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LPL (lipoprotein lipase)

Identity

Other namesHDLCQ11
LIPD
HGNC (Hugo) LPL
LocusID (NCBI) 4023
Location 8p21.3
Location_base_pair Starts at 19796582 and ends at 19824770 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LPL   6677
Cards
Entrez_Gene (NCBI)LPL  4023  lipoprotein lipase
GeneCards (Weizmann)LPL
Ensembl (Hinxton)ENSG00000175445 [Gene_View]  chr8:19796582-19824770 [Contig_View]  LPL [Vega]
AceView (NCBI)LPL
Genatlas (Paris)LPL
WikiGenes4023
SOURCE (Princeton)NM_000237
Genomic and cartography
GoldenPath (UCSC)LPL  -  8p21.3   chr8:19796582-19824770 +  8p21.3   [Description]    (hg19-Feb_2009)
EnsemblLPL - 8p21.3 [CytoView]
Mapping of homologs : NCBILPL [Mapview]
OMIM144250   238600   609708   
Gene and transcription
Genbank (Entrez)AK092286 AK222464 AK290290 AK297164 AK312311
RefSeq transcript (Entrez)NM_000237
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_008855 NT_167187 NW_001839126 NW_004929337
Consensus coding sequences : CCDS (NCBI)LPL
Cluster EST : UnigeneHs.180878 [ NCBI ]
CGAP (NCI)Hs.180878
Alternative Splicing : Fast-db (Paris)GSHG0028855
Alternative Splicing GalleryENSG00000175445
Gene ExpressionLPL [ NCBI-GEO ]     LPL [ SEEK ]   LPL [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06858 (Uniprot)
NextProtP06858  [Medical]
With graphics : InterProP06858
Splice isoforms : SwissVarP06858 (Swissvar)
Catalytic activity : Enzyme3.1.1.34 [ Enzyme-Expasy ]   3.1.1.343.1.1.34 [ IntEnz-EBI ]   3.1.1.34 [ BRENDA ]   3.1.1.34 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)    PLAT (PS50095)   
Domains : Interpro (EBI)Lipase    Lipase_LipOase    Lipase_N    Lipo_Lipase    Lipoprotein_lipase_LIPH    PLAT/LH2_dom   
Related proteins : CluSTrP06858
Domain families : Pfam (Sanger)Lipase (PF00151)    PLAT (PF01477)   
Domain families : Pfam (NCBI)pfam00151    pfam01477   
Domain families : Smart (EMBL)LH2 (SM00308)  
DMDM Disease mutations4023
Blocks (Seattle)P06858
Human Protein AtlasENSG00000175445
Peptide AtlasP06858
HPRD01999
IPIIPI00027847   IPI01011504   IPI00972962   IPI00981202   IPI00984529   IPI00973971   
Protein Interaction databases
DIP (DOE-UCLA)P06858
IntAct (EBI)P06858
FunCoupENSG00000175445
BioGRIDLPL
InParanoidP06858
Interologous Interaction database P06858
IntegromeDBLPL
STRING (EMBL)LPL
Ontologies - Pathways
Ontology : AmiGOretinoid metabolic process  lipoprotein lipase activity  lipoprotein lipase activity  phospholipase activity  triglyceride lipase activity  triglyceride lipase activity  receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  fatty acid biosynthetic process  fatty acid biosynthetic process  fatty acid biosynthetic process  triglyceride metabolic process  phospholipid metabolic process  phototransduction, visible light  heparin binding  cell surface  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol storage  positive regulation of sequestering of triglyceride  triglyceride binding  triglyceride biosynthetic process  triglyceride catabolic process  triglyceride catabolic process  extracellular matrix  anchored to membrane  apolipoprotein binding  very-low-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  very-low-density lipoprotein particle remodeling  lipoprotein metabolic process  response to drug  chylomicron  small molecule metabolic process  triglyceride homeostasis  
Ontology : EGO-EBIretinoid metabolic process  lipoprotein lipase activity  lipoprotein lipase activity  phospholipase activity  triglyceride lipase activity  triglyceride lipase activity  receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  fatty acid biosynthetic process  fatty acid biosynthetic process  fatty acid biosynthetic process  triglyceride metabolic process  phospholipid metabolic process  phototransduction, visible light  heparin binding  cell surface  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol storage  positive regulation of sequestering of triglyceride  triglyceride binding  triglyceride biosynthetic process  triglyceride catabolic process  triglyceride catabolic process  extracellular matrix  anchored to membrane  apolipoprotein binding  very-low-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  very-low-density lipoprotein particle remodeling  lipoprotein metabolic process  response to drug  chylomicron  small molecule metabolic process  triglyceride homeostasis  
Pathways : BIOCARTARole of PPAR-gamma Coactivators in Obesity and Thermogenesis [Genes]    Low-density lipoprotein (LDL) pathway during atherogenesis [Genes]    Visceral Fat Deposits and the Metabolic Syndrome [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGGlycerolipid metabolism    PPAR signaling pathway    Alzheimer's disease   
REACTOMELPL
Protein Interaction DatabaseLPL
Wikipedia pathwaysLPL
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)LPL
SNP (GeneSNP Utah)LPL
SNP : HGBaseLPL
Genetic variants : HAPMAPLPL
1000_GenomesLPL 
ICGC programENSG00000175445 
Somatic Mutations in Cancer : COSMICLPL 
CONAN: Copy Number AnalysisLPL 
Mutations and Diseases : HGMDLPL
OMIM144250    238600    609708   
GENETestsLPL
Disease Genetic AssociationLPL
Huge Navigator LPL [HugePedia]  LPL [HugeCancerGEM]
Genomic VariantsLPL  LPL [DGVbeta]
Exome VariantLPL
dbVarLPL
ClinVarLPL
snp3D : Map Gene to Disease4023
General knowledge
Homologs : HomoloGeneLPL
Homology/Alignments : Family Browser (UCSC)LPL
Phylogenetic Trees/Animal Genes : TreeFamLPL
Chemical/Protein Interactions : CTD4023
Chemical/Pharm GKB GenePA232
Clinical trialLPL
Cancer Resource (Charite)ENSG00000175445
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineLPL
iHOPLPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:12:47 CEST 2014

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