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IRAK2 (interleukin 1 receptor associated kinase 2)

Identity

Other aliasIRAK-2
HGNC (Hugo) IRAK2
LocusID (NCBI) 3656
Atlas_Id 43327
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 10164879 and ends at 10243743 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IRAK2 (3p25.3) / SRGAP3 (3p25.3)IRAK2 3p25.3 / SRGAP3 3p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRAK2   6113
Cards
Entrez_Gene (NCBI)IRAK2  3656  interleukin 1 receptor associated kinase 2
AliasesIRAK-2
GeneCards (Weizmann)IRAK2
Ensembl hg19 (Hinxton)ENSG00000134070 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134070 [Gene_View]  chr3:10164879-10243743 [Contig_View]  IRAK2 [Vega]
ICGC DataPortalENSG00000134070
TCGA cBioPortalIRAK2
AceView (NCBI)IRAK2
Genatlas (Paris)IRAK2
WikiGenes3656
SOURCE (Princeton)IRAK2
Genetics Home Reference (NIH)IRAK2
Genomic and cartography
GoldenPath hg38 (UCSC)IRAK2  -     chr3:10164879-10243743 +  3p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRAK2  -     3p25.3   [Description]    (hg19-Feb_2009)
EnsemblIRAK2 - 3p25.3 [CytoView hg19]  IRAK2 - 3p25.3 [CytoView hg38]
Mapping of homologs : NCBIIRAK2 [Mapview hg19]  IRAK2 [Mapview hg38]
OMIM603304   
Gene and transcription
Genbank (Entrez)AF026273 AJ496794 AK299033 AK312841 AL538890
RefSeq transcript (Entrez)NM_001570
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IRAK2
Cluster EST : UnigeneHs.449207 [ NCBI ]
CGAP (NCI)Hs.449207
Alternative Splicing GalleryENSG00000134070
Gene ExpressionIRAK2 [ NCBI-GEO ]   IRAK2 [ EBI - ARRAY_EXPRESS ]   IRAK2 [ SEEK ]   IRAK2 [ MEM ]
Gene Expression Viewer (FireBrowse)IRAK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3656
GTEX Portal (Tissue expression)IRAK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43187   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43187  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43187
Splice isoforms : SwissVarO43187
PhosPhoSitePlusO43187
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    IRAK2    Kinase-like_dom    Prot_kinase_dom   
Domain families : Pfam (Sanger)Death (PF00531)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00531    pfam00069   
Conserved Domain (NCBI)IRAK2
DMDM Disease mutations3656
Blocks (Seattle)IRAK2
PDB (SRS)3MOP   
PDB (PDBSum)3MOP   
PDB (IMB)3MOP   
PDB (RSDB)3MOP   
Structural Biology KnowledgeBase3MOP   
SCOP (Structural Classification of Proteins)3MOP   
CATH (Classification of proteins structures)3MOP   
SuperfamilyO43187
Human Protein AtlasENSG00000134070
Peptide AtlasO43187
HPRD04491
IPIIPI00304986   
Protein Interaction databases
DIP (DOE-UCLA)O43187
IntAct (EBI)O43187
FunCoupENSG00000134070
BioGRIDIRAK2
STRING (EMBL)IRAK2
ZODIACIRAK2
Ontologies - Pathways
QuickGOO43187
Ontology : AmiGOactivation of MAPK activity  regulation of cytokine-mediated signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  protein phosphorylation  inflammatory response  I-kappaB kinase/NF-kappaB signaling  JNK cascade  endosome membrane  lipopolysaccharide-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  toll-like receptor 9 signaling pathway  intracellular signal transduction  protein homodimerization activity  protein heterodimerization activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  response to interleukin-1  
Ontology : EGO-EBIactivation of MAPK activity  regulation of cytokine-mediated signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  protein phosphorylation  inflammatory response  I-kappaB kinase/NF-kappaB signaling  JNK cascade  endosome membrane  lipopolysaccharide-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  toll-like receptor 9 signaling pathway  intracellular signal transduction  protein homodimerization activity  protein heterodimerization activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  response to interleukin-1  
Pathways : BIOCARTASignal transduction through IL1R [Genes]   
Pathways : KEGGApoptosis    Neurotrophin signaling pathway    Tuberculosis   
NDEx NetworkIRAK2
Atlas of Cancer Signalling NetworkIRAK2
Wikipedia pathwaysIRAK2
Orthology - Evolution
OrthoDB3656
GeneTree (enSembl)ENSG00000134070
Phylogenetic Trees/Animal Genes : TreeFamIRAK2
HOVERGENO43187
HOGENOMO43187
Homologs : HomoloGeneIRAK2
Homology/Alignments : Family Browser (UCSC)IRAK2
Gene fusions - Rearrangements
Fusion : MitelmanIRAK2/SRGAP3 [3p25.3/3p25.3]  
Fusion: TCGAIRAK2 3p25.3 SRGAP3 3p25.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRAK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRAK2
dbVarIRAK2
ClinVarIRAK2
1000_GenomesIRAK2 
Exome Variant ServerIRAK2
ExAC (Exome Aggregation Consortium)IRAK2 (select the gene name)
Genetic variants : HAPMAP3656
Genomic Variants (DGV)IRAK2 [DGVbeta]
DECIPHERIRAK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRAK2 
Mutations
ICGC Data PortalIRAK2 
TCGA Data PortalIRAK2 
Broad Tumor PortalIRAK2
OASIS PortalIRAK2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDIRAK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IRAK2
DgiDB (Drug Gene Interaction Database)IRAK2
DoCM (Curated mutations)IRAK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRAK2 (select a term)
intoGenIRAK2
Cancer3DIRAK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603304   
Orphanet
MedgenIRAK2
Genetic Testing Registry IRAK2
NextProtO43187 [Medical]
TSGene3656
GENETestsIRAK2
Target ValidationIRAK2
Huge Navigator IRAK2 [HugePedia]
snp3D : Map Gene to Disease3656
BioCentury BCIQIRAK2
ClinGenIRAK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3656
Chemical/Pharm GKB GenePA29913
Clinical trialIRAK2
Miscellaneous
canSAR (ICR)IRAK2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRAK2
EVEXIRAK2
GoPubMedIRAK2
iHOPIRAK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:04:11 CEST 2017

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