IRAK2 (interleukin 1 receptor associated kinase 2)

2006-10-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
IRAK-2
FUSION GENES

Other Information

Locus ID:

NCBI: 3656
MIM: 603304
HGNC: 6113
Ensembl: ENSG00000134070

Variants:

dbSNP: 3656
ClinVar: 3656
TCGA: ENSG00000134070
COSMIC: IRAK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134070ENST00000256458O43187

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
IRAK2 mediated activation of TAK1 complexREACTOMER-HSA-937042
TAK1 activates NFkB by phosphorylation and activation of IKKs complexREACTOMER-HSA-445989
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1REACTOMER-HSA-450321
activated TAK1 mediates p38 MAPK activationREACTOMER-HSA-450302
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
TRAF6 mediated induction of TAK1 complexREACTOMER-HSA-937072
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationREACTOMER-HSA-975163
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
204853412010Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.348
209378402010Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
178781612007IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202009532010Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.27
250637382014Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes.23
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19

Citation

Dessen P

IRAK2 (interleukin 1 receptor associated kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43327/irak2