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LEFTY1 (left-right determination factor 1)

Identity

Alias_namesLEFTB
left-right determination
Alias_symbol (synonym)LEFTYB
Other alias
HGNC (Hugo) LEFTY1
LocusID (NCBI) 10637
Atlas_Id 41138
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 226073982 and ends at 226076846 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LEFTY1 (1q42.12) / INS-IGF2 (11p15.5)LEFTY1 (1q42.12) / TNNI1 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LEFTY1   6552
Cards
Entrez_Gene (NCBI)LEFTY1  10637  left-right determination factor 1
AliasesLEFTB; LEFTYB
GeneCards (Weizmann)LEFTY1
Ensembl hg19 (Hinxton)ENSG00000243709 [Gene_View]  chr1:226073982-226076846 [Contig_View]  LEFTY1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000243709 [Gene_View]  chr1:226073982-226076846 [Contig_View]  LEFTY1 [Vega]
ICGC DataPortalENSG00000243709
TCGA cBioPortalLEFTY1
AceView (NCBI)LEFTY1
Genatlas (Paris)LEFTY1
WikiGenes10637
SOURCE (Princeton)LEFTY1
Genetics Home Reference (NIH)LEFTY1
Genomic and cartography
GoldenPath hg19 (UCSC)LEFTY1  -     chr1:226073982-226076846 -  1q42.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LEFTY1  -     1q42.12   [Description]    (hg38-Dec_2013)
EnsemblLEFTY1 - 1q42.12 [CytoView hg19]  LEFTY1 - 1q42.12 [CytoView hg38]
Mapping of homologs : NCBILEFTY1 [Mapview hg19]  LEFTY1 [Mapview hg38]
OMIM603037   
Gene and transcription
Genbank (Entrez)AF081512 AK129605 AK222714 AK309263 AK313115
RefSeq transcript (Entrez)NM_020997
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)LEFTY1
Cluster EST : UnigeneHs.656214 [ NCBI ]
CGAP (NCI)Hs.656214
Alternative Splicing GalleryENSG00000243709
Gene ExpressionLEFTY1 [ NCBI-GEO ]   LEFTY1 [ EBI - ARRAY_EXPRESS ]   LEFTY1 [ SEEK ]   LEFTY1 [ MEM ]
Gene Expression Viewer (FireBrowse)LEFTY1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10637
GTEX Portal (Tissue expression)LEFTY1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75610   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75610  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75610
Splice isoforms : SwissVarO75610
PhosPhoSitePlusO75610
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    LRDF    TGF-b_C    TGF-b_N    TGF-beta-rel    TGFb_CS   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
Conserved Domain (NCBI)LEFTY1
DMDM Disease mutations10637
Blocks (Seattle)LEFTY1
SuperfamilyO75610
Human Protein AtlasENSG00000243709
Peptide AtlasO75610
HPRD09116
IPIIPI00604473   IPI00930554   
Protein Interaction databases
DIP (DOE-UCLA)O75610
IntAct (EBI)O75610
FunCoupENSG00000243709
BioGRIDLEFTY1
STRING (EMBL)LEFTY1
ZODIACLEFTY1
Ontologies - Pathways
QuickGOO75610
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  heart morphogenesis  cytokine activity  transforming growth factor beta receptor binding  extracellular space  transforming growth factor beta receptor signaling pathway  determination of left/right symmetry  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  cell growth  regulation of apoptotic process  regulation of MAPK cascade  cell development  SMAD protein signal transduction  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  heart morphogenesis  cytokine activity  transforming growth factor beta receptor binding  extracellular space  transforming growth factor beta receptor signaling pathway  determination of left/right symmetry  growth factor activity  positive regulation of pathway-restricted SMAD protein phosphorylation  cell growth  regulation of apoptotic process  regulation of MAPK cascade  cell development  SMAD protein signal transduction  
Pathways : KEGGTGF-beta signaling pathway   
NDEx NetworkLEFTY1
Atlas of Cancer Signalling NetworkLEFTY1
Wikipedia pathwaysLEFTY1
Orthology - Evolution
OrthoDB10637
GeneTree (enSembl)ENSG00000243709
Phylogenetic Trees/Animal Genes : TreeFamLEFTY1
HOVERGENO75610
HOGENOMO75610
Homologs : HomoloGeneLEFTY1
Homology/Alignments : Family Browser (UCSC)LEFTY1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEFTY1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEFTY1
dbVarLEFTY1
ClinVarLEFTY1
1000_GenomesLEFTY1 
Exome Variant ServerLEFTY1
ExAC (Exome Aggregation Consortium)LEFTY1 (select the gene name)
Genetic variants : HAPMAP10637
Genomic Variants (DGV)LEFTY1 [DGVbeta]
DECIPHER (Syndromes)1:226073982-226076846  ENSG00000243709
CONAN: Copy Number AnalysisLEFTY1 
Mutations
ICGC Data PortalLEFTY1 
TCGA Data PortalLEFTY1 
Broad Tumor PortalLEFTY1
OASIS PortalLEFTY1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEFTY1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLEFTY1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEFTY1
DgiDB (Drug Gene Interaction Database)LEFTY1
DoCM (Curated mutations)LEFTY1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEFTY1 (select a term)
intoGenLEFTY1
Cancer3DLEFTY1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603037   
Orphanet
MedgenLEFTY1
Genetic Testing Registry LEFTY1
NextProtO75610 [Medical]
TSGene10637
GENETestsLEFTY1
Huge Navigator LEFTY1 [HugePedia]
snp3D : Map Gene to Disease10637
BioCentury BCIQLEFTY1
ClinGenLEFTY1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10637
Chemical/Pharm GKB GenePA30332
Clinical trialLEFTY1
Miscellaneous
canSAR (ICR)LEFTY1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEFTY1
EVEXLEFTY1
GoPubMedLEFTY1
iHOPLEFTY1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:39 CET 2017

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