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LPAR3 (lysophosphatidic acid receptor 3)

Identity

Alias_namesEDG7
endothelial differentiation
Alias_symbol (synonym)LP-A3
Edg-7
RP4-678I3
HOFNH30
LPA3
Other aliasGPCR
HGNC (Hugo) LPAR3
LocusID (NCBI) 23566
Atlas_Id 43584
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 84813403 and ends at 84893213 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAMTA1 (1p36.31) / LPAR3 (1p22.3)LPAR3 (1p22.3) / ST6GALNAC3 (1p31.1)SIPA1L3 (19q13.13) / LPAR3 (1p22.3)
LPAR3 1p22.3 / ST6GALNAC3 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LPAR3   14298
Cards
Entrez_Gene (NCBI)LPAR3  23566  lysophosphatidic acid receptor 3
AliasesEDG7; Edg-7; GPCR; HOFNH30; 
LP-A3; LPA3; RP4-678I3
GeneCards (Weizmann)LPAR3
Ensembl hg19 (Hinxton)ENSG00000171517 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171517 [Gene_View]  chr1:84813403-84893213 [Contig_View]  LPAR3 [Vega]
ICGC DataPortalENSG00000171517
TCGA cBioPortalLPAR3
AceView (NCBI)LPAR3
Genatlas (Paris)LPAR3
WikiGenes23566
SOURCE (Princeton)LPAR3
Genetics Home Reference (NIH)LPAR3
Genomic and cartography
GoldenPath hg38 (UCSC)LPAR3  -     chr1:84813403-84893213 -  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPAR3  -     1p22.3   [Description]    (hg19-Feb_2009)
EnsemblLPAR3 - 1p22.3 [CytoView hg19]  LPAR3 - 1p22.3 [CytoView hg38]
Mapping of homologs : NCBILPAR3 [Mapview hg19]  LPAR3 [Mapview hg38]
OMIM605106   
Gene and transcription
Genbank (Entrez)AF127138 AF186380 AF236117 AK091731 AK308283
RefSeq transcript (Entrez)NM_012152
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPAR3
Cluster EST : UnigeneHs.674915 [ NCBI ]
CGAP (NCI)Hs.674915
Alternative Splicing GalleryENSG00000171517
Gene ExpressionLPAR3 [ NCBI-GEO ]   LPAR3 [ EBI - ARRAY_EXPRESS ]   LPAR3 [ SEEK ]   LPAR3 [ MEM ]
Gene Expression Viewer (FireBrowse)LPAR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23566
GTEX Portal (Tissue expression)LPAR3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBY5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBY5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBY5
Splice isoforms : SwissVarQ9UBY5
PhosPhoSitePlusQ9UBY5
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    LPA_rcpt    LPA_rcpt_EDG7   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)LPAR3
DMDM Disease mutations23566
Blocks (Seattle)LPAR3
SuperfamilyQ9UBY5
Human Protein AtlasENSG00000171517
Peptide AtlasQ9UBY5
HPRD05486
IPIIPI00015940   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBY5
IntAct (EBI)Q9UBY5
FunCoupENSG00000171517
BioGRIDLPAR3
STRING (EMBL)LPAR3
ZODIACLPAR3
Ontologies - Pathways
QuickGOQ9UBY5
Ontology : AmiGOactivation of MAPK activity  G-protein alpha-subunit binding  G-protein coupled receptor activity  phospholipid binding  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  positive regulation of cytosolic calcium ion concentration  chemical synaptic transmission  lipid binding  axon  bleb assembly  positive regulation of collateral sprouting  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  positive regulation of calcium ion transport  lysophosphatidic acid receptor activity  
Ontology : EGO-EBIactivation of MAPK activity  G-protein alpha-subunit binding  G-protein coupled receptor activity  phospholipid binding  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  positive regulation of cytosolic calcium ion concentration  chemical synaptic transmission  lipid binding  axon  bleb assembly  positive regulation of collateral sprouting  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  positive regulation of calcium ion transport  lysophosphatidic acid receptor activity  
Pathways : BIOCARTARho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation [Genes]   
Pathways : KEGGRap1 signaling pathway    Neuroactive ligand-receptor interaction    PI3K-Akt signaling pathway   
NDEx NetworkLPAR3
Atlas of Cancer Signalling NetworkLPAR3
Wikipedia pathwaysLPAR3
Orthology - Evolution
OrthoDB23566
GeneTree (enSembl)ENSG00000171517
Phylogenetic Trees/Animal Genes : TreeFamLPAR3
HOVERGENQ9UBY5
HOGENOMQ9UBY5
Homologs : HomoloGeneLPAR3
Homology/Alignments : Family Browser (UCSC)LPAR3
Gene fusions - Rearrangements
Fusion : MitelmanLPAR3/ST6GALNAC3 [1p22.3/1p31.1]  
Fusion: TCGALPAR3 1p22.3 ST6GALNAC3 1p31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPAR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPAR3
dbVarLPAR3
ClinVarLPAR3
1000_GenomesLPAR3 
Exome Variant ServerLPAR3
ExAC (Exome Aggregation Consortium)LPAR3 (select the gene name)
Genetic variants : HAPMAP23566
Genomic Variants (DGV)LPAR3 [DGVbeta]
DECIPHERLPAR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPAR3 
Mutations
ICGC Data PortalLPAR3 
TCGA Data PortalLPAR3 
Broad Tumor PortalLPAR3
OASIS PortalLPAR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPAR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLPAR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LPAR3
DgiDB (Drug Gene Interaction Database)LPAR3
DoCM (Curated mutations)LPAR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPAR3 (select a term)
intoGenLPAR3
Cancer3DLPAR3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605106   
Orphanet
MedgenLPAR3
Genetic Testing Registry LPAR3
NextProtQ9UBY5 [Medical]
TSGene23566
GENETestsLPAR3
Huge Navigator LPAR3 [HugePedia]
snp3D : Map Gene to Disease23566
BioCentury BCIQLPAR3
ClinGenLPAR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23566
Chemical/Pharm GKB GenePA162394213
Clinical trialLPAR3
Miscellaneous
canSAR (ICR)LPAR3 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPAR3
EVEXLPAR3
GoPubMedLPAR3
iHOPLPAR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:23:23 CEST 2017

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