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LIN28A (lin-28 homolog A)

Identity

Alias_namesLIN28
lin-28 homolog (C. elegans)
Alias_symbol (synonym)LIN-28
FLJ12457
ZCCHC1
CSDD1
Other aliaslin-28A
HGNC (Hugo) LIN28A
LocusID (NCBI) 79727
Atlas_Id 51415
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26737259 and ends at 26756219 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EIF4G3 (1p36.12) / LIN28A (1p36.11)RPS6KA1 (1p36.11) / LIN28A (1p36.11)EIF4G3 1p36.12 / LIN28A 1p36.11
RPS6KA1 1p36.11 / LIN28A 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LIN28A   15986
Cards
Entrez_Gene (NCBI)LIN28A  79727  lin-28 homolog A
AliasesCSDD1; LIN-28; LIN28; ZCCHC1; 
lin-28A
GeneCards (Weizmann)LIN28A
Ensembl hg19 (Hinxton)ENSG00000131914 [Gene_View]  chr1:26737259-26756219 [Contig_View]  LIN28A [Vega]
Ensembl hg38 (Hinxton)ENSG00000131914 [Gene_View]  chr1:26737259-26756219 [Contig_View]  LIN28A [Vega]
ICGC DataPortalENSG00000131914
TCGA cBioPortalLIN28A
AceView (NCBI)LIN28A
Genatlas (Paris)LIN28A
WikiGenes79727
SOURCE (Princeton)LIN28A
Genetics Home Reference (NIH)LIN28A
Genomic and cartography
GoldenPath hg19 (UCSC)LIN28A  -     chr1:26737259-26756219 +  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LIN28A  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblLIN28A - 1p36.11 [CytoView hg19]  LIN28A - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBILIN28A [Mapview hg19]  LIN28A [Mapview hg38]
OMIM611043   
Gene and transcription
Genbank (Entrez)AF521099 AK022519 BC028566 CN349325 DQ893398
RefSeq transcript (Entrez)NM_024674
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)LIN28A
Cluster EST : UnigeneHs.86154 [ NCBI ]
CGAP (NCI)Hs.86154
Alternative Splicing GalleryENSG00000131914
Gene ExpressionLIN28A [ NCBI-GEO ]   LIN28A [ EBI - ARRAY_EXPRESS ]   LIN28A [ SEEK ]   LIN28A [ MEM ]
Gene Expression Viewer (FireBrowse)LIN28A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79727
GTEX Portal (Tissue expression)LIN28A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9Z2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9Z2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9Z2
Splice isoforms : SwissVarQ9H9Z2
PhosPhoSitePlusQ9H9Z2
Domaine pattern : Prosite (Expaxy)ZF_CCHC (PS50158)   
Domains : Interpro (EBI)Cold_shock_prot    CSP_DNA-bd    NA-bd_OB-fold    Znf_CCHC   
Domain families : Pfam (Sanger)CSD (PF00313)    zf-CCHC (PF00098)   
Domain families : Pfam (NCBI)pfam00313    pfam00098   
Domain families : Smart (EMBL)CSP (SM00357)  ZnF_C2HC (SM00343)  
Conserved Domain (NCBI)LIN28A
DMDM Disease mutations79727
Blocks (Seattle)LIN28A
PDB (SRS)2CQF    2LI8   
PDB (PDBSum)2CQF    2LI8   
PDB (IMB)2CQF    2LI8   
PDB (RSDB)2CQF    2LI8   
Structural Biology KnowledgeBase2CQF    2LI8   
SCOP (Structural Classification of Proteins)2CQF    2LI8   
CATH (Classification of proteins structures)2CQF    2LI8   
SuperfamilyQ9H9Z2
Human Protein AtlasENSG00000131914
Peptide AtlasQ9H9Z2
HPRD17278
IPIIPI00002948   
Protein Interaction databases
DIP (DOE-UCLA)Q9H9Z2
IntAct (EBI)Q9H9Z2
FunCoupENSG00000131914
BioGRIDLIN28A
STRING (EMBL)LIN28A
ZODIACLIN28A
Ontologies - Pathways
QuickGOQ9H9Z2
