IRAK2 (interleukin-1 receptor-associated kinase 2)

Identity

Other names	IRAK-2
	MGC150550
HGNC	IRAK2
Location	3p25.3
Location_base_pair	Starts at 10181563 and ends at 10260427 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	IRAK2   6113
Entrez_Gene	IRAK2  3656  interleukin-1 receptor-associated kinase 2
	Cards
GeneCards	IRAK2
Ensembl	IRAK2 [Search_View]   ENSG00000134070 [Gene_View]
Genatlas	IRAK2
GeneLynx	IRAK2
eGenome	IRAK2
euGene	3656
	Genomic and cartography
GoldenPath	IRAK2  -  3p25.3   chr3:10181563-10260427 +  3p25.3   [Description]    (hg18-March_2006)
Ensembl	IRAK2 - 3p25.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	IRAK2
	Gene and transcription
Genbank	AF026273 [ ENTREZ ]
Genbank	AJ496794 [ ENTREZ ]
Genbank	AK299033 [ ENTREZ ]
Genbank	AK312841 [ ENTREZ ]
Genbank	AL538890 [ ENTREZ ]
RefSeq	NM_001570 [ SRS ]    NM_001570 [ ENTREZ ]
RefSeq	AC_000046 [ SRS ]    AC_000046 [ ENTREZ ]
RefSeq	AC_000135 [ SRS ]    AC_000135 [ ENTREZ ]
RefSeq	NC_000003 [ SRS ]    NC_000003 [ ENTREZ ]
RefSeq	NT_022517 [ SRS ]    NT_022517 [ ENTREZ ]
RefSeq	NW_001838876 [ SRS ]    NW_001838876 [ ENTREZ ]
RefSeq	NW_921651 [ SRS ]    NW_921651 [ ENTREZ ]
AceView	IRAK2 AceView - NCBI
Unigene	Hs.449207 [ SRS ]    Hs.449207 [ NCBI ]     HS449207 [ spliceNest ]
Fast-db	1879 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O43187 [ SRS]    O43187 [ EXPASY ]     O43187 [ INTERPRO ]     O43187 [ UNIPROT ]
Prosite	PS50017 DEATH_DOMAIN [ SRS ]    PS50017 DEATH_DOMAIN [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000488 Death [ SRS ]    IPR000488 Death [ EBI ]
Interpro	IPR011029 DEATH_like [ SRS ]    IPR011029 DEATH_like [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
CluSTr	O43187
Pfam	PF00531 Death [ SRS ]    PF00531 Death [ Sanger ]    pfam00531 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O43187 IRAK2_HUMAN [ Domain structure ]   O43187 IRAK2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O43187
HPRD	04491
	Protein Interaction databases
DIP	O43187
IntAct	O43187
	Polymorphism : SNP, mutations, diseases
OMIM	603304    [ map ]
GENECLINICS	603304
SNP	IRAK2 [dbSNP-NCBI]
SNP	NM_001570 [SNP-NCI]
SNP	IRAK2 [GeneSNPs - Utah]  IRAK2] [HGBASE - SRS]
HAPMAP	IRAK2 [HAPMAP]
COSMIC	IRAK2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	IRAK2
	General knowledge
Family Browser	IRAK2 [UCSC Family Browser]
SOURCE	NM_001570
SMD	Hs.449207
SAGE	Hs.449207
GO	protein kinase activity [Amigo]  protein kinase activity
GO	NF-kappaB-inducing kinase activity [Amigo]  NF-kappaB-inducing kinase activity
GO	ATP binding [Amigo]  ATP binding
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	inflammatory response [Amigo]  inflammatory response
GO	signal transduction [Amigo]  signal transduction
GO	I-kappaB kinase/NF-kappaB cascade [Amigo]  I-kappaB kinase/NF-kappaB cascade
GO	cell surface [Amigo]  cell surface
GO	identical protein binding [Amigo]  identical protein binding
BIOCARTA	Signal transduction through IL1R    [Genes]
KEGG	Apoptosis
PubGene	IRAK2
TreeFam	IRAK2
CTD	3656 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	IRAK2 Related clones (RZPD - Berlin)
	PubMed
PubMed	11 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:46:52 2008