Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1)

Identity

Alias_namesXLKD1
extracellular link domain containing 1
Alias_symbol (synonym)LYVE-1
Other aliasCRSBP-1
HAR
HGNC (Hugo) LYVE1
LocusID (NCBI) 10894
Atlas_Id 42844
Location 1q42.3  [Link to chromosome band 1q42]
Location_base_pair Starts at 10557866 and ends at 10568818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)LYVE1   14687
Cards
Entrez_Gene (NCBI)LYVE1  10894  lymphatic vessel endothelial hyaluronan receptor 1
AliasesCRSBP-1; HAR; LYVE-1; XLKD1
GeneCards (Weizmann)LYVE1
Ensembl hg19 (Hinxton)ENSG00000133800 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133800 [Gene_View]  ENSG00000133800 [Sequence]  chr11:10557866-10568818 [Contig_View]  LYVE1 [Vega]
ICGC DataPortalENSG00000133800
TCGA cBioPortalLYVE1
AceView (NCBI)LYVE1
Genatlas (Paris)LYVE1
WikiGenes10894
SOURCE (Princeton)LYVE1
Genetics Home Reference (NIH)LYVE1
Genomic and cartography
GoldenPath hg38 (UCSC)LYVE1  -     chr11:10557866-10568818 -  1q42.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LYVE1  -     1q42.3   [Description]    (hg19-Feb_2009)
EnsemblLYVE1 - 1q42.3 [CytoView hg19]  LYVE1 - 1q42.3 [CytoView hg38]
Mapping of homologs : NCBILYVE1 [Mapview hg19]  LYVE1 [Mapview hg38]
OMIM605702   
Gene and transcription
Genbank (Entrez)AF118108 AF127670 AK075443 AK300885 AK312462
RefSeq transcript (Entrez)NM_006691
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LYVE1
Cluster EST : UnigeneHs.655332 [ NCBI ]
CGAP (NCI)Hs.655332
Alternative Splicing GalleryENSG00000133800
Gene ExpressionLYVE1 [ NCBI-GEO ]   LYVE1 [ EBI - ARRAY_EXPRESS ]   LYVE1 [ SEEK ]   LYVE1 [ MEM ]
Gene Expression Viewer (FireBrowse)LYVE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10894
GTEX Portal (Tissue expression)LYVE1
Human Protein AtlasENSG00000133800-LYVE1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5Y7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5Y7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5Y7
Splice isoforms : SwissVarQ9Y5Y7
PhosPhoSitePlusQ9Y5Y7
Domaine pattern : Prosite (Expaxy)LINK_2 (PS50963)   
Domains : Interpro (EBI)C-type_lectin-like/link_sf    CTDL_fold    Link_dom   
Domain families : Pfam (Sanger)Xlink (PF00193)   
Domain families : Pfam (NCBI)pfam00193   
Domain families : Smart (EMBL)LINK (SM00445)  
Conserved Domain (NCBI)LYVE1
DMDM Disease mutations10894
Blocks (Seattle)LYVE1
SuperfamilyQ9Y5Y7
Human Protein Atlas [tissue]ENSG00000133800-LYVE1 [tissue]
Peptide AtlasQ9Y5Y7
HPRD05753
IPIIPI00290856   IPI00973908   IPI00908637   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5Y7
IntAct (EBI)Q9Y5Y7
FunCoupENSG00000133800
BioGRIDLYVE1
STRING (EMBL)LYVE1
ZODIACLYVE1
Ontologies - Pathways
QuickGOQ9Y5Y7
Ontology : AmiGOtransmembrane signaling receptor activity  transmembrane signaling receptor activity  protein binding  hyaluronic acid binding  hyaluronic acid binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-matrix adhesion  signal transduction  cell surface receptor signaling pathway  response to wounding  anatomical structure morphogenesis  membrane  hyaluronan catabolic process  signaling receptor activity  extracellular exosome  
Ontology : EGO-EBItransmembrane signaling receptor activity  transmembrane signaling receptor activity  protein binding  hyaluronic acid binding  hyaluronic acid binding  plasma membrane  plasma membrane  integral component of plasma membrane  cell-matrix adhesion  signal transduction  cell surface receptor signaling pathway  response to wounding  anatomical structure morphogenesis  membrane  hyaluronan catabolic process  signaling receptor activity  extracellular exosome  
NDEx NetworkLYVE1
Atlas of Cancer Signalling NetworkLYVE1
Wikipedia pathwaysLYVE1
Orthology - Evolution
OrthoDB10894
GeneTree (enSembl)ENSG00000133800
Phylogenetic Trees/Animal Genes : TreeFamLYVE1
HOVERGENQ9Y5Y7
HOGENOMQ9Y5Y7
Homologs : HomoloGeneLYVE1
Homology/Alignments : Family Browser (UCSC)LYVE1
Gene fusions - Rearrangements
Fusion : QuiverLYVE1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLYVE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LYVE1
dbVarLYVE1
ClinVarLYVE1
1000_GenomesLYVE1 
Exome Variant ServerLYVE1
ExAC (Exome Aggregation Consortium)ENSG00000133800
GNOMAD BrowserENSG00000133800
Varsome BrowserLYVE1
Genetic variants : HAPMAP10894
Genomic Variants (DGV)LYVE1 [DGVbeta]
DECIPHERLYVE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLYVE1 
Mutations
ICGC Data PortalLYVE1 
TCGA Data PortalLYVE1 
Broad Tumor PortalLYVE1
OASIS PortalLYVE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLYVE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLYVE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LYVE1
DgiDB (Drug Gene Interaction Database)LYVE1
DoCM (Curated mutations)LYVE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LYVE1 (select a term)
intoGenLYVE1
Cancer3DLYVE1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605702   
Orphanet
DisGeNETLYVE1
MedgenLYVE1
Genetic Testing Registry LYVE1
NextProtQ9Y5Y7 [Medical]
TSGene10894
GENETestsLYVE1
Target ValidationLYVE1
Huge Navigator LYVE1 [HugePedia]
snp3D : Map Gene to Disease10894
BioCentury BCIQLYVE1
ClinGenLYVE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10894
Chemical/Pharm GKB GenePA162394799
Clinical trialLYVE1
Miscellaneous
canSAR (ICR)LYVE1 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLYVE1
EVEXLYVE1
GoPubMