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KPNA2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1))

Identity

Other namesIPOA1
QIP2
RCH1
SRP1alpha
HGNC (Hugo) KPNA2
LocusID (NCBI) 3838
Location 17q24.2
Location_base_pair Starts at 66031848 and ends at 66042970 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KPNA2   6395
Cards
Entrez_Gene (NCBI)KPNA2  3838  karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
GeneCards (Weizmann)KPNA2
Ensembl hg19 (Hinxton)ENSG00000182481 [Gene_View]  chr17:66031848-66042970 [Contig_View]  KPNA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182481 [Gene_View]  chr17:66031848-66042970 [Contig_View]  KPNA2 [Vega]
ICGC DataPortalENSG00000182481
cBioPortalKPNA2
AceView (NCBI)KPNA2
Genatlas (Paris)KPNA2
WikiGenes3838
SOURCE (Princeton)KPNA2
Genomic and cartography
GoldenPath hg19 (UCSC)KPNA2  -     chr17:66031848-66042970 +  17q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)KPNA2  -     17q24.2   [Description]    (hg38-Dec_2013)
EnsemblKPNA2 - 17q24.2 [CytoView hg19]  KPNA2 - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIKPNA2 [Mapview hg19]  KPNA2 [Mapview hg38]
OMIM600685   
Gene and transcription
Genbank (Entrez)AK024833 AK058111 AK291954 BC005978 BC013257
RefSeq transcript (Entrez)NM_002266
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838454 NW_004929407
Consensus coding sequences : CCDS (NCBI)KPNA2
Cluster EST : UnigeneHs.594238 [ NCBI ]
CGAP (NCI)Hs.594238
Alternative Splicing : Fast-db (Paris)GSHG0012756
Alternative Splicing GalleryENSG00000182481
Gene ExpressionKPNA2 [ NCBI-GEO ]     KPNA2 [ SEEK ]   KPNA2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52292 (Uniprot)
NextProtP52292  [Medical]
With graphics : InterProP52292
Splice isoforms : SwissVarP52292 (Swissvar)
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    Importin-a_IBB    Importing_su_alpha   
Related proteins : CluSTrP52292
Domain families : Pfam (Sanger)Arm (PF00514)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM Disease mutations3838
Blocks (Seattle)P52292
PDB (SRS)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
PDB (PDBSum)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
PDB (IMB)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
PDB (RSDB)1EFX    1QGK    1QGR    3FEX    3FEY    4E4V   
Human Protein AtlasENSG00000182481
Peptide AtlasP52292
HPRD02818
IPIIPI00002214   
Protein Interaction databases
DIP (DOE-UCLA)P52292
IntAct (EBI)P52292
FunCoupENSG00000182481
BioGRIDKPNA2
IntegromeDBKPNA2
STRING (EMBL)KPNA2
Ontologies - Pathways
QuickGOP52292
Ontology : AmiGOregulation of DNA recombination  mitotic G2 phase  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  DNA metabolic process  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  viral process  cytokine-mediated signaling pathway  histone deacetylase binding  poly(A) RNA binding  
Ontology : EGO-EBIregulation of DNA recombination  mitotic G2 phase  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  DNA metabolic process  NLS-bearing protein import into nucleus  nuclear localization sequence binding  protein transporter activity  membrane  viral process  cytokine-mediated signaling pathway  histone deacetylase binding  poly(A) RNA binding  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Role of Ran in mitotic spindle regulation [Genes]   
Pathways : KEGGInfluenza A   
Protein Interaction DatabaseKPNA2
DoCM (Curated mutations)KPNA2
Wikipedia pathwaysKPNA2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerKPNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KPNA2
dbVarKPNA2
ClinVarKPNA2
1000_GenomesKPNA2 
Exome Variant ServerKPNA2
SNP (GeneSNP Utah)KPNA2
SNP : HGBaseKPNA2
Genetic variants : HAPMAPKPNA2
Genomic VariantsKPNA2  KPNA2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000182481 
Somatic Mutations in Cancer : COSMICKPNA2 
CONAN: Copy Number AnalysisKPNA2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:66031848-66042970
Mutations and Diseases : HGMDKPNA2
OMIM600685   
MedgenKPNA2
NextProtP52292 [Medical]
GENETestsKPNA2
Disease Genetic AssociationKPNA2
Huge Navigator KPNA2 [HugePedia]  KPNA2 [HugeCancerGEM]
snp3D : Map Gene to Disease3838
DGIdb (Drug Gene Interaction db)KPNA2
General knowledge
Homologs : HomoloGeneKPNA2
Homology/Alignments : Family Browser (UCSC)KPNA2
Phylogenetic Trees/Animal Genes : TreeFamKPNA2
Chemical/Protein Interactions : CTD3838
Chemical/Pharm GKB GenePA30186
Clinical trialKPNA2
Cancer Resource (Charite)ENSG00000182481
Other databases
Probes
Litterature
PubMed230 Pubmed reference(s) in Entrez
CoreMineKPNA2
GoPubMedKPNA2
iHOPKPNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 22:21:06 CET 2014

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