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KAT2B (lysine acetyltransferase 2B)

Identity

Alias_namesPCAF
p300/CBP-associated factor
K(lysine) acetyltransferase 2B
Alias_symbol (synonym)P/CAF
GCN5
GCN5L
Other aliasCAF
HGNC (Hugo) KAT2B
LocusID (NCBI) 8850
Atlas_Id 41654
Location 3p24.3  [Link to chromosome band 3p24]
Location_base_pair Starts at 20040032 and ends at 20154404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KAT2B (3p24.3) / CNIH2 (11q13.2)KAT2B (3p24.3) / KAT2B (3p24.3)LLPH (12q14.3) / KAT2B (3p24.3)
LOC100132167 (9p11.2) / KAT2B (3p24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  inv(3)(p24q26) ?/MECOM
inv(3)(q21q26) RPN1/MECOM
t(3;7)(q26;q21) CDK6/MECOM
t(3;21)(q26;q11) NRIP1/MECOM


External links

Nomenclature
HGNC (Hugo)KAT2B   8638
Cards
Entrez_Gene (NCBI)KAT2B  8850  lysine acetyltransferase 2B
AliasesCAF; P/CAF; PCAF
GeneCards (Weizmann)KAT2B
Ensembl hg19 (Hinxton)ENSG00000114166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114166 [Gene_View]  chr3:20040032-20154404 [Contig_View]  KAT2B [Vega]
ICGC DataPortalENSG00000114166
TCGA cBioPortalKAT2B
AceView (NCBI)KAT2B
Genatlas (Paris)KAT2B
WikiGenes8850
SOURCE (Princeton)KAT2B
Genetics Home Reference (NIH)KAT2B
Genomic and cartography
GoldenPath hg38 (UCSC)KAT2B  -     chr3:20040032-20154404 +  3p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KAT2B  -     3p24.3   [Description]    (hg19-Feb_2009)
EnsemblKAT2B - 3p24.3 [CytoView hg19]  KAT2B - 3p24.3 [CytoView hg38]
Mapping of homologs : NCBIKAT2B [Mapview hg19]  KAT2B [Mapview hg38]
OMIM602303   
Gene and transcription
Genbank (Entrez)AL832173 BC060823 BC070075 U57317
RefSeq transcript (Entrez)NM_003884
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KAT2B
Cluster EST : UnigeneHs.533055 [ NCBI ]
CGAP (NCI)Hs.533055
Alternative Splicing GalleryENSG00000114166
Gene ExpressionKAT2B [ NCBI-GEO ]   KAT2B [ EBI - ARRAY_EXPRESS ]   KAT2B [ SEEK ]   KAT2B [ MEM ]
Gene Expression Viewer (FireBrowse)KAT2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8850
GTEX Portal (Tissue expression)KAT2B
Human Protein AtlasENSG00000114166-KAT2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92831   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92831  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92831
Splice isoforms : SwissVarQ92831
Catalytic activity : Enzyme2.3.1.48 [ Enzyme-Expasy ]   2.3.1.482.3.1.48 [ IntEnz-EBI ]   2.3.1.48 [ BRENDA ]   2.3.1.48 [ KEGG ]   
PhosPhoSitePlusQ92831
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    GNAT (PS51186)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    Bromodomain    Bromodomain_CS    GNAT_dom    Hist_acetylase_PCAF    PCAF_N   
Domain families : Pfam (Sanger)Acetyltransf_1 (PF00583)    Bromodomain (PF00439)    PCAF_N (PF06466)   
Domain families : Pfam (NCBI)pfam00583    pfam00439    pfam06466   
Domain families : Smart (EMBL)BROMO (SM00297)  
Conserved Domain (NCBI)KAT2B
DMDM Disease mutations8850
Blocks (Seattle)KAT2B
PDB (SRS)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
PDB (PDBSum)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
PDB (IMB)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
PDB (RSDB)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
Structural Biology KnowledgeBase1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
SCOP (Structural Classification of Proteins)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
CATH (Classification of proteins structures)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR   
SuperfamilyQ92831
Human Protein Atlas [tissue]ENSG00000114166-KAT2B [tissue]
Peptide AtlasQ92831
HPRD06780
IPIIPI00022055   
Protein Interaction databases
DIP (DOE-UCLA)Q92831
IntAct (EBI)Q92831
FunCoupENSG00000114166
BioGRIDKAT2B
STRING (EMBL)KAT2B
ZODIACKAT2B
Ontologies - Pathways
QuickGOQ92831
