KRT16 (keratin 16)

2008-05-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
CK16,FNEPPK,K16,K1CP,KRT16A,NEPPK,PC1

Other Information

Locus ID:

NCBI: 3868
MIM: 148067
HGNC: 6423
Ensembl: ENSG00000186832

Variants:

dbSNP: 3868
ClinVar: 3868
TCGA: ENSG00000186832
COSMIC: KRT16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186832ENST00000301653P08779
ENSG00000186832ENST00000590990K7ENV3
ENSG00000186832ENST00000593067K7ENW6

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235498732013Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer.53
242185832013Keratin 16 regulates innate immunity in response to epidermal barrier breach.47
176236752007ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.28
129546312003Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun.20
222646702012A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.15
285767372017Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17.15
207223892010Trichohyalin is a potential major autoantigen in human alopecia areata.11
211604962011Genotype-phenotype correlations among pachyonychia congenita patients with K16 mutations.11
177197472007A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.7
281282032017Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16.7

Citation

Dessen P

KRT16 (keratin 16)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50129/krt16