Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IRF7 (interferon regulatory factor 7)

Identity

Other aliasIMD39
IRF-7H
IRF7A
IRF7B
IRF7C
IRF7H
HGNC (Hugo) IRF7
LocusID (NCBI) 3665
Atlas_Id 43745
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 612555 and ends at 615999 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IRF7 (11p15.5) / CARS2 (13q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IRF7   6122
Cards
Entrez_Gene (NCBI)IRF7  3665  interferon regulatory factor 7
AliasesIMD39; IRF-7H; IRF7A; IRF7B; 
IRF7C; IRF7H
GeneCards (Weizmann)IRF7
Ensembl hg19 (Hinxton)ENSG00000185507 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185507 [Gene_View]  chr11:612555-615999 [Contig_View]  IRF7 [Vega]
ICGC DataPortalENSG00000185507
TCGA cBioPortalIRF7
AceView (NCBI)IRF7
Genatlas (Paris)IRF7
WikiGenes3665
SOURCE (Princeton)IRF7
Genetics Home Reference (NIH)IRF7
Genomic and cartography
GoldenPath hg38 (UCSC)IRF7  -     chr11:612555-615999 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IRF7  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblIRF7 - 11p15.5 [CytoView hg19]  IRF7 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIIRF7 [Mapview hg19]  IRF7 [Mapview hg38]
OMIM605047   616345   
Gene and transcription
Genbank (Entrez)AF076494 AK303752 BC136555 BC144242 BM849172
RefSeq transcript (Entrez)NM_001572 NM_004029 NM_004030 NM_004031
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_029106 NT_187586
Consensus coding sequences : CCDS (NCBI)IRF7
Cluster EST : UnigeneHs.166120 [ NCBI ]
CGAP (NCI)Hs.166120
Alternative Splicing GalleryENSG00000185507
Gene ExpressionIRF7 [ NCBI-GEO ]   IRF7 [ EBI - ARRAY_EXPRESS ]   IRF7 [ SEEK ]   IRF7 [ MEM ]
Gene Expression Viewer (FireBrowse)IRF7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3665
GTEX Portal (Tissue expression)IRF7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92985   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92985  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92985
Splice isoforms : SwissVarQ92985
PhosPhoSitePlusQ92985
Domaine pattern : Prosite (Expaxy)IRF_1 (PS00601)    IRF_2 (PS51507)   
Domains : Interpro (EBI)Interferon_reg_fac_CS    Interferon_reg_fact_DNA-bd_dom    Interferon_reg_factor-3    SMAD_dom-like    SMAD_FHA_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)IRF (PF00605)    IRF-3 (PF10401)   
Domain families : Pfam (NCBI)pfam00605    pfam10401   
Domain families : Smart (EMBL)IRF (SM00348)  IRF-3 (SM01243)  
Conserved Domain (NCBI)IRF7
DMDM Disease mutations3665
Blocks (Seattle)IRF7
PDB (SRS)2O61   
PDB (PDBSum)2O61   
PDB (IMB)2O61   
PDB (RSDB)2O61   
Structural Biology KnowledgeBase2O61   
SCOP (Structural Classification of Proteins)2O61   
CATH (Classification of proteins structures)2O61   
SuperfamilyQ92985
Human Protein AtlasENSG00000185507
Peptide AtlasQ92985
HPRD05441
IPIIPI00024379   IPI00298039   IPI00219144   IPI00298041   IPI00978895   IPI00976831   IPI00980867   IPI00978186   
Protein Interaction databases
DIP (DOE-UCLA)Q92985
IntAct (EBI)Q92985
FunCoupENSG00000185507
BioGRIDIRF7
STRING (EMBL)IRF7
ZODIACIRF7
Ontologies - Pathways
QuickGOQ92985
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  regulation of adaptive immune response  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  response to virus  endosome membrane  immunoglobulin mediated immune response  establishment of viral latency  regulation of type I interferon production  positive regulation of type I interferon production  interferon-alpha production  interferon-beta production  positive regulation of interferon-alpha production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  regulation of MyD88-dependent toll-like receptor signaling pathway  regulation of MyD88-independent toll-like receptor signaling pathway  TRIF-dependent toll-like receptor signaling pathway  MDA-5 signaling pathway  innate immune response  type I interferon biosynthetic process  regulation of monocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  regulation of immune response  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  positive regulation of type I interferon-mediated signaling pathway  negative regulation of macrophage apoptotic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  regulation of adaptive immune response  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  response to virus  endosome membrane  immunoglobulin mediated immune response  establishment of viral latency  regulation of type I interferon production  positive regulation of type I interferon production  interferon-alpha production  interferon-beta production  positive regulation of interferon-alpha production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  regulation of MyD88-dependent toll-like receptor signaling pathway  regulation of MyD88-independent toll-like receptor signaling pathway  TRIF-dependent toll-like receptor signaling pathway  MDA-5 signaling pathway  innate immune response  type I interferon biosynthetic process  regulation of monocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  regulation of immune response  interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  positive regulation of type I interferon-mediated signaling pathway  negative regulation of macrophage apoptotic process  
Pathways : BIOCARTAThe information-processing pathway at the IFN-beta enhancer [Genes]   
Pathways : KEGG   
NDEx NetworkIRF7
Atlas of Cancer Signalling NetworkIRF7
Wikipedia pathwaysIRF7
Orthology - Evolution
OrthoDB3665
GeneTree (enSembl)ENSG00000185507
Phylogenetic Trees/Animal Genes : TreeFamIRF7
HOVERGENQ92985
HOGENOMQ92985
Homologs : HomoloGeneIRF7
Homology/Alignments : Family Browser (UCSC)IRF7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIRF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IRF7
dbVarIRF7
ClinVarIRF7
1000_GenomesIRF7 
Exome Variant ServerIRF7
ExAC (Exome Aggregation Consortium)IRF7 (select the gene name)
Genetic variants : HAPMAP3665
Genomic Variants (DGV)IRF7 [DGVbeta]
DECIPHERIRF7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIRF7 
Mutations
ICGC Data PortalIRF7 
TCGA Data PortalIRF7 
Broad Tumor PortalIRF7
OASIS PortalIRF7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIRF7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIRF7
intOGen PortalIRF7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IRF7
DgiDB (Drug Gene Interaction Database)IRF7
DoCM (Curated mutations)IRF7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IRF7 (select a term)
intoGenIRF7
Cancer3DIRF7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605047    616345   
Orphanet
MedgenIRF7
Genetic Testing Registry IRF7
NextProtQ92985 [Medical]
TSGene3665
GENETestsIRF7
Target ValidationIRF7
Huge Navigator IRF7 [HugePedia]
snp3D : Map Gene to Disease3665
BioCentury BCIQIRF7
ClinGenIRF7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3665
Chemical/Pharm GKB GenePA29921
Clinical trialIRF7
Miscellaneous
canSAR (ICR)IRF7 (select the gene name)
Probes
Litterature
PubMed142 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIRF7
EVEXIRF7
GoPubMedIRF7
iHOPIRF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:38:48 CEST 2017

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