Ontology : AmiGOPCAF complex  kinetochore  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription cofactor activity  transcription coactivator activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  chromatin remodeling  chromatin remodeling  transcription initiation from RNA polymerase II promoter  protein acetylation  cell cycle arrest  Notch signaling pathway  transcription factor binding  negative regulation of cell proliferation  regulation of protein ADP-ribosylation  viral process  acetyltransferase activity  protein deubiquitination  N-terminal peptidyl-lysine acetylation  internal peptidyl-lysine acetylation  peptidyl-lysine acetylation  protein kinase binding  A band  I band  protein complex binding  cellular response to insulin stimulus  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  actomyosin  histone deacetylase binding  histone H3 acetylation  histone H3-K9 acetylation  negative regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of gene expression, epigenetic  positive regulation of transcription from RNA polymerase II promoter  rhythmic process  
Ontology : EGO-EBIPCAF complex  kinetochore  RNA polymerase II regulatory region sequence-specific DNA binding  chromatin binding  transcription cofactor activity  transcription coactivator activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  chromatin remodeling  chromatin remodeling  transcription initiation from RNA polymerase II promoter  protein acetylation  cell cycle arrest  Notch signaling pathway  transcription factor binding  negative regulation of cell proliferation  regulation of protein ADP-ribosylation  viral process  acetyltransferase activity  protein deubiquitination  N-terminal peptidyl-lysine acetylation  internal peptidyl-lysine acetylation  peptidyl-lysine acetylation  protein kinase binding  A band  I band  protein complex binding  cellular response to insulin stimulus  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  actomyosin  histone deacetylase binding  histone H3 acetylation  histone H3-K9 acetylation  negative regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of gene expression, epigenetic  positive regulation of transcription from RNA polymerase II promoter  rhythmic process  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGNotch signaling pathway    Thyroid hormone signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkKAT2B
Atlas of Cancer Signalling NetworkKAT2B
Wikipedia pathwaysKAT2B
Orthology - Evolution
OrthoDB8850
GeneTree (enSembl)ENSG00000114166
Phylogenetic Trees/Animal Genes : TreeFamKAT2B
HOVERGENQ92831
HOGENOMQ92831
Homologs : HomoloGeneKAT2B
Homology/Alignments : Family Browser (UCSC)KAT2B
Gene fusions - Rearrangements
Fusion: Tumor Portal KAT2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKAT2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KAT2B
dbVarKAT2B
ClinVarKAT2B
1000_GenomesKAT2B 
Exome Variant ServerKAT2B
ExAC (Exome Aggregation Consortium)ENSG00000114166
GNOMAD BrowserENSG00000114166
Genetic variants : HAPMAP8850
Genomic Variants (DGV)KAT2B [DGVbeta]
DECIPHERKAT2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKAT2B 
Mutations
ICGC Data PortalKAT2B 
TCGA Data PortalKAT2B 
Broad Tumor PortalKAT2B
OASIS PortalKAT2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKAT2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKAT2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KAT2B
DgiDB (Drug Gene Interaction Database)KAT2B
DoCM (Curated mutations)KAT2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KAT2B (select a term)
intoGenKAT2B
Cancer3DKAT2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602303   
Orphanet
MedgenKAT2B
Genetic Testing Registry KAT2B
NextProtQ92831 [Medical]
TSGene8850
GENETestsKAT2B
Target ValidationKAT2B
Huge Navigator KAT2B [HugePedia]
snp3D : Map Gene to Disease8850
BioCentury BCIQKAT2B
ClinGenKAT2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8850
Chemical/Pharm GKB GenePA162392705
Clinical trialKAT2B
Miscellaneous
canSAR (ICR)KAT2B (select the gene name)
Probes
Litterature
PubMed327 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKAT2B
EVEXKAT2B
GoPubMedKAT2B
iHOPKAT2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:55:01 CET 2017

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