LIMS2 (LIM zinc finger domain containing 2)

2007-02-01  

Identity

HGNC
LIMS2
LOCATION
2q14.3
LOCUSID
55679
ALIAS
LGMD2W,MDRCMTT,PINCH-2,PINCH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55679
MIM: 607908
HGNC: 16084
Ensembl: ENSG00000072163

Variants:

dbSNP: 55679
ClinVar: 55679
TCGA: ENSG00000072163
COSMIC: LIMS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072163ENST00000324938Q7Z4I7
ENSG00000072163ENST00000355119Q7Z4I7
ENSG00000072163ENST00000409254Q7Z4I7
ENSG00000072163ENST00000409286Q7Z4I7
ENSG00000072163ENST00000409455Q7Z4I7
ENSG00000072163ENST00000409455A0A024RAH1
ENSG00000072163ENST00000409754Q7Z4I7
ENSG00000072163ENST00000409808Q7Z4I7
ENSG00000072163ENST00000409808A0A024RAH1
ENSG00000072163ENST00000410011Q7Z4I7
ENSG00000072163ENST00000410011A0A024RAH1
ENSG00000072163ENST00000410038Q7Z4I7
ENSG00000072163ENST00000413578F8WEF3
ENSG00000072163ENST00000426981H0Y592
ENSG00000072163ENST00000545738Q7Z4I7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-extracellular matrix interactionsREACTOMER-HSA-446353

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
121676432002Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.38
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
169592132006The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration.14
253460442015PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity.4
255892442015LIMS2 mutations are associated with a novel muscular dystrophy, severe cardiomyopathy and triangular tongues.4
275904402016Signaling via PINCH: Functions, binding partners and implications in human diseases.4
205005202011PINCH-2 expression in cancers involving serosal effusions using quantitative PCR.1

Citation

Dessen P

LIMS2 (LIM zinc finger domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46170/lims2