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KDM8 (lysine demethylase 8)

Identity

Alias_namesJMJD5
jumonji domain containing 5
lysine (K)-specific demethylase 8
Alias_symbol (synonym)FLJ13798
Other alias
HGNC (Hugo) KDM8
LocusID (NCBI) 79831
Atlas_Id 50701
Location 16p12.1  [Link to chromosome band 16p12]
Location_base_pair Starts at 27215296 and ends at 27233089 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KDM8   25840
Cards
Entrez_Gene (NCBI)KDM8  79831  lysine demethylase 8
AliasesJMJD5
GeneCards (Weizmann)KDM8
Ensembl hg19 (Hinxton)ENSG00000155666 [Gene_View]  chr16:27215296-27233089 [Contig_View]  KDM8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155666 [Gene_View]  chr16:27215296-27233089 [Contig_View]  KDM8 [Vega]
ICGC DataPortalENSG00000155666
TCGA cBioPortalKDM8
AceView (NCBI)KDM8
Genatlas (Paris)KDM8
WikiGenes79831
SOURCE (Princeton)KDM8
Genetics Home Reference (NIH)KDM8
Genomic and cartography
GoldenPath hg19 (UCSC)KDM8  -     chr16:27215296-27233089 +  16p12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KDM8  -     16p12.1   [Description]    (hg38-Dec_2013)
EnsemblKDM8 - 16p12.1 [CytoView hg19]  KDM8 - 16p12.1 [CytoView hg38]
Mapping of homologs : NCBIKDM8 [Mapview hg19]  KDM8 [Mapview hg38]
OMIM611917   
Gene and transcription
Genbank (Entrez)AK023860 AK225066 AK297166 AK298410 AK308499
RefSeq transcript (Entrez)NM_001145348 NM_024773
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)KDM8
Cluster EST : UnigeneHs.145717 [ NCBI ]
CGAP (NCI)Hs.145717
Alternative Splicing GalleryENSG00000155666
Gene ExpressionKDM8 [ NCBI-GEO ]   KDM8 [ EBI - ARRAY_EXPRESS ]   KDM8 [ SEEK ]   KDM8 [ MEM ]
Gene Expression Viewer (FireBrowse)KDM8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79831
GTEX Portal (Tissue expression)KDM8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N371
Splice isoforms : SwissVarQ8N371
Catalytic activity : Enzyme1.14.11.27 [ Enzyme-Expasy ]   1.14.11.271.14.11.27 [ IntEnz-EBI ]   1.14.11.27 [ BRENDA ]   1.14.11.27 [ KEGG ]   
PhosPhoSitePlusQ8N371
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)   
Domains : Interpro (EBI)JmjC_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)JmjC (SM00558)  
Conserved Domain (NCBI)KDM8
DMDM Disease mutations79831
Blocks (Seattle)KDM8
PDB (SRS)3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
PDB (PDBSum)3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
PDB (IMB)3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
PDB (RSDB)3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
Structural Biology KnowledgeBase3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
SCOP (Structural Classification of Proteins)3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
CATH (Classification of proteins structures)3UYJ    4AAP    4GAZ    4GJY    4GJZ    4QU1   
SuperfamilyQ8N371
Human Protein AtlasENSG00000155666
Peptide AtlasQ8N371
HPRD07836
IPIIPI00296340   IPI00435577   IPI00922284   IPI01009611   
Protein Interaction databases
DIP (DOE-UCLA)Q8N371
IntAct (EBI)Q8N371
FunCoupENSG00000155666
BioGRIDKDM8
STRING (EMBL)KDM8
ZODIACKDM8
Ontologies - Pathways
QuickGOQ8N371
Ontology : AmiGOG2/M transition of mitotic cell cycle  chromatin binding  nucleus  transcription, DNA-templated  positive regulation of transcription, DNA-templated  metal ion binding  histone demethylase activity (H3-K36 specific)  oxidation-reduction process  histone H3-K36 demethylation  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  chromatin binding  nucleus  transcription, DNA-templated  positive regulation of transcription, DNA-templated  metal ion binding  histone demethylase activity (H3-K36 specific)  oxidation-reduction process  histone H3-K36 demethylation  
NDEx NetworkKDM8
Atlas of Cancer Signalling NetworkKDM8
Wikipedia pathwaysKDM8
Orthology - Evolution
OrthoDB79831
GeneTree (enSembl)ENSG00000155666
Phylogenetic Trees/Animal Genes : TreeFamKDM8
HOVERGENQ8N371
HOGENOMQ8N371
Homologs : HomoloGeneKDM8
Homology/Alignments : Family Browser (UCSC)KDM8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKDM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KDM8
dbVarKDM8
ClinVarKDM8
1000_GenomesKDM8 
Exome Variant ServerKDM8
ExAC (Exome Aggregation Consortium)KDM8 (select the gene name)
Genetic variants : HAPMAP79831
Genomic Variants (DGV)KDM8 [DGVbeta]
DECIPHER (Syndromes)16:27215296-27233089  ENSG00000155666
CONAN: Copy Number AnalysisKDM8 
Mutations
ICGC Data PortalKDM8 
TCGA Data PortalKDM8 
Broad Tumor PortalKDM8
OASIS PortalKDM8 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDKDM8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KDM8
DgiDB (Drug Gene Interaction Database)KDM8
DoCM (Curated mutations)KDM8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KDM8 (select a term)
intoGenKDM8
Cancer3DKDM8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611917   
Orphanet
MedgenKDM8
Genetic Testing Registry KDM8
NextProtQ8N371 [Medical]
TSGene79831
GENETestsKDM8
Huge Navigator KDM8 [HugePedia]
snp3D : Map Gene to Disease79831
BioCentury BCIQKDM8
ClinGenKDM8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79831
Chemical/Pharm GKB GenePA143485510
Clinical trialKDM8
Miscellaneous
canSAR (ICR)KDM8 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKDM8
EVEXKDM8
GoPubMedKDM8
iHOPKDM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:11:45 CET 2017

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