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KAT2B (lysine acetyltransferase 2B)

Identity

Alias (NCBI)CAF
P/CAF
PCAF
HGNC (Hugo) KAT2B
HGNC Alias symbP/CAF
GCN5
GCN5L
HGNC Previous namePCAF
HGNC Previous namep300/CBP-associated factor
 K(lysine) acetyltransferase 2B
LocusID (NCBI) 8850
Atlas_Id 41654
Location 3p24.3  [Link to chromosome band 3p24]
Location_base_pair Starts at 20040446 and ends at 20154404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KAT2B (3p24.3) / CNIH2 (11q13.2)KAT2B (3p24.3) / KAT2B (3p24.3)LLPH (12q14.3) / KAT2B (3p24.3)
LOC100132167 (9p11.2) / KAT2B (3p24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  inv(3)(p24q26) ?/MECOM
inv(3)(q21q26) RPN1/MECOM
t(3;5)(q26;q31) H2AFY/MECOM
t(3;7)(q26;q21) CDK6/MECOM
t(3;21)(q26;q11) NRIP1/MECOM


External links

 

Nomenclature
HGNC (Hugo)KAT2B   8638
Cards
Entrez_Gene (NCBI)KAT2B    lysine acetyltransferase 2B
AliasesCAF; P/CAF; PCAF
GeneCards (Weizmann)KAT2B
Ensembl hg19 (Hinxton)ENSG00000114166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114166 [Gene_View]  ENSG00000114166 [Sequence]  chr3:20040446-20154404 [Contig_View]  KAT2B [Vega]
ICGC DataPortalENSG00000114166
TCGA cBioPortalKAT2B
AceView (NCBI)KAT2B
Genatlas (Paris)KAT2B
SOURCE (Princeton)KAT2B
Genetics Home Reference (NIH)KAT2B
Genomic and cartography
GoldenPath hg38 (UCSC)KAT2B  -     chr3:20040446-20154404 +  3p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KAT2B  -     3p24.3   [Description]    (hg19-Feb_2009)
GoldenPathKAT2B - 3p24.3 [CytoView hg19]  KAT2B - 3p24.3 [CytoView hg38]
ImmunoBaseENSG00000114166
Genome Data Viewer NCBIKAT2B [Mapview hg19]  
OMIM602303   
Gene and transcription
Genbank (Entrez)AL832173 BC060823 BC070075 U57317
RefSeq transcript (Entrez)NM_003884
Consensus coding sequences : CCDS (NCBI)KAT2B
Gene ExpressionKAT2B [ NCBI-GEO ]   KAT2B [ EBI - ARRAY_EXPRESS ]   KAT2B [ SEEK ]   KAT2B [ MEM ]
Gene Expression Viewer (FireBrowse)KAT2B [ Firebrowse - Broad ]
GenevisibleExpression of KAT2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8850
GTEX Portal (Tissue expression)KAT2B
Human Protein AtlasENSG00000114166-KAT2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92831   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92831  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92831
PhosPhoSitePlusQ92831
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_1 (PS00633)    BROMODOMAIN_2 (PS50014)    GNAT (PS51186)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    Bromodomain    Bromodomain-like_sf    Bromodomain_CS    GCN5    GCN5/PCAF    GNAT_dom    PCAF_N   
Domain families : Pfam (Sanger)Acetyltransf_1 (PF00583)    Bromodomain (PF00439)    PCAF_N (PF06466)   
Domain families : Pfam (NCBI)pfam00583    pfam00439    pfam06466   
Domain families : Smart (EMBL)BROMO (SM00297)  
Conserved Domain (NCBI)KAT2B
PDB (RSDB)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
PDB Europe1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
PDB (PDBSum)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
PDB (IMB)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
Structural Biology KnowledgeBase1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
SCOP (Structural Classification of Proteins)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
CATH (Classification of proteins structures)1CM0    1JM4    1N72    1WUG    1WUM    1ZS5    2RNW    2RNX    3GG3    4NSQ    5FDZ    5FE0    5FE1    5FE2    5FE3    5FE4    5FE5    5FE6    5FE7    5FE8    5FE9    5LVQ    5LVR    5MKX    6J3O   
SuperfamilyQ92831
AlphaFold pdb e-kbQ92831   
Human Protein Atlas [tissue]ENSG00000114166-KAT2B [tissue]
HPRD06780
Protein Interaction databases
DIP (DOE-UCLA)Q92831
IntAct (EBI)Q92831
BioGRIDKAT2B
STRING (EMBL)KAT2B
ZODIACKAT2B
Ontologies - Pathways
QuickGOQ92831
Ontology : AmiGOPCAF complex  kinetochore  RNA polymerase II transcription regulatory region sequence-specific DNA binding  chromatin binding  transcription coregulator activity  transcription coactivator activity  diamine N-acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  centrosome  cytosol  chromatin remodeling  chromatin remodeling  transcription initiation from RNA polymerase II promoter  protein acetylation  cell cycle  Notch signaling pathway  positive regulation of transcription of Notch receptor target  heart development  transcription factor binding  negative regulation of cell population proliferation  regulation of protein ADP-ribosylation  acetyltransferase activity  protein deubiquitination  