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ITPKA (inositol-trisphosphate 3-kinase A)

Identity

Alias_namesinositol 1
Alias_symbol (synonym)IP3KA
IP3-3KA
Other alias
HGNC (Hugo) ITPKA
LocusID (NCBI) 3706
Atlas_Id 45875
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 41493858 and ends at 41503559 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ITPKA (15q15.1) / ITPKA (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ITPKA   6178
Cards
Entrez_Gene (NCBI)ITPKA  3706  inositol-trisphosphate 3-kinase A
AliasesIP3-3KA; IP3KA
GeneCards (Weizmann)ITPKA
Ensembl hg19 (Hinxton)ENSG00000137825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137825 [Gene_View]  chr15:41493858-41503559 [Contig_View]  ITPKA [Vega]
ICGC DataPortalENSG00000137825
TCGA cBioPortalITPKA
AceView (NCBI)ITPKA
Genatlas (Paris)ITPKA
WikiGenes3706
SOURCE (Princeton)ITPKA
Genetics Home Reference (NIH)ITPKA
Genomic and cartography
GoldenPath hg38 (UCSC)ITPKA  -     chr15:41493858-41503559 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ITPKA  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblITPKA - 15q15.1 [CytoView hg19]  ITPKA - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBIITPKA [Mapview hg19]  ITPKA [Mapview hg38]
OMIM147521   
Gene and transcription
Genbank (Entrez)BC026331 DB543073 X54938
RefSeq transcript (Entrez)NM_002220
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ITPKA
Cluster EST : UnigeneHs.2722 [ NCBI ]
CGAP (NCI)Hs.2722
Alternative Splicing GalleryENSG00000137825
Gene ExpressionITPKA [ NCBI-GEO ]   ITPKA [ EBI - ARRAY_EXPRESS ]   ITPKA [ SEEK ]   ITPKA [ MEM ]
Gene Expression Viewer (FireBrowse)ITPKA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3706
GTEX Portal (Tissue expression)ITPKA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23677   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23677  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23677
Splice isoforms : SwissVarP23677
Catalytic activity : Enzyme2.7.1.127 [ Enzyme-Expasy ]   2.7.1.1272.7.1.127 [ IntEnz-EBI ]   2.7.1.127 [ BRENDA ]   2.7.1.127 [ KEGG ]   
PhosPhoSitePlusP23677
Domains : Interpro (EBI)IPK   
Domain families : Pfam (Sanger)IPK (PF03770)   
Domain families : Pfam (NCBI)pfam03770   
Conserved Domain (NCBI)ITPKA
DMDM Disease mutations3706
Blocks (Seattle)ITPKA
PDB (SRS)1W2C    1W2D    1W2F    4UPU   
PDB (PDBSum)1W2C    1W2D    1W2F    4UPU   
PDB (IMB)1W2C    1W2D    1W2F    4UPU   
PDB (RSDB)1W2C    1W2D    1W2F    4UPU   
Structural Biology KnowledgeBase1W2C    1W2D    1W2F    4UPU   
SCOP (Structural Classification of Proteins)1W2C    1W2D    1W2F    4UPU   
CATH (Classification of proteins structures)1W2C    1W2D    1W2F    4UPU   
SuperfamilyP23677
Human Protein AtlasENSG00000137825
Peptide AtlasP23677
HPRD00941
IPIIPI00012538   IPI00790078   
Protein Interaction databases
DIP (DOE-UCLA)P23677
IntAct (EBI)P23677
FunCoupENSG00000137825
BioGRIDITPKA
STRING (EMBL)ITPKA
ZODIACITPKA
Ontologies - Pathways
QuickGOP23677
Ontology : AmiGOcalmodulin-dependent protein kinase activity  calmodulin binding  ATP binding  cytosol  inositol metabolic process  protein phosphorylation  signal transduction  inositol-1,4,5-trisphosphate 3-kinase activity  actin cytoskeleton organization  dendritic spine  inositol phosphate metabolic process  regulation of synaptic plasticity  Rac GTPase binding  positive regulation of dendritic spine morphogenesis  dendritic spine maintenance  
Ontology : EGO-EBIcalmodulin-dependent protein kinase activity  calmodulin binding  ATP binding  cytosol  inositol metabolic process  protein phosphorylation  signal transduction  inositol-1,4,5-trisphosphate 3-kinase activity  actin cytoskeleton organization  dendritic spine  inositol phosphate metabolic process  regulation of synaptic plasticity  Rac GTPase binding  positive regulation of dendritic spine morphogenesis  dendritic spine maintenance  
Pathways : KEGGInositol phosphate metabolism    Calcium signaling pathway    Phosphatidylinositol signaling system   
NDEx NetworkITPKA
Atlas of Cancer Signalling NetworkITPKA
Wikipedia pathwaysITPKA
Orthology - Evolution
OrthoDB3706
GeneTree (enSembl)ENSG00000137825
Phylogenetic Trees/Animal Genes : TreeFamITPKA
HOVERGENP23677
HOGENOMP23677
Homologs : HomoloGeneITPKA
Homology/Alignments : Family Browser (UCSC)ITPKA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerITPKA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ITPKA
dbVarITPKA
ClinVarITPKA
1000_GenomesITPKA 
Exome Variant ServerITPKA
ExAC (Exome Aggregation Consortium)ITPKA (select the gene name)
Genetic variants : HAPMAP3706
Genomic Variants (DGV)ITPKA [DGVbeta]
DECIPHERITPKA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisITPKA 
Mutations
ICGC Data PortalITPKA 
TCGA Data PortalITPKA 
Broad Tumor PortalITPKA
OASIS PortalITPKA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICITPKA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDITPKA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ITPKA
DgiDB (Drug Gene Interaction Database)ITPKA
DoCM (Curated mutations)ITPKA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ITPKA (select a term)
intoGenITPKA
Cancer3DITPKA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147521   
Orphanet
MedgenITPKA
Genetic Testing Registry ITPKA
NextProtP23677 [Medical]
TSGene3706
GENETestsITPKA
Huge Navigator ITPKA [HugePedia]
snp3D : Map Gene to Disease3706
BioCentury BCIQITPKA
ClinGenITPKA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3706
Chemical/Pharm GKB GenePA29975
Clinical trialITPKA
Miscellaneous
canSAR (ICR)ITPKA (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineITPKA
EVEXITPKA
GoPubMedITPKA
iHOPITPKA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:20:57 CEST 2017

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