Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3661
MIM: 603734
HGNC: 6118
Ensembl: ENSG00000126456
Variants:
dbSNP: 3661
ClinVar: 3661
TCGA: ENSG00000126456
COSMIC: IRF3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164722208 | MAVS | Gene | Pathway | associated | 26111151 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37725754 | 2024 | Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1. | 6 |
| 38233853 | 2024 | Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation. | 1 |
| 38316991 | 2024 | Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. | 1 |
| 38375470 | 2024 | IRF3 function and immunological gaps in sepsis. | 1 |
| 38396775 | 2024 | The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3. | 0 |
| 38556105 | 2024 | Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer. | 0 |
| 38663254 | 2024 | Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation. | 0 |
| 37725754 | 2024 | Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1. | 6 |
| 38233853 | 2024 | Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation. | 1 |
| 38316991 | 2024 | Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. | 1 |
| 38375470 | 2024 | IRF3 function and immunological gaps in sepsis. | 1 |
| 38396775 | 2024 | The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3. | 0 |
| 38556105 | 2024 | Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer. | 0 |
| 38663254 | 2024 | Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation. | 0 |
| 36861386 | 2023 | Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNβ production. | 1 |
Citation
Dessen P
IRF3 (interferon regulatory factor 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46567/irf3
