ITGAV (integrin subunit alpha V)

2003-08-01  

Identity

HGNC
LOCATION
2q32.1
LOCUSID
ALIAS
CD51,MSK8,VNRA,VTNR
FUSION GENES

Other Information

Locus ID:

NCBI: 3685
MIM: 193210
HGNC: 6150
Ensembl: ENSG00000138448

Variants:

dbSNP: 3685
ClinVar: 3685
TCGA: ENSG00000138448
COSMIC: ITGAV

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138448ENST00000261023P06756
ENSG00000138448ENST00000261023L7RXH0
ENSG00000138448ENST00000374907P06756
ENSG00000138448ENST00000430709H7BZG1
ENSG00000138448ENST00000433736P06756

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Cell adhesion molecules (CAMs)KEGGko04514
Regulation of actin cytoskeletonKEGGko04810
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Cell adhesion molecules (CAMs)KEGGhsa04514
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Thyroid hormone signaling pathwayKEGGhsa04919
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Cross-presentation of particulate exogenous antigens (phagosomes)REACTOMER-HSA-1236973
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
PECAM1 interactionsREACTOMER-HSA-210990
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Syndecan interactionsREACTOMER-HSA-3000170
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Signal transduction by L1REACTOMER-HSA-445144
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180843012008Modification of kidney barrier function by the urokinase receptor.183
237760772013PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion.160
126822932003Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins.124
158344252005Integrin alphavbeta3 is a coreceptor for human cytomegalovirus.116
124861082002The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis.105
176412252007Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis.103
192551472009Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.95
128743882003Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
168186912006Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man.84

Citation

Dessen P

ITGAV (integrin subunit alpha V)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41015/itgav