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LEMD1 (LEM domain containing 1)

Identity

Alias_symbol (synonym)LEMP-1
CT50
Other alias
HGNC (Hugo) LEMD1
LocusID (NCBI) 93273
Atlas_Id 46546
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205381379 and ends at 205422086 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUAK2 (1q32.1) / LEMD1 (1q32.1)NUAK2 1q32.1 / LEMD1 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q32;q32) NUAK2/LEMD1

External links

Nomenclature
HGNC (Hugo)LEMD1   18725
Cards
Entrez_Gene (NCBI)LEMD1  93273  LEM domain containing 1
AliasesCT50; LEMP-1
GeneCards (Weizmann)LEMD1
Ensembl hg19 (Hinxton)ENSG00000186007 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186007 [Gene_View]  ENSG00000186007 [Sequence]  chr1:205381379-205422086 [Contig_View]  LEMD1 [Vega]
ICGC DataPortalENSG00000186007
TCGA cBioPortalLEMD1
AceView (NCBI)LEMD1
Genatlas (Paris)LEMD1
WikiGenes93273
SOURCE (Princeton)LEMD1
Genetics Home Reference (NIH)LEMD1
Genomic and cartography
GoldenPath hg38 (UCSC)LEMD1  -     chr1:205381379-205422086 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LEMD1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblLEMD1 - 1q32.1 [CytoView hg19]  LEMD1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBILEMD1 [Mapview hg19]  LEMD1 [Mapview hg38]
OMIM610480   
Gene and transcription
Genbank (Entrez)AB084764 AB084765 AB085610 AB096677 AB096678
RefSeq transcript (Entrez)NM_001001552 NM_001199050 NM_001199051 NM_001199052
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LEMD1
Cluster EST : UnigeneHs.745447 [ NCBI ]
CGAP (NCI)Hs.745447
Alternative Splicing GalleryENSG00000186007
Gene ExpressionLEMD1 [ NCBI-GEO ]   LEMD1 [ EBI - ARRAY_EXPRESS ]   LEMD1 [ SEEK ]   LEMD1 [ MEM ]
Gene Expression Viewer (FireBrowse)LEMD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93273
GTEX Portal (Tissue expression)LEMD1
Human Protein AtlasENSG00000186007-LEMD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68G75   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ68G75  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68G75
Splice isoforms : SwissVarQ68G75
PhosPhoSitePlusQ68G75
Domaine pattern : Prosite (Expaxy)LEM (PS50954)   
Domains : Interpro (EBI)LEM/LEM-like_dom    LEM_dom   
Domain families : Pfam (Sanger)LEM (PF03020)   
Domain families : Pfam (NCBI)pfam03020   
Domain families : Smart (EMBL)LEM (SM00540)  
Conserved Domain (NCBI)LEMD1
DMDM Disease mutations93273
Blocks (Seattle)LEMD1
SuperfamilyQ68G75
Human Protein Atlas [tissue]ENSG00000186007-LEMD1 [tissue]
Peptide AtlasQ68G75
HPRD13983
IPIIPI00470356   IPI00845344   IPI00438351   IPI00845301   IPI00642166   IPI00843993   
Protein Interaction databases
DIP (DOE-UCLA)Q68G75
IntAct (EBI)Q68G75
FunCoupENSG00000186007
BioGRIDLEMD1
STRING (EMBL)LEMD1
ZODIACLEMD1
Ontologies - Pathways
QuickGOQ68G75
Ontology : AmiGOintegral component of membrane  
Ontology : EGO-EBIintegral component of membrane  
NDEx NetworkLEMD1
Atlas of Cancer Signalling NetworkLEMD1
Wikipedia pathwaysLEMD1
Orthology - Evolution
OrthoDB93273
GeneTree (enSembl)ENSG00000186007
Phylogenetic Trees/Animal Genes : TreeFamLEMD1
HOVERGENQ68G75
HOGENOMQ68G75
Homologs : HomoloGeneLEMD1
Homology/Alignments : Family Browser (UCSC)LEMD1
Gene fusions - Rearrangements
Fusion : MitelmanNUAK2/LEMD1 [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion PortalNUAK2 1q32.1 LEMD1 1q32.1 HNSC
Fusion : QuiverLEMD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLEMD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LEMD1
dbVarLEMD1
ClinVarLEMD1
1000_GenomesLEMD1 
Exome Variant ServerLEMD1
ExAC (Exome Aggregation Consortium)ENSG00000186007
GNOMAD BrowserENSG00000186007
Genetic variants : HAPMAP93273
Genomic Variants (DGV)LEMD1 [DGVbeta]
DECIPHERLEMD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLEMD1 
Mutations
ICGC Data PortalLEMD1 
TCGA Data PortalLEMD1 
Broad Tumor PortalLEMD1
OASIS PortalLEMD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLEMD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLEMD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LEMD1
DgiDB (Drug Gene Interaction Database)LEMD1
DoCM (Curated mutations)LEMD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LEMD1 (select a term)
intoGenLEMD1
Cancer3DLEMD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610480   
Orphanet
DisGeNETLEMD1
MedgenLEMD1
Genetic Testing Registry LEMD1
NextProtQ68G75 [Medical]
TSGene93273
GENETestsLEMD1
Target ValidationLEMD1
Huge Navigator LEMD1 [HugePedia]
snp3D : Map Gene to Disease93273
BioCentury BCIQLEMD1
ClinGenLEMD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD93273
Chemical/Pharm GKB GenePA38660
Clinical trialLEMD1
Miscellaneous
canSAR (ICR)LEMD1 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLEMD1
EVEXLEMD1
GoPubMedLEMD1
iHOPLEMD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jun 22 16:32:59 CEST 2018
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