Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KHK (ketohexokinase (fructokinase))

Identity

Other names-
HGNC (Hugo) KHK
LocusID (NCBI) 3795
Location 2p23.3
Location_base_pair Starts at 27309611 and ends at 27323619 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KHK   6315
Entrez_Gene (NCBI)KHK  3795  ketohexokinase (fructokinase)
Cards
GeneCards (Weizmann)KHK
Ensembl (Hinxton)ENSG00000138030 [Gene_View]  chr2:27309611-27323619 [Contig_View]  KHK [Vega]
AceView (NCBI)KHK
Genatlas (Paris)KHK
SOURCE (Stanford)NM_000221 NM_006488
Genomic and cartography
GoldenPath (UCSC)KHK  -  2p23.3   chr2:27309611-27323619 +  2p23.3   [Description]    (hg19-Feb_2009)
EnsemblKHK - 2p23.3 [CytoView]
Mapping of homologs : NCBIKHK [Mapview]
OMIM229800   614058   
Gene and transcription
Genbank (Entrez)AB209518 AK130033 AK223075 AM393286 BC006233
RefSeq transcript (SRS)NM_000221 NM_006488
RefSeq transcript (Entrez)NM_000221 NM_006488
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NG_012199 NT_022184 NW_001838768 NW_004078005
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_012199 NT_022184 NW_001838768 NW_004078005
Consensus coding sequences : CCDS (NCBI)KHK
Cluster EST : UnigeneHs.567297 [ SRS ] Hs.567297 [ NCBI ]
CGAP (NCI)Hs.567297
Alternative Splicing : Fast-db (Paris)GSHG0016324
Alternative Splicing GalleryENSG00000138030
Gene ExpressionKHK [ NCBI-GEO ]   KHK [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50053 (SRS) P50053 (Uniprot)
NextProtP50053
With graphics : InterProP50053
Splice isoforms : SwissVarP50053(Swissvar)
Domaine pattern : Prosite (SRS)PFKB_KINASES_1 (PS00583)    PFKB_KINASES_2 (PS00584)   
Domaine pattern : Prosite (Expaxy)PFKB_KINASES_1 (PS00583)    PFKB_KINASES_2 (PS00584)   
Domains : Interpro (SRS)PfkB   
Domains : Interpro (EBI)PfkB   
Related proteins : CluSTrP50053
Domain families : Pfam (SRS)PfkB (PF00294)   
Domain families : Pfam (Sanger)PfkB (PF00294)   
Domain families : Pfam (NCBI)pfam00294   
DMDM3795
Blocks (Seattle)P50053
PDB (SRS)2HLZ    2HQQ    2HW1    3B3L    3NBV    3NBW    3NC2    3NC9    3NCA    3Q92    3QA2    3QAI    3RO4   
PDB (PDBSum)2HLZ    2HQQ    2HW1    3B3L    3NBV    3NBW    3NC2    3NC9    3NCA    3Q92    3QA2    3QAI    3RO4   
PDB (IMB)2HLZ    2HQQ    2HW1    3B3L    3NBV    3NBW    3NC2    3NC9    3NCA    3Q92    3QA2    3QAI    3RO4   
PDB (RSDB)2HLZ    2HQQ    2HW1    3B3L    3NBV    3NBW    3NC2    3NC9    3NCA    3Q92    3QA2    3QAI    3RO4   
Human Protein AtlasENSG00000138030
HPRD11774
IPIIPI00029488   IPI00216136   IPI00556606   IPI00893008   
Protein Interaction databases
DIP (DOE-UCLA)P50053
IntAct (EBI)P50053
FunCoupENSG00000138030
REACTOMEKHK
Protein Interaction Database3795
BioGRIDKHK
InParanoidP50053
Interologous Interaction database P50053
IntegromeDBKHK
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KHK
SNP (GeneSNP Utah)KHK
SNP : HGBaseKHK
Genetic variants : HAPMAPKHK
Somatic Mutations in Cancer : COSMICKHK 
CONAN: Copy Number AnalysisKHK 
Mutations and Diseases : HGMDKHK
OMIM229800    614058   
GENETests229800    614058   
Disease Genetic AssociationKHK
Huge Navigator KHK [HugePedia]  KHK [HugeCancerGEM]
Genomic VariantsKHK  KHK [DGVbeta]
snp3D : Map Gene to Disease3795
General knowledge
Homologs : HomoloGeneKHK
Homology/Alignments : Family Browser (UCSC)KHK
Phylogenetic Trees/Animal Genes : TreeFamKHK
Catalytic activity : Enzyme2.7.1.3 [ Enzyme-Expasy ]   2.7.1.3 [ Enzyme-SRS ]   2.7.1.3 [ IntEnz-EBI ]   2.7.1.3 [ BRENDA ]   2.7.1.3 [ KEGG ]   
Chemical/Protein Interactions : CTD3795
Chemical/Pharm GKB GenePA30095
Clinical trialKHK
Cancer Resource (Charite)ENSG00000138030
Ontology : AmiGOketohexokinase activity  ATP binding  cytoplasm  cytosol  carbohydrate metabolic process  fructose catabolic process  response to sucrose stimulus  response to glucose stimulus  response to fructose stimulus  response to zinc ion  response to insulin stimulus  small molecule metabolic process  
Ontology : EGO-EBIketohexokinase activity  ATP binding  cytoplasm  cytosol  carbohydrate metabolic process  fructose catabolic process  response to sucrose stimulus  response to glucose stimulus  response to fructose stimulus  response to zinc ion  response to insulin stimulus  small molecule metabolic process  
Pathways : KEGGFructose and mannose metabolism
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
PubGeneKHK
iHOPKHK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:39:14 CEST 2013
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