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IQGAP2 (IQ motif containing GTPase activating protein 2)

Identity

Other alias-
HGNC (Hugo) IQGAP2
LocusID (NCBI) 10788
Atlas_Id 40988
Location 5q13.3  [Link to chromosome band 5q13]
Location_base_pair Starts at 75843234 and ends at 76003957 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAV1 (7q31.2) / IQGAP2 (5q13.3)IQGAP2 (5q13.3) / ACOT12 (5q14.1)IQGAP2 (5q13.3) / ATRNL1 (10q25.3)
IQGAP2 (5q13.3) / C15orf57 (15q15.1)IQGAP2 (5q13.3) / PDGFB (22q13.1)PWWP2A (5q33.3) / IQGAP2 (5q13.3)
RPL10 (Xq28) / IQGAP2 (5q13.3)IQGAP2 5q13.3 / ACOT12 5q14.1IQGAP2 5q13.3 / ATRNL1 10q25.3
PWWP2A 5q33.3 / IQGAP2 5q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IQGAP2   6111
Cards
Entrez_Gene (NCBI)IQGAP2  10788  IQ motif containing GTPase activating protein 2
Aliases
GeneCards (Weizmann)IQGAP2
Ensembl hg19 (Hinxton)ENSG00000145703 [Gene_View]  chr5:75843234-76003957 [Contig_View]  IQGAP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000145703 [Gene_View]  chr5:75843234-76003957 [Contig_View]  IQGAP2 [Vega]
ICGC DataPortalENSG00000145703
TCGA cBioPortalIQGAP2
AceView (NCBI)IQGAP2
Genatlas (Paris)IQGAP2
WikiGenes10788
SOURCE (Princeton)IQGAP2
Genetics Home Reference (NIH)IQGAP2
Genomic and cartography
GoldenPath hg19 (UCSC)IQGAP2  -     chr5:75843234-76003957 +  5q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IQGAP2  -     5q13.3   [Description]    (hg38-Dec_2013)
EnsemblIQGAP2 - 5q13.3 [CytoView hg19]  IQGAP2 - 5q13.3 [CytoView hg38]
Mapping of homologs : NCBIIQGAP2 [Mapview hg19]  IQGAP2 [Mapview hg38]
OMIM605401   
Gene and transcription
Genbank (Entrez)AB208856 AK291066 AK302510 AK302599 AK302981
RefSeq transcript (Entrez)NM_001285460 NM_001285461 NM_001285462 NM_006633
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)IQGAP2
Cluster EST : UnigeneHs.291030 [ NCBI ]
CGAP (NCI)Hs.291030
Alternative Splicing GalleryENSG00000145703
Gene ExpressionIQGAP2 [ NCBI-GEO ]   IQGAP2 [ EBI - ARRAY_EXPRESS ]   IQGAP2 [ SEEK ]   IQGAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)IQGAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10788
GTEX Portal (Tissue expression)IQGAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13576   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13576  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13576
Splice isoforms : SwissVarQ13576
PhosPhoSitePlusQ13576
Domaine pattern : Prosite (Expaxy)CH (PS50021)    IQ (PS50096)    RAS_GTPASE_ACTIV_1 (PS00509)    RAS_GTPASE_ACTIV_2 (PS50018)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)CH-domain    IQ_motif_EF-hand-BS    RasGAP_C    RasGAP_CS    RasGAP_dom    Rho_GTPase_activation_prot    WW_dom   
Domain families : Pfam (Sanger)CH (PF00307)    IQ (PF00612)    RasGAP (PF00616)    RasGAP_C (PF03836)   
Domain families : Pfam (NCBI)pfam00307    pfam00612    pfam00616    pfam03836   
Domain families : Smart (EMBL)CH (SM00033)  IQ (SM00015)  RasGAP (SM00323)  
Conserved Domain (NCBI)IQGAP2
DMDM Disease mutations10788
Blocks (Seattle)IQGAP2
PDB (SRS)3IEZ    4EZA   
PDB (PDBSum)3IEZ    4EZA   
PDB (IMB)3IEZ    4EZA   
PDB (RSDB)3IEZ    4EZA   
Structural Biology KnowledgeBase3IEZ    4EZA   
SCOP (Structural Classification of Proteins)3IEZ    4EZA   
CATH (Classification of proteins structures)3IEZ    4EZA   
SuperfamilyQ13576
Human Protein AtlasENSG00000145703
Peptide AtlasQ13576
HPRD09253
IPIIPI00299048   IPI00871809   IPI00965153   IPI00968174   IPI00967610   IPI00965765   IPI00964564   IPI00964844   IPI00967264   IPI00963944   
Protein Interaction databases
