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LCT (lactase)

Identity

Other namesLAC
LPH
LPH1
HGNC (Hugo) LCT
LocusID (NCBI) 3938
Location 2q21.3
Location_base_pair Starts at 136545415 and ends at 136594750 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LCT   6530
Cards
Entrez_Gene (NCBI)LCT  3938  lactase
GeneCards (Weizmann)LCT
Ensembl (Hinxton)ENSG00000115850 [Gene_View]  chr2:136545415-136594750 [Contig_View]  LCT [Vega]
ICGC DataPortalENSG00000115850
cBioPortalLCT
AceView (NCBI)LCT
Genatlas (Paris)LCT
WikiGenes3938
SOURCE (Princeton)NM_002299
Genomic and cartography
GoldenPath (UCSC)LCT  -  2q21.3   chr2:136545415-136594750 -  2q21.3   [Description]    (hg19-Feb_2009)
EnsemblLCT - 2q21.3 [CytoView]
Mapping of homologs : NCBILCT [Mapview]
OMIM223000   603202   
Gene and transcription
Genbank (Entrez)BC156075 BC156950 X07994
RefSeq transcript (Entrez)NM_002299
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008104 NT_005403 NW_001838859 NW_004929304
Consensus coding sequences : CCDS (NCBI)LCT
Cluster EST : UnigeneHs.551506 [ NCBI ]
CGAP (NCI)Hs.551506
Alternative Splicing : Fast-db (Paris)GSHG0018031
Alternative Splicing GalleryENSG00000115850
Gene ExpressionLCT [ NCBI-GEO ]     LCT [ SEEK ]   LCT [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09848 (Uniprot)
NextProtP09848  [Medical]
With graphics : InterProP09848
Splice isoforms : SwissVarP09848 (Swissvar)
Catalytic activity : Enzyme3.2.1.108 [ Enzyme-Expasy ]   3.2.1.1083.2.1.108 [ IntEnz-EBI ]   3.2.1.108 [ BRENDA ]   3.2.1.108 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GLYCOSYL_HYDROL_F1_1 (PS00572)    GLYCOSYL_HYDROL_F1_2 (PS00653)   
Domains : Interpro (EBI)Glyco_hydro_1 [organisation]   Glyco_hydro_1_AS [organisation]   Glyco_hydro_catalytic_dom [organisation]   Glycoside_hydrolase_SF [organisation]  
Related proteins : CluSTrP09848
Domain families : Pfam (Sanger)Glyco_hydro_1 (PF00232)   
Domain families : Pfam (NCBI)pfam00232   
DMDM Disease mutations3938
Blocks (Seattle)P09848
Human Protein AtlasENSG00000115850 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP09848
HPRD04437
IPIIPI00017648   IPI00930743   IPI00916950   
Protein Interaction databases
DIP (DOE-UCLA)P09848
IntAct (EBI)P09848
FunCoupENSG00000115850
BioGRIDLCT
InParanoidP09848
Interologous Interaction database P09848
IntegromeDBLCT
STRING (EMBL)LCT
Ontologies - Pathways
Ontology : AmiGOlactase activity  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  membrane  apical plasma membrane  glycosylceramidase activity  polysaccharide digestion  small molecule metabolic process  
Ontology : EGO-EBIlactase activity  plasma membrane  integral component of plasma membrane  carbohydrate metabolic process  membrane  apical plasma membrane  glycosylceramidase activity  polysaccharide digestion  small molecule metabolic process  
Pathways : KEGGGalactose metabolism    Carbohydrate digestion and absorption   
Protein Interaction DatabaseLCT
Wikipedia pathwaysLCT
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LCT
snp3D : Map Gene to Disease3938
SNP (GeneSNP Utah)LCT
SNP : HGBaseLCT
Genetic variants : HAPMAPLCT
Exome VariantLCT
1000_GenomesLCT 
ICGC programENSG00000115850 
Somatic Mutations in Cancer : COSMICLCT 
CONAN: Copy Number AnalysisLCT 
Mutations and Diseases : HGMDLCT
Mutations and Diseases : intOGenLCT
Genomic VariantsLCT  LCT [DGVbeta]
dbVarLCT
ClinVarLCT
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM223000    603202   
MedgenLCT
GENETestsLCT
Disease Genetic AssociationLCT
Huge Navigator LCT [HugePedia]  LCT [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneLCT
Homology/Alignments : Family Browser (UCSC)LCT
Phylogenetic Trees/Animal Genes : TreeFamLCT
Chemical/Protein Interactions : CTD3938
Chemical/Pharm GKB GenePA30315
Clinical trialLCT
Cancer Resource (Charite)ENSG00000115850
Other databases
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
CoreMineLCT
iHOPLCT
OncoSearchLCT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:52:30 CEST 2014

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