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KPNA2 (karyopherin subunit alpha 2)

Identity

Other namesIPOA1
QIP2
RCH1
SRP1-alpha
SRP1alpha
HGNC (Hugo) KPNA2
LocusID (NCBI) 3838
Atlas_Id 41097
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 66032076 and ends at 66042975 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KPNA2 (17q24.2) / WBP5 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)KPNA2   6395
Cards
Entrez_Gene (NCBI)KPNA2  3838  karyopherin subunit alpha 2
AliasesIPOA1; QIP2; RCH1; SRP1-alpha; 
SRP1alpha
GeneCards (Weizmann)KPNA2
Ensembl hg19 (Hinxton)ENSG00000182481 [Gene_View]  chr17:66032076-66042975 [Contig_View]  KPNA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182481 [Gene_View]  chr17:66032076-66042975 [Contig_View]  KPNA2 [Vega]
ICGC DataPortalENSG00000182481
TCGA cBioPortalKPNA2
AceView (NCBI)KPNA2
Genatlas (Paris)KPNA2
WikiGenes3838
SOURCE (Princeton)KPNA2
Genomic and cartography
GoldenPath hg19 (UCSC)KPNA2  -     chr17:66032076-66042975 +  17q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KPNA2  -     17q24.2   [Description]    (hg38-Dec_2013)
EnsemblKPNA2 - 17q24.2 [CytoView hg19]  KPNA2 - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIKPNA2 [Mapview hg19]  KPNA2 [Mapview hg38]
OMIM600685   
Gene and transcription
Genbank (Entrez)AA744568 AK024833 AK058111 AK291954 BC005978
RefSeq transcript (Entrez)NM_001320611 NM_002266
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)KPNA2
Cluster EST : UnigeneHs.594238 [ NCBI ]
CGAP (NCI)Hs.594238
Alternative Splicing GalleryENSG00000182481
Gene ExpressionKPNA2 [ NCBI-GEO ]   KPNA2 [ EBI - ARRAY_EXPRESS ]   KPNA2 [ SEEK ]   KPNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)KPNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3838
GTEX Portal (Tissue expression)KPNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52292 (Uniprot)
NextProtP52292  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52292
Splice isoforms : SwissVarP52292 (Swissvar)
PhosPhoSitePlusP52292
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Arm_3    Armadillo    Importin-a_IBB    Importing_su_alpha   
Domain families : Pfam (Sanger)Arm (PF00514)    Arm_3 (PF16186)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam16186    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM Disease mutations3838
Blocks (Seattle)KPNA2
PDB (SRS)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
PDB (PDBSum)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
PDB (IMB)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
PDB (RSDB)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
Structural Biology KnowledgeBase1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
SCOP (Structural Classification of Proteins)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
CATH (Classification of proteins structures)1EFX    1QGK    1QGR    3FEX    3FEY    3WPT    4E4V    4WV6   
SuperfamilyP52292
Human Protein AtlasENSG00000182481
Peptide AtlasP52292
HPRD02818
IPIIPI00002214   
Protein Interaction databases
DIP (DOE-UCLA)P52292
IntAct (EBI)P52292
FunCoupENSG00000182481
BioGRIDKPNA2
STRING (EMBL)KPNA2
ZODIACKPNA2
Ontologies - Pathways
QuickGOP52292
Ontology : AmiGOregulation of DNA recombination  protein binding  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  DNA metabolic process  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  modulation by virus of host process  histone deacetylase binding  poly(A) RNA binding  intracellular transport of virus  
Ontology : EGO-EBIregulation of DNA recombination  protein binding  nuclear pore  nucleoplasm  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  DNA metabolic process  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  modulation by virus of host process  histone deacetylase binding  poly(A) RNA binding  intracellular transport of virus  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Role of Ran in mitotic spindle regulation [Genes]   
Pathways : KEGGInfluenza A   
NDEx NetworkKPNA2
Atlas of Cancer Signalling NetworkKPNA2
Wikipedia pathwaysKPNA2
Orthology - Evolution
OrthoDB3838
GeneTree (enSembl)ENSG00000182481
Phylogenetic Trees/Animal Genes : TreeFamKPNA2
Homologs : HomoloGeneKPNA2
Homology/Alignments : Family Browser (UCSC)KPNA2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKPNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA2
dbVarKPNA2
ClinVarKPNA2
1000_GenomesKPNA2 
Exome Variant ServerKPNA2
ExAC (Exome Aggregation Consortium)KPNA2 (select the gene name)
Genetic variants : HAPMAP3838
Genomic Variants (DGV)KPNA2 [DGVbeta]
Mutations
ICGC Data PortalKPNA2 
TCGA Data PortalKPNA2 
Broad Tumor PortalKPNA2
OASIS PortalKPNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKPNA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KPNA2
DgiDB (Drug Gene Interaction Database)KPNA2
DoCM (Curated mutations)KPNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KPNA2 (select a term)
intoGenKPNA2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:66032076-66042975  ENSG00000182481
CONAN: Copy Number AnalysisKPNA2 
Mutations and Diseases : HGMDKPNA2
OMIM600685   
MedgenKPNA2
Genetic Testing Registry KPNA2
NextProtP52292 [Medical]
TSGene3838
GENETestsKPNA2
Huge Navigator KPNA2 [HugePedia]
snp3D : Map Gene to Disease3838
BioCentury BCIQKPNA2
ClinGenKPNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3838
Chemical/Pharm GKB GenePA30186
Clinical trialKPNA2
Miscellaneous
canSAR (ICR)KPNA2 (select the gene name)
Probes
Litterature
PubMed259 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKPNA2
EVEXKPNA2
GoPubMedKPNA2
iHOPKPNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:56:52 CEST 2016

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