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LMTK2 (lemur tyrosine kinase 2)

Identity

Alias_namesregulatory subunit 100
Alias_symbol (synonym)KIAA1079
KPI2
KPI-2
cprk
LMR2
BREK
AATYK2
PPP1R100
Other aliashBREK
HGNC (Hugo) LMTK2
LocusID (NCBI) 22853
Atlas_Id 43337
Location 7q21.3  [Link to chromosome band 7q21]
Location_base_pair Starts at 97736197 and ends at 97838944 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BVES (6q21) / LMTK2 (7q21.3)NDRG3 (20q11.23) / LMTK2 (7q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LMTK2   17880
Cards
Entrez_Gene (NCBI)LMTK2  22853  lemur tyrosine kinase 2
AliasesAATYK2; BREK; KPI-2; KPI2; 
LMR2; PPP1R100; cprk; hBREK
GeneCards (Weizmann)LMTK2
Ensembl hg19 (Hinxton)ENSG00000164715 [Gene_View]  chr7:97736197-97838944 [Contig_View]  LMTK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164715 [Gene_View]  chr7:97736197-97838944 [Contig_View]  LMTK2 [Vega]
ICGC DataPortalENSG00000164715
TCGA cBioPortalLMTK2
AceView (NCBI)LMTK2
Genatlas (Paris)LMTK2
WikiGenes22853
SOURCE (Princeton)LMTK2
Genetics Home Reference (NIH)LMTK2
Genomic and cartography
GoldenPath hg19 (UCSC)LMTK2  -     chr7:97736197-97838944 +  7q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)LMTK2  -     7q21.3   [Description]    (hg38-Dec_2013)
EnsemblLMTK2 - 7q21.3 [CytoView hg19]  LMTK2 - 7q21.3 [CytoView hg38]
Mapping of homologs : NCBILMTK2 [Mapview hg19]  LMTK2 [Mapview hg38]
OMIM610989   
Gene and transcription
Genbank (Entrez)AB029002 AK128506 AW183515 AY130988 BC080576
RefSeq transcript (Entrez)NM_014916
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_013375 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)LMTK2
Cluster EST : UnigeneHs.444179 [ NCBI ]
CGAP (NCI)Hs.444179
Alternative Splicing GalleryENSG00000164715
Gene ExpressionLMTK2 [ NCBI-GEO ]   LMTK2 [ EBI - ARRAY_EXPRESS ]   LMTK2 [ SEEK ]   LMTK2 [ MEM ]
Gene Expression Viewer (FireBrowse)LMTK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22853
GTEX Portal (Tissue expression)LMTK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWU2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWU2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWU2
Splice isoforms : SwissVarQ8IWU2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8IWU2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)LMTK2
DMDM Disease mutations22853
Blocks (Seattle)LMTK2
SuperfamilyQ8IWU2
Human Protein AtlasENSG00000164715
Peptide AtlasQ8IWU2
HPRD13994
IPIIPI00217391   IPI00978661   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWU2
IntAct (EBI)Q8IWU2
FunCoupENSG00000164715
BioGRIDLMTK2
STRING (EMBL)LMTK2
ZODIACLMTK2
Ontologies - Pathways
QuickGOQ8IWU2
Ontology : AmiGOreceptor recycling  protein serine/threonine kinase activity  protein phosphatase inhibitor activity  protein binding  ATP binding  early endosome  Golgi apparatus  cytosol  protein phosphorylation  integral component of membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  endocytic recycling  transferrin transport  negative regulation of catalytic activity  early endosome to late endosome transport  protein autophosphorylation  perinuclear region of cytoplasm  recycling endosome  myosin VI binding  
Ontology : EGO-EBIreceptor recycling  protein serine/threonine kinase activity  protein phosphatase inhibitor activity  protein binding  ATP binding  early endosome  Golgi apparatus  cytosol  protein phosphorylation  integral component of membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  endocytic recycling  transferrin transport  negative regulation of catalytic activity  early endosome to late endosome transport  protein autophosphorylation  perinuclear region of cytoplasm  recycling endosome  myosin VI binding  
NDEx NetworkLMTK2
Atlas of Cancer Signalling NetworkLMTK2
Wikipedia pathwaysLMTK2
Orthology - Evolution
OrthoDB22853
GeneTree (enSembl)ENSG00000164715
Phylogenetic Trees/Animal Genes : TreeFamLMTK2
HOVERGENQ8IWU2
HOGENOMQ8IWU2
Homologs : HomoloGeneLMTK2
Homology/Alignments : Family Browser (UCSC)LMTK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLMTK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LMTK2
dbVarLMTK2
ClinVarLMTK2
1000_GenomesLMTK2 
Exome Variant ServerLMTK2
ExAC (Exome Aggregation Consortium)LMTK2 (select the gene name)
Genetic variants : HAPMAP22853
Genomic Variants (DGV)LMTK2 [DGVbeta]
DECIPHER (Syndromes)7:97736197-97838944  ENSG00000164715
CONAN: Copy Number AnalysisLMTK2 
Mutations
ICGC Data PortalLMTK2 
TCGA Data PortalLMTK2 
Broad Tumor PortalLMTK2
OASIS PortalLMTK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLMTK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLMTK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LMTK2
DgiDB (Drug Gene Interaction Database)LMTK2
DoCM (Curated mutations)LMTK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LMTK2 (select a term)
intoGenLMTK2
Cancer3DLMTK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610989   
Orphanet
MedgenLMTK2
Genetic Testing Registry LMTK2
NextProtQ8IWU2 [Medical]
TSGene22853
GENETestsLMTK2
Huge Navigator LMTK2 [HugePedia]
snp3D : Map Gene to Disease22853
BioCentury BCIQLMTK2
ClinGenLMTK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22853
Chemical/Pharm GKB GenePA134884391
Clinical trialLMTK2
Miscellaneous
canSAR (ICR)LMTK2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLMTK2
EVEXLMTK2
GoPubMedLMTK2
iHOPLMTK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:13:04 CET 2017

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