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KPNA2 (karyopherin subunit alpha 2)

Identity

Alias (NCBI)IPOA1
QIP2
RCH1
SRP1-alpha
SRP1alpha
HGNC (Hugo) KPNA2
HGNC Alias symbSRP1alpha
IPOA1
QIP2
HGNC Alias nameRAG cohort 1
 importin alpha 1
HGNC Previous nameRCH1
HGNC Previous namekaryopherin alpha 2 (RAG cohort 1, importin alpha 1)
 karyopherin alpha 2
LocusID (NCBI) 3838
Atlas_Id 41097
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 68035735 and ends at 68046854 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KPNA2 (17q24.2) / WBP5 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)KPNA2   6395
Cards
Entrez_Gene (NCBI)KPNA2    karyopherin subunit alpha 2
AliasesIPOA1; QIP2; RCH1; SRP1-alpha; 
SRP1alpha
GeneCards (Weizmann)KPNA2
Ensembl hg19 (Hinxton)ENSG00000182481 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182481 [Gene_View]  ENSG00000182481 [Sequence]  chr17:68035735-68046854 [Contig_View]  KPNA2 [Vega]
ICGC DataPortalENSG00000182481
TCGA cBioPortalKPNA2
AceView (NCBI)KPNA2
Genatlas (Paris)KPNA2
SOURCE (Princeton)KPNA2
Genetics Home Reference (NIH)KPNA2
Genomic and cartography
GoldenPath hg38 (UCSC)KPNA2  -     chr17:68035735-68046854 +  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KPNA2  -     17q24.2   [Description]    (hg19-Feb_2009)
GoldenPathKPNA2 - 17q24.2 [CytoView hg19]  KPNA2 - 17q24.2 [CytoView hg38]
ImmunoBaseENSG00000182481
Genome Data Viewer NCBIKPNA2 [Mapview hg19]  
OMIM600685   
Gene and transcription
Genbank (Entrez)AA744568 AK024833 AK058111 AK291954 BC005978
RefSeq transcript (Entrez)NM_001320611 NM_002266
Consensus coding sequences : CCDS (NCBI)KPNA2
Gene ExpressionKPNA2 [ NCBI-GEO ]   KPNA2 [ EBI - ARRAY_EXPRESS ]   KPNA2 [ SEEK ]   KPNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA2 [ Firebrowse - Broad ]
GenevisibleExpression of KPNA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3838
GTEX Portal (Tissue expression)KPNA2
Human Protein AtlasENSG00000182481-KPNA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52292   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52292  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52292
PhosPhoSitePlusP52292
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importin-a_IBB_sf    Importin_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)KPNA2
PDB (RSDB)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
PDB Europe1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
PDB (PDBSum)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
PDB (IMB)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
Structural Biology KnowledgeBase1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
SCOP (Structural Classification of Proteins)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
CATH (Classification of proteins structures)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6    5H43   
SuperfamilyP52292
AlphaFold pdb e-kbP52292   
Human Protein Atlas [tissue]ENSG00000182481-KPNA2 [tissue]
HPRD02818
Protein Interaction databases
DIP (DOE-UCLA)P52292
IntAct (EBI)P52292
BioGRIDKPNA2
STRING (EMBL)KPNA2
ZODIACKPNA2
Ontologies - Pathways
QuickGOP52292
Ontology : AmiGOregulation of DNA recombination  Golgi membrane  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  endoplasmic reticulum membrane  cytosol  cytosol  DNA metabolic process  double-strand break repair  NLS-bearing protein import into nucleus  NLS-bearing protein import into nucleus  nuclear localization sequence binding  nuclear localization sequence binding  membrane  modulation by virus of host cellular process  histone deacetylase binding  host cell  nuclear import signal receptor activity  entry of viral genome into host nucleus through nuclear pore complex via importin  extrinsic component of postsynaptic specialization membrane  glutamatergic synapse  glutamatergic synapse  postsynapse to nucleus signaling pathway  postsynapse to nucleus signaling pathway  positive regulation of viral life cycle  
Ontology : EGO-EBIregulation of DNA recombination  Golgi membrane  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  endoplasmic reticulum membrane  cytosol  cytosol  DNA metabolic process  double-strand break repair  NLS-bearing protein import into nucleus  NLS-bearing protein import into nucleus  nuclear localization sequence binding  nuclear localization sequence binding  membrane  modulation by virus of host cellular process  histone deacetylase binding  host cell  nuclear import signal receptor activity  entry of viral genome into host nucleus through nuclear pore complex via importin  extrinsic component of postsynaptic specialization membrane  glutamatergic synapse  glutamatergic synapse  postsynapse to nucleus signaling pathway  postsynapse to nucleus signaling pathway  positive regulation of viral life cycle  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Role of Ran in mitotic spindle regulation [Genes]   
Pathways : KEGGInfluenza A   
NDEx NetworkKPNA2
Atlas of Cancer Signalling NetworkKPNA2
Wikipedia pathwaysKPNA2
Orthology - Evolution
OrthoDB3838
GeneTree (enSembl)ENSG00000182481
Phylogenetic Trees/Animal Genes : TreeFamKPNA2
Homologs : HomoloGeneKPNA2
Homology/Alignments : Family Browser (UCSC)KPNA2
Gene fusions - Rearrangements
Fusion : QuiverKPNA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKPNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA2
dbVarKPNA2
ClinVarKPNA2
MonarchKPNA2
1000_GenomesKPNA2 
Exome Variant ServerKPNA2
GNOMAD BrowserENSG00000182481
Varsome BrowserKPNA2
ACMGKPNA2 variants
VarityP52292
Genomic Variants (DGV)KPNA2 [DGVbeta]
DECIPHERKPNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKPNA2 
Mutations
ICGC Data PortalKPNA2 
TCGA Data PortalKPNA2 
Broad Tumor PortalKPNA2
OASIS PortalKPNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DKPNA2
Mutations and Diseases : HGMDKPNA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaKPNA2
DgiDB (Drug Gene Interaction Database)KPNA2
DoCM (Curated mutations)KPNA2
CIViC (Clinical Interpretations of Variants in Cancer)KPNA2
Cancer3DKPNA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600685   
Orphanet
DisGeNETKPNA2
MedgenKPNA2
Genetic Testing Registry KPNA2
NextProtP52292 [Medical]
GENETestsKPNA2
Target ValidationKPNA2
Huge Navigator KPNA2 [HugePedia]
ClinGenKPNA2
Clinical trials, drugs, therapy
MyCancerGenomeKPNA2
Protein Interactions : CTDKPNA2
Pharm GKB GenePA30186
PharosP52292
Clinical trialKPNA2
Miscellaneous
canSAR (ICR)KPNA2
HarmonizomeKPNA2
DataMed IndexKPNA2
Probes
Litterature
PubMed401 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXKPNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:15:19 CEST 2021

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