DIP (DOE-UCLA)Q13576
IntAct (EBI)Q13576
FunCoupENSG00000145703
BioGRIDIQGAP2
STRING (EMBL)IQGAP2
ZODIACIQGAP2
Ontologies - Pathways
QuickGOQ13576
Ontology : AmiGOactin binding  GTPase inhibitor activity  GTPase activator activity  calmodulin binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytoplasm  cytosol  microtubule  microvillus  signal transduction  small GTPase mediated signal transduction  cell surface  actin cytoskeleton  Rho GTPase binding  lamellipodium  filopodium  filamentous actin  negative regulation of GTPase activity  Arp2/3 complex-mediated actin nucleation  positive regulation of GTPase activity  Rac GTPase binding  actin filament binding  extracellular exosome  thrombin receptor signaling pathway  Arp2/3 complex binding  
Ontology : EGO-EBIactin binding  GTPase inhibitor activity  GTPase activator activity  calmodulin binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytoplasm  cytosol  microtubule  microvillus  signal transduction  small GTPase mediated signal transduction  cell surface  actin cytoskeleton  Rho GTPase binding  lamellipodium  filopodium  filamentous actin  negative regulation of GTPase activity  Arp2/3 complex-mediated actin nucleation  positive regulation of GTPase activity  Rac GTPase binding  actin filament binding  extracellular exosome  thrombin receptor signaling pathway  Arp2/3 complex binding  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkIQGAP2
Atlas of Cancer Signalling NetworkIQGAP2
Wikipedia pathwaysIQGAP2
Orthology - Evolution
OrthoDB10788
GeneTree (enSembl)ENSG00000145703
Phylogenetic Trees/Animal Genes : TreeFamIQGAP2
HOVERGENQ13576
HOGENOMQ13576
Homologs : HomoloGeneIQGAP2
Homology/Alignments : Family Browser (UCSC)IQGAP2
Gene fusions - Rearrangements
Fusion : MitelmanIQGAP2/ACOT12 [5q13.3/5q14.1]  
Fusion : MitelmanIQGAP2/ATRNL1 [5q13.3/10q25.3]  [t(5;10)(q13;q25)]  
Fusion : MitelmanPWWP2A/IQGAP2 [5q33.3/5q13.3]  [t(5;5)(q13;q33)]  
Fusion: TCGAIQGAP2 5q13.3 ACOT12 5q14.1 BRCA
Fusion: TCGAIQGAP2 5q13.3 ATRNL1 10q25.3 HNSC
Fusion: TCGAPWWP2A 5q33.3 IQGAP2 5q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIQGAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IQGAP2
dbVarIQGAP2
ClinVarIQGAP2
1000_GenomesIQGAP2 
Exome Variant ServerIQGAP2
ExAC (Exome Aggregation Consortium)IQGAP2 (select the gene name)
Genetic variants : HAPMAP10788
Genomic Variants (DGV)IQGAP2 [DGVbeta]
DECIPHER (Syndromes)5:75843234-76003957  ENSG00000145703
CONAN: Copy Number AnalysisIQGAP2 
Mutations
ICGC Data PortalIQGAP2 
TCGA Data PortalIQGAP2 
Broad Tumor PortalIQGAP2
OASIS PortalIQGAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIQGAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIQGAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IQGAP2
DgiDB (Drug Gene Interaction Database)IQGAP2
DoCM (Curated mutations)IQGAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IQGAP2 (select a term)
intoGenIQGAP2
Cancer3DIQGAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605401   
Orphanet
MedgenIQGAP2
Genetic Testing Registry IQGAP2
NextProtQ13576 [Medical]
TSGene10788
GENETestsIQGAP2
Huge Navigator IQGAP2 [HugePedia]
snp3D : Map Gene to Disease10788
BioCentury BCIQIQGAP2
ClinGenIQGAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10788
Chemical/Pharm GKB GenePA29911
Clinical trialIQGAP2
Miscellaneous
canSAR (ICR)IQGAP2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIQGAP2
EVEXIQGAP2
GoPubMedIQGAP2
iHOPIQGAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:11:01 CET 2017

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