185133 [Gene_View]  chr22:31518909-31530683 [Contig_View]  INPP5J [Vega]
Ensembl hg38 (Hinxton)ENSG00000185133 [Gene_View]  chr22:31518909-31530683 [Contig_View]  INPP5J [Vega]
ICGC DataPortalENSG00000185133
cBioPortalINPP5J
AceView (NCBI)INPP5J
Genatlas (Paris)INPP5J
WikiGenes27124
SOURCE (Princeton)INPP5J
Genomic and cartography
GoldenPath hg19 (UCSC)INPP5J  -     chr22:31518909-31530683 +  22q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)INPP5J  -     22q12.2   [Description]    (hg38-Dec_2013)
EnsemblINPP5J - 22q12.2 [CytoView hg19]  INPP5J - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBIINPP5J [Mapview hg19]  INPP5J [Mapview hg38]
OMIM606481   
Gene and transcription
Genbank (Entrez)AK092859 AK095944 AK126610 AK293992 AK308921
RefSeq transcript (Entrez)NM_001002837 NM_001284285 NM_001284286 NM_001284287 NM_001284288 NM_001284289 NM_014422
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)INPP5J
Cluster EST : UnigeneHs.517549 [ NCBI ]
CGAP (NCI)Hs.517549
Alternative Splicing : Fast-db (Paris)GSHG0019955
Alternative Splicing GalleryENSG00000185133
Gene ExpressionINPP5J [ NCBI-GEO ]     INPP5J [ SEEK ]   INPP5J [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15735 (Uniprot)
NextProtQ15735  [Medical]
With graphics : InterProQ15735
Splice isoforms : SwissVarQ15735 (Swissvar)
Catalytic activity : Enzyme3.1.3.56 [ Enzyme-Expasy ]   3.1.3.563.1.3.56 [ IntEnz-EBI ]   3.1.3.56 [ BRENDA ]   3.1.3.56 [ KEGG ]   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    IPPc   
Related proteins : CluSTrQ15735
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Domain families : Smart (EMBL)IPPc (SM00128)  
DMDM Disease mutations27124
Blocks (Seattle)Q15735
Human Protein AtlasENSG00000185133
Peptide AtlasQ15735
HPRD07573
IPIIPI00242711   IPI00242712   IPI00445092   IPI00894005   IPI00894224   IPI00893848   IPI00893616   
Protein Interaction databases
DIP (DOE-UCLA)Q15735
IntAct (EBI)Q15735
FunCoupENSG00000185133
BioGRIDINPP5J
IntegromeDBINPP5J
STRING (EMBL)INPP5J
Ontologies - Pathways
QuickGOQ15735
Ontology : AmiGOruffle  inositol-polyphosphate 5-phosphatase activity  protein binding  cytoplasm  cytosol  plasma membrane  phospholipid metabolic process  phosphatidylinositol biosynthetic process  negative regulation of neuron projection development  SH3 domain binding  growth cone  negative regulation of microtubule polymerization  negative regulation of peptidyl-serine phosphorylation  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  dendritic shaft  inositol phosphate metabolic process  small molecule metabolic process  phosphatidylinositol dephosphorylation  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  
Ontology : EGO-EBIruffle  inositol-polyphosphate 5-phosphatase activity  protein binding  cytoplasm  cytosol  plasma membrane  phospholipid metabolic process  phosphatidylinositol biosynthetic process  negative regulation of neuron projection development  SH3 domain binding  growth cone  negative regulation of microtubule polymerization  negative regulation of peptidyl-serine phosphorylation  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  dendritic shaft  inositol phosphate metabolic process  small molecule metabolic process  phosphatidylinositol dephosphorylation  inositol-1,4,5-trisphosphate 5-phosphatase activity  inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity  
Pathways : KEGGInositol phosphate metabolism    Phosphatidylinositol signaling system   
Protein Interaction DatabaseINPP5J
DoCM (Curated mutations)INPP5J
Wikipedia pathwaysINPP5J
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerINPP5J [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)INPP5J
dbVarINPP5J
ClinVarINPP5J
1000_GenomesINPP5J 
Exome Variant ServerINPP5J
SNP (GeneSNP Utah)INPP5J
SNP : HGBaseINPP5J
Genetic variants : HAPMAPINPP5J
Genomic Variants (DGV)INPP5J [DGVbeta]
Mutations
ICGC Data PortalENSG00000185133 
Somatic Mutations in Cancer : COSMICINPP5J 
CONAN: Copy Number AnalysisINPP5J 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:31518909-31530683
Mutations and Diseases : HGMDINPP5J
OMIM606481   
MedgenINPP5J
NextProtQ15735 [Medical]
GENETestsINPP5J
Disease Genetic AssociationINPP5J
Huge Navigator INPP5J [HugePedia]  INPP5J [HugeCancerGEM]
snp3D : Map Gene to Disease27124
DGIdb (Drug Gene Interaction db)INPP5J
General knowledge
Homologs : HomoloGeneINPP5J
Homology/Alignments : Family Browser (UCSC)INPP5J
Phylogenetic Trees/Animal Genes : TreeFamINPP5J
Chemical/Protein Interactions : CTD27124
Chemical/Pharm GKB GenePA164720918
Clinical trialINPP5J
Cancer Resource (Charite)ENSG00000185133
Other databases
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
CoreMineINPP5J
GoPubMedINPP5J
iHOPINPP5J
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:42:14 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.