Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

KPNA2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1))

Identity

Other namesIPOA1
QIP2
RCH1
SRP1alpha
HGNC (Hugo) KPNA2
LocusID (NCBI) 3838
Atlas_Id 41097
Location 17q24.2
Location_base_pair Starts at 66031848 and ends at 66042970 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KPNA2   6395
Cards
Entrez_Gene (NCBI)KPNA2  3838  karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
GeneCards (Weizmann)KPNA2
Ensembl hg19 (Hinxton)ENSG00000182481 [Gene_View]  chr17:66031848-66042970 [Contig_View]  KPNA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182481 [Gene_View]  chr17:66031848-66042970 [Contig_View]  KPNA2 [Vega]
ICGC DataPortalENSG00000182481
TCGA cBioPortalKPNA2
AceView (NCBI)KPNA2
Genatlas (Paris)KPNA2
WikiGenes3838
SOURCE (Princeton)KPNA2
Genomic and cartography
GoldenPath hg19 (UCSC)KPNA2  -     chr17:66031848-66042970 +  17q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KPNA2  -     17q24.2   [Description]    (hg38-Dec_2013)
EnsemblKPNA2 - 17q24.2 [CytoView hg19]  KPNA2 - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIKPNA2 [Mapview hg19]  KPNA2 [Mapview hg38]
OMIM600685   
Gene and transcription
Genbank (Entrez)AK024833 AK058111 AK291954 BC005978 BC013257
RefSeq transcript (Entrez)NM_002266
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)KPNA2
Cluster EST : UnigeneHs.594238 [ NCBI ]
CGAP (NCI)Hs.594238
Alternative Splicing : Fast-db (Paris)GSHG0012756
Alternative Splicing GalleryENSG00000182481
Gene ExpressionKPNA2 [ NCBI-GEO ]     KPNA2 [ SEEK ]   KPNA2 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)3838
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52292 (Uniprot)
NextProtP52292  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52292
Splice isoforms : SwissVarP52292 (Swissvar)
PhosPhoSitePlusP52292
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    Importin-a_IBB    Importing_su_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM Disease mutations3838
Blocks (Seattle)KPNA2
PDB (SRS)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
PDB (PDBSum)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
PDB (IMB)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
PDB (RSDB)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
Structural Biology KnowledgeBase1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
SCOP (Structural Classification of Proteins)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
CATH (Classification of proteins structures)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
Human Protein AtlasENSG00000182481
Peptide AtlasP52292
HPRD02818
IPIIPI00002214   
Protein Interaction databases
DIP (DOE-UCLA)P52292
IntAct (EBI)P52292
FunCoupENSG00000182481
BioGRIDKPNA2
IntegromeDBKPNA2
STRING (EMBL)KPNA2
ZODIACKPNA2
Ontologies - Pathways
QuickGOP52292
Ontology : AmiGOregulation of DNA recombination  protein binding  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  DNA metabolic process  DNA repair  double-strand break repair  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  modulation by virus of host morphology or physiology  modulation by virus of host process  viral life cycle  cytokine-mediated signaling pathway  histone deacetylase binding  poly(A) RNA binding  
Ontology : EGO-EBIregulation of DNA recombination  protein binding  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  DNA metabolic process  DNA repair  double-strand break repair  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  modulation by virus of host morphology or physiology  modulation by virus of host process  viral life cycle  cytokine-mediated signaling pathway  histone deacetylase binding  poly(A) RNA binding  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Role of Ran in mitotic spindle regulation [Genes]   
Pathways : KEGGInfluenza A   
Protein Interaction DatabaseKPNA2
Atlas of Cancer Signalling NetworkKPNA2
Wikipedia pathwaysKPNA2
Orthology - Evolution
OrthoDB3838
GeneTree (enSembl)ENSG00000182481
Phylogenetic Trees/Animal Genes : TreeFamKPNA2
Homologs : HomoloGeneKPNA2
Homology/Alignments : Family Browser (UCSC)KPNA2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKPNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA2
dbVarKPNA2
ClinVarKPNA2
1000_GenomesKPNA2 
Exome Variant ServerKPNA2
Exome Aggregation Consortium (ExAC)ENSG00000182481
SNP (GeneSNP Utah)KPNA2
SNP : HGBaseKPNA2
Genetic variants : HAPMAPKPNA2
Genomic Variants (DGV)KPNA2 [DGVbeta]
Mutations
ICGC Data PortalKPNA2 
TCGA Data PortalKPNA2 
Tumor PortalKPNA2
TCGA Copy Number PortalKPNA2
Somatic Mutations in Cancer : COSMICKPNA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KPNA2
DgiDB (Drug Gene Interaction Database)KPNA2
DoCM (Curated mutations)KPNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KPNA2 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:66031848-66042970
CONAN: Copy Number AnalysisKPNA2 
Mutations and Diseases : HGMDKPNA2
OMIM600685   
MedgenKPNA2
NextProtP52292 [Medical]
TSGene3838
GENETestsKPNA2
Huge Navigator KPNA2 [HugePedia]  KPNA2 [HugeCancerGEM]
snp3D : Map Gene to Disease3838
BioCentury BCIQKPNA2
General knowledge
Chemical/Protein Interactions : CTD3838
Chemical/Pharm GKB GenePA30186
Clinical trialKPNA2
Other databases
Probes
Litterature
PubMed250 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKPNA2
GoPubMedKPNA2
iHOPKPNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jan 16 18:53:42 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.