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LAT2 (linker for activation of T-cells family member 2)

Identity

Alias_namesWBSCR15
WBSCR5
Williams-Beuren syndrome chromosome region 5
linker for activation of T cells family, member 2
Alias_symbol (synonym)WSCR5
HSPC046
LAB
NTAL
Other alias
HGNC (Hugo) LAT2
LocusID (NCBI) 7462
Atlas_Id 51310
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 73624087 and ends at 73644164 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LAT2 (7q11.23) / CDC25C (5q31.2)PDE1C (7p14.3) / LAT2 (7q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LAT2   12749
Cards
Entrez_Gene (NCBI)LAT2  7462  linker for activation of T-cells family member 2
AliasesHSPC046; LAB; NTAL; WBSCR15; 
WBSCR5; WSCR5
GeneCards (Weizmann)LAT2
Ensembl hg19 (Hinxton)ENSG00000086730 [Gene_View]  chr7:73624087-73644164 [Contig_View]  LAT2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000086730 [Gene_View]  chr7:73624087-73644164 [Contig_View]  LAT2 [Vega]
ICGC DataPortalENSG00000086730
TCGA cBioPortalLAT2
AceView (NCBI)LAT2
Genatlas (Paris)LAT2
WikiGenes7462
SOURCE (Princeton)LAT2
Genetics Home Reference (NIH)LAT2
Genomic and cartography
GoldenPath hg19 (UCSC)LAT2  -     chr7:73624087-73644164 +  7q11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LAT2  -     7q11.23   [Description]    (hg38-Dec_2013)
EnsemblLAT2 - 7q11.23 [CytoView hg19]  LAT2 - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBILAT2 [Mapview hg19]  LAT2 [Mapview hg38]
OMIM605719   
Gene and transcription
Genbank (Entrez)AF086239 AF161531 AF252611 AF252612 AF252613
RefSeq transcript (Entrez)NM_014146 NM_032463 NM_032464
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_023256 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LAT2
Cluster EST : UnigeneHs.741249 [ NCBI ]
CGAP (NCI)Hs.741249
Alternative Splicing GalleryENSG00000086730
Gene ExpressionLAT2 [ NCBI-GEO ]   LAT2 [ EBI - ARRAY_EXPRESS ]   LAT2 [ SEEK ]   LAT2 [ MEM ]
Gene Expression Viewer (FireBrowse)LAT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7462
GTEX Portal (Tissue expression)LAT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZY6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZY6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZY6
Splice isoforms : SwissVarQ9GZY6
PhosPhoSitePlusQ9GZY6
Domains : Interpro (EBI)LAT2   
Domain families : Pfam (Sanger)LAT2 (PF15703)   
Domain families : Pfam (NCBI)pfam15703   
Domain structure : Prodom (Prabi Lyon)PD332876 (PD332876)   
Conserved Domain (NCBI)LAT2
DMDM Disease mutations7462
Blocks (Seattle)LAT2
PDB (SRS)3MAZ   
PDB (PDBSum)3MAZ   
PDB (IMB)3MAZ   
PDB (RSDB)3MAZ   
Structural Biology KnowledgeBase3MAZ   
SCOP (Structural Classification of Proteins)3MAZ   
CATH (Classification of proteins structures)3MAZ   
SuperfamilyQ9GZY6
Human Protein AtlasENSG00000086730
Peptide AtlasQ9GZY6
HPRD09304
IPIIPI00395993   IPI00032447   IPI00793559   IPI01010939   IPI00976661   IPI00945042   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZY6
IntAct (EBI)Q9GZY6
FunCoupENSG00000086730
BioGRIDLAT2
STRING (EMBL)LAT2
ZODIACLAT2
Ontologies - Pathways
QuickGOQ9GZY6
Ontology : AmiGOadaptive immune response  protein binding  intracellular  plasma membrane  integral component of membrane  calcium-mediated signaling  intracellular signal transduction  Fc-epsilon receptor signaling pathway  B cell activation  B cell activation  SH2 domain binding  SH2 domain binding  mast cell granule  mast cell degranulation  membrane raft  B cell receptor signaling pathway  extracellular exosome  
Ontology : EGO-EBIadaptive immune response  protein binding  intracellular  plasma membrane  integral component of membrane  calcium-mediated signaling  intracellular signal transduction  Fc-epsilon receptor signaling pathway  B cell activation  B cell activation  SH2 domain binding  SH2 domain binding  mast cell granule  mast cell degranulation  membrane raft  B cell receptor signaling pathway  extracellular exosome  
NDEx NetworkLAT2
Atlas of Cancer Signalling NetworkLAT2
Wikipedia pathwaysLAT2
Orthology - Evolution
OrthoDB7462
GeneTree (enSembl)ENSG00000086730
Phylogenetic Trees/Animal Genes : TreeFamLAT2
HOVERGENQ9GZY6
HOGENOMQ9GZY6
Homologs : HomoloGeneLAT2
Homology/Alignments : Family Browser (UCSC)LAT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAT2
dbVarLAT2
ClinVarLAT2
1000_GenomesLAT2 
Exome Variant ServerLAT2
ExAC (Exome Aggregation Consortium)LAT2 (select the gene name)
Genetic variants : HAPMAP7462
Genomic Variants (DGV)LAT2 [DGVbeta]
DECIPHER (Syndromes)7:73624087-73644164  ENSG00000086730
CONAN: Copy Number AnalysisLAT2 
Mutations
ICGC Data PortalLAT2 
TCGA Data PortalLAT2 
Broad Tumor PortalLAT2
OASIS PortalLAT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLAT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAT2
DgiDB (Drug Gene Interaction Database)LAT2
DoCM (Curated mutations)LAT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAT2 (select a term)
intoGenLAT2
Cancer3DLAT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605719   
Orphanet
MedgenLAT2
Genetic Testing Registry LAT2
NextProtQ9GZY6 [Medical]
TSGene7462
GENETestsLAT2
Huge Navigator LAT2 [HugePedia]
snp3D : Map Gene to Disease7462
BioCentury BCIQLAT2
ClinGenLAT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7462
Chemical/Pharm GKB GenePA37356
Clinical trialLAT2
Miscellaneous
canSAR (ICR)LAT2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAT2
EVEXLAT2
GoPubMedLAT2
iHOPLAT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:31 CET 2017

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