Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KPNA2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1))

Identity

Other namesIPOA1
QIP2
RCH1
SRP1alpha
HGNC (Hugo) KPNA2
LocusID (NCBI) 3838
Location 17q24.2
Location_base_pair Starts at 66031848 and ends at 66042970 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KPNA2   6395
Cards
Entrez_Gene (NCBI)KPNA2  3838  karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
GeneCards (Weizmann)KPNA2
Ensembl (Hinxton)ENSG00000182481 [Gene_View]  chr17:66031848-66042970 [Contig_View]  KPNA2 [Vega]
ICGC DataPortalENSG00000182481
cBioPortalKPNA2
AceView (NCBI)KPNA2
Genatlas (Paris)KPNA2
WikiGenes3838
SOURCE (Princeton)NM_002266
Genomic and cartography
GoldenPath (UCSC)KPNA2  -  17q24.2   chr17:66031848-66042970 +  17q24.2   [Description]    (hg19-Feb_2009)
EnsemblKPNA2 - 17q24.2 [CytoView]
Mapping of homologs : NCBIKPNA2 [Mapview]
OMIM600685   
Gene and transcription
Genbank (Entrez)AK024833 AK058111 AK291954 BC005978 BC013257
RefSeq transcript (Entrez)NM_002266
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838454 NW_004929407
Consensus coding sequences : CCDS (NCBI)KPNA2
Cluster EST : UnigeneHs.594238 [ NCBI ]
CGAP (NCI)Hs.594238
Alternative Splicing : Fast-db (Paris)GSHG0012756
Alternative Splicing GalleryENSG00000182481
Gene ExpressionKPNA2 [ NCBI-GEO ]     KPNA2 [ SEEK ]   KPNA2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52292 (Uniprot)
NextProtP52292  [Medical]
With graphics : InterProP52292
Splice isoforms : SwissVarP52292 (Swissvar)
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like [organisation]   ARM-type_fold [organisation]   Armadillo [organisation]   Importin-a_IBB [organisation]   Importing_su_alpha [organisation]  
Related proteins : CluSTrP52292
Domain families : Pfam (Sanger)Arm (PF00514)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM Disease mutations3838
Blocks (Seattle)P52292
PDB (SRS)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
PDB (PDBSum)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
PDB (IMB)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
PDB (RSDB)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
Human Protein AtlasENSG00000182481 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP52292
HPRD02818
IPIIPI00002214   
Protein Interaction databases
DIP (DOE-UCLA)P52292
IntAct (EBI)P52292
FunCoupENSG00000182481
BioGRIDKPNA2
InParanoidP52292
Interologous Interaction database P52292
IntegromeDBKPNA2
STRING (EMBL)KPNA2
Ontologies - Pathways
Ontology : AmiGOregulation of DNA recombination  mitotic G2 phase  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  DNA metabolic process  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  viral process  cytokine-mediated signaling pathway  histone deacetylase binding  poly(A) RNA binding  
Ontology : EGO-EBIregulation of DNA recombination  mitotic G2 phase  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  DNA metabolic process  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  viral process  cytokine-mediated signaling pathway  histone deacetylase binding  poly(A) RNA binding  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Role of Ran in mitotic spindle regulation [Genes]   
Pathways : KEGGInfluenza A   
Protein Interaction DatabaseKPNA2
Wikipedia pathwaysKPNA2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KPNA2
snp3D : Map Gene to Disease3838
SNP (GeneSNP Utah)KPNA2
SNP : HGBaseKPNA2
Genetic variants : HAPMAPKPNA2
Exome VariantKPNA2
1000_GenomesKPNA2 
ICGC programENSG00000182481 
Somatic Mutations in Cancer : COSMICKPNA2 
CONAN: Copy Number AnalysisKPNA2 
Mutations and Diseases : HGMDKPNA2
Mutations and Diseases : intOGenKPNA2
Genomic VariantsKPNA2  KPNA2 [DGVbeta]
dbVarKPNA2
ClinVarKPNA2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM600685   
MedgenKPNA2
GENETestsKPNA2
Disease Genetic AssociationKPNA2
Huge Navigator KPNA2 [HugePedia]  KPNA2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneKPNA2
Homology/Alignments : Family Browser (UCSC)KPNA2
Phylogenetic Trees/Animal Genes : TreeFamKPNA2
Chemical/Protein Interactions : CTD3838
Chemical/Pharm GKB GenePA30186
Clinical trialKPNA2
Cancer Resource (Charite)ENSG00000182481
Other databases
Probes
Litterature
PubMed230 Pubmed reference(s) in Entrez
CoreMineKPNA2
iHOPKPNA2
OncoSearchKPNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:52:12 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.