Atlas of Genetics and Cytogenetics in Oncology and Haematology

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KPNA2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1))

Identity

Other namesIPOA1
QIP2
RCH1
SRP1alpha
HGNC (Hugo) KPNA2
LocusID (NCBI) 3838
Location 17q24.2
Location_base_pair Starts at 66031848 and ends at 66042970 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)KPNA2   6395
Entrez_Gene (NCBI)KPNA2  3838  karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Cards
GeneCards (Weizmann)KPNA2
Ensembl (Hinxton)ENSG00000182481 [Gene_View]  chr17:66031848-66042970 [Contig_View]  KPNA2 [Vega]
AceView (NCBI)KPNA2
Genatlas (Paris)KPNA2
SOURCE (Stanford)NM_002266
Genomic and cartography
GoldenPath (UCSC)KPNA2  -  17q24.2   chr17:66031848-66042970 +  17q24.2   [Description]    (hg19-Feb_2009)
EnsemblKPNA2 - 17q24.2 [CytoView]
Mapping of homologs : NCBIKPNA2 [Mapview]
OMIM600685   
Gene and transcription
Genbank (Entrez)AK024833 AK058111 AK291954 BC005978 BC013257
RefSeq transcript (SRS)NM_002266
RefSeq transcript (Entrez)NM_002266
RefSeq genomic (SRS)AC_000149 NC_000017 NT_010783 NW_001838454 NW_003871088 NW_004078739
RefSeq genomic (Entrez)AC_000149 NC_000017 NT_010783 NW_001838454 NW_003871088 NW_004078739
Consensus coding sequences : CCDS (NCBI)KPNA2
Cluster EST : UnigeneHs.594238 [ SRS ] Hs.594238 [ NCBI ]
CGAP (NCI)Hs.594238
Alternative Splicing : Fast-db (Paris)GSHG0012756
Alternative Splicing GalleryENSG00000182481
Gene ExpressionKPNA2 [ NCBI-GEO ]   KPNA2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52292 (SRS) P52292 (Uniprot)
NextProtP52292
With graphics : InterProP52292
Splice isoforms : SwissVarP52292(Swissvar)
Domaine pattern : Prosite (SRS)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)    IBB (PS51214)   
Domains : Interpro (SRS)ARM-like    ARM-type_fold    Armadillo    Importin-a_IBB    Importing_su_alpha   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    Importin-a_IBB    Importing_su_alpha   
Related proteins : CluSTrP52292
Domain families : Pfam (SRS)Arm (PF00514)    IBB (PF01749)   
Domain families : Pfam (Sanger)Arm (PF00514)    IBB (PF01749)   
Domain families : Pfam (NCBI)pfam00514    pfam01749   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM3838
Blocks (Seattle)P52292
PDB (SRS)1EFX    1QGK    1QGR    3FEX    3FEY   
PDB (PDBSum)1EFX    1QGK    1QGR    3FEX    3FEY   
PDB (IMB)1EFX    1QGK    1QGR    3FEX    3FEY   
PDB (RSDB)1EFX    1QGK    1QGR    3FEX    3FEY   
Human Protein AtlasENSG00000182481
HPRD02818
IPIIPI00002214   
Protein Interaction databases
DIP (DOE-UCLA)P52292
IntAct (EBI)P52292
FunCoupENSG00000182481
REACTOMEKPNA2
Protein Interaction Database3838
BioGRIDKPNA2
InParanoidP52292
Interologous Interaction database P52292
IntegromeDBKPNA2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)KPNA2
SNP (GeneSNP Utah)KPNA2
SNP : HGBaseKPNA2
Genetic variants : HAPMAPKPNA2
Somatic Mutations in Cancer : COSMICKPNA2 
CONAN: Copy Number AnalysisKPNA2 
Mutations and Diseases : HGMDKPNA2
OMIM600685   
GENETests600685   
Disease Genetic AssociationKPNA2
Huge Navigator KPNA2 [HugePedia]  KPNA2 [HugeCancerGEM]
Genomic VariantsKPNA2  KPNA2 [DGVbeta]
snp3D : Map Gene to Disease3838
General knowledge
Homologs : HomoloGeneKPNA2
Homology/Alignments : Family Browser (UCSC)KPNA2
Phylogenetic Trees/Animal Genes : TreeFamKPNA2
Chemical/Protein Interactions : CTD3838
Chemical/Pharm GKB GenePA30186
Clinical trialKPNA2
Cancer Resource (Charite)ENSG00000182481
Ontology : AmiGOregulation of DNA recombination  M phase specific microtubule process  G2 phase of mitotic cell cycle  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  DNA metabolic process  NLS-bearing substrate import into nucleus  nuclear localization sequence binding  protein transporter activity  virus-host interaction  cytokine-mediated signaling pathway  histone deacetylase binding  
Ontology : EGO-EBIregulation of DNA recombination  M phase specific microtubule process  G2 phase of mitotic cell cycle  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  DNA metabolic process  NLS-bearing substrate import into nucleus  nuclear localization sequence binding  protein transporter activity  virus-host interaction  cytokine-mediated signaling pathway  histone deacetylase binding  
Pathways : BIOCARTAMechanism of Protein Import into the Nucleus [Genes]    Role of Ran in mitotic spindle regulation [Genes]   
Other databases
Probes
Litterature
PubMed201 Pubmed reference(s) in Entrez
PubGeneKPNA2
iHOPKPNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:27:59 CEST 2013
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