Ontology : AmiGOcytoplasmic mRNA processing body  DNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleolus  cytoplasm  cytosol  regulation of transcription, DNA-templated  germ cell development  zinc ion binding  cytoplasmic stress granule  miRNA catabolic process  stem cell population maintenance  pre-miRNA processing  RNA 3'-end processing  translation initiation factor binding  somatic stem cell population maintenance  miRNA binding  positive regulation of neuron differentiation  negative regulation of glial cell differentiation  positive regulation of translation  stem cell differentiation  regulation of gene silencing by miRNA  positive regulation of cell proliferation involved in kidney development  
Ontology : EGO-EBIcytoplasmic mRNA processing body  DNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleolus  cytoplasm  cytosol  regulation of transcription, DNA-templated  germ cell development  zinc ion binding  cytoplasmic stress granule  miRNA catabolic process  stem cell population maintenance  pre-miRNA processing  RNA 3'-end processing  translation initiation factor binding  somatic stem cell population maintenance  miRNA binding  positive regulation of neuron differentiation  negative regulation of glial cell differentiation  positive regulation of translation  stem cell differentiation  regulation of gene silencing by miRNA  positive regulation of cell proliferation involved in kidney development  
NDEx NetworkLIN28A
Atlas of Cancer Signalling NetworkLIN28A
Wikipedia pathwaysLIN28A
Orthology - Evolution
OrthoDB79727
GeneTree (enSembl)ENSG00000131914
Phylogenetic Trees/Animal Genes : TreeFamLIN28A
HOVERGENQ9H9Z2
HOGENOMQ9H9Z2
Homologs : HomoloGeneLIN28A
Homology/Alignments : Family Browser (UCSC)LIN28A
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G3/LIN28A [1p36.12/1p36.11]  [t(1;1)(p36;p36)]  
Fusion : MitelmanRPS6KA1/LIN28A [1p36.11/1p36.11]  [t(1;1)(p36;p36)]  
Fusion: TCGAEIF4G3 1p36.12 LIN28A 1p36.11 HNSC
Fusion: TCGARPS6KA1 1p36.11 LIN28A 1p36.11 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLIN28A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LIN28A
dbVarLIN28A
ClinVarLIN28A
1000_GenomesLIN28A 
Exome Variant ServerLIN28A
ExAC (Exome Aggregation Consortium)LIN28A (select the gene name)
Genetic variants : HAPMAP79727
Genomic Variants (DGV)LIN28A [DGVbeta]
DECIPHER (Syndromes)1:26737259-26756219  ENSG00000131914
CONAN: Copy Number AnalysisLIN28A 
Mutations
ICGC Data PortalLIN28A 
TCGA Data PortalLIN28A 
Broad Tumor PortalLIN28A
OASIS PortalLIN28A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLIN28A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLIN28A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LIN28A
DgiDB (Drug Gene Interaction Database)LIN28A
DoCM (Curated mutations)LIN28A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LIN28A (select a term)
intoGenLIN28A
Cancer3DLIN28A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611043   
Orphanet
MedgenLIN28A
Genetic Testing Registry LIN28A
NextProtQ9H9Z2 [Medical]
TSGene79727
GENETestsLIN28A
Huge Navigator LIN28A [HugePedia]
snp3D : Map Gene to Disease79727
BioCentury BCIQLIN28A
ClinGenLIN28A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79727
Chemical/Pharm GKB GenePA165751523
Clinical trialLIN28A
Miscellaneous
canSAR (ICR)LIN28A (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLIN28A
EVEXLIN28A
GoPubMedLIN28A
iHOPLIN28A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:12:51 CET 2017

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