N-terminal peptidyl-lysine acetylation  internal peptidyl-lysine acetylation  peptidyl-lysine acetylation  protein kinase binding  A band  I band  cellular response to insulin stimulus  protein-containing complex  protein-containing complex  actomyosin  histone deacetylase binding  histone H3 acetylation  histone H3-K9 acetylation  regulation of megakaryocyte differentiation  positive regulation of gluconeogenesis  negative regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of Notch signaling pathway  positive regulation of gene expression, epigenetic  positive regulation of transcription by RNA polymerase II  negative regulation of centriole replication  rhythmic process  regulation of cell cycle  limb development  peptide-lysine-N-acetyltransferase activity  negative regulation of rRNA processing  
Ontology : EGO-EBIPCAF complex  kinetochore  RNA polymerase II transcription regulatory region sequence-specific DNA binding  chromatin binding  transcription coregulator activity  transcription coactivator activity  diamine N-acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  centrosome  cytosol  chromatin remodeling  chromatin remodeling  transcription initiation from RNA polymerase II promoter  protein acetylation  cell cycle  Notch signaling pathway  positive regulation of transcription of Notch receptor target  heart development  transcription factor binding  negative regulation of cell population proliferation  regulation of protein ADP-ribosylation  acetyltransferase activity  protein deubiquitination  N-terminal peptidyl-lysine acetylation  internal peptidyl-lysine acetylation  peptidyl-lysine acetylation  protein kinase binding  A band  I band  cellular response to insulin stimulus  protein-containing complex  protein-containing complex  actomyosin  histone deacetylase binding  histone H3 acetylation  histone H3-K9 acetylation  regulation of megakaryocyte differentiation  positive regulation of gluconeogenesis  negative regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of Notch signaling pathway  positive regulation of gene expression, epigenetic  positive regulation of transcription by RNA polymerase II  negative regulation of centriole replication  rhythmic process  regulation of cell cycle  limb development  peptide-lysine-N-acetyltransferase activity  negative regulation of rRNA processing  
Pathways : BIOCARTANuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Genes]    The information-processing pathway at the IFN-beta enhancer [Genes]    Control of Gene Expression by Vitamin D Receptor [Genes]   
Pathways : KEGGNotch signaling pathway    Thyroid hormone signaling pathway    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkKAT2B
Atlas of Cancer Signalling NetworkKAT2B
Wikipedia pathwaysKAT2B
Orthology - Evolution
OrthoDB8850
GeneTree (enSembl)ENSG00000114166
Phylogenetic Trees/Animal Genes : TreeFamKAT2B
Homologs : HomoloGeneKAT2B
Homology/Alignments : Family Browser (UCSC)KAT2B
Gene fusions - Rearrangements
Fusion : QuiverKAT2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKAT2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KAT2B
dbVarKAT2B
ClinVarKAT2B
MonarchKAT2B
1000_GenomesKAT2B 
Exome Variant ServerKAT2B
GNOMAD BrowserENSG00000114166
Varsome BrowserKAT2B
ACMGKAT2B variants
VarityQ92831
Genomic Variants (DGV)KAT2B [DGVbeta]
DECIPHERKAT2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKAT2B 
Mutations
ICGC Data PortalKAT2B 
TCGA Data PortalKAT2B 
Broad Tumor PortalKAT2B
OASIS PortalKAT2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKAT2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKAT2B
Mutations and Diseases : HGMDKAT2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKAT2B
DgiDB (Drug Gene Interaction Database)KAT2B
DoCM (Curated mutations)KAT2B
CIViC (Clinical Interpretations of Variants in Cancer)KAT2B
Cancer3DKAT2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602303   
Orphanet
DisGeNETKAT2B
MedgenKAT2B
Genetic Testing Registry KAT2B
NextProtQ92831 [Medical]
GENETestsKAT2B
Target ValidationKAT2B
Huge Navigator KAT2B [HugePedia]
ClinGenKAT2B
Clinical trials, drugs, therapy
MyCancerGenomeKAT2B
Protein Interactions : CTDKAT2B
Pharm GKB GenePA162392705
PharosQ92831
Clinical trialKAT2B
Miscellaneous
canSAR (ICR)KAT2B
HarmonizomeKAT2B
DataMed IndexKAT2B
Probes
Litterature
PubMed385 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKAT2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:14:33 CEST 2021

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