LPAR3 (lysophosphatidic acid receptor 3)

2007-02-01  

Identity

HGNC
LPAR3
LOCATION
1p22.3
LOCUSID
23566
ALIAS
EDG7,Edg-7,GPCR,HOFNH30,LP-A3,LPA3,RP4-678I3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23566
MIM: 605106
HGNC: 14298
Ensembl: ENSG00000171517

Variants:

dbSNP: 23566
ClinVar: 23566
TCGA: ENSG00000171517
COSMIC: LPAR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171517ENST00000370611Q9UBY5
ENSG00000171517ENST00000440886Q9UBY5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

References

Pubmed IDYearTitleCitations
190016042008Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.77
188407812009Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.48
180066452008Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?27
264403092015Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3.27
198990772010Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture.24
179231112007Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3.23
186277892008Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms.23
190258912009Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia.17
229228832012Association of autotaxin and lysophosphatidic acid receptor 3 with aggressiveness of human breast carcinoma.16
121238302002Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.15

Citation

Dessen P

LPAR3 (lysophosphatidic acid receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43584/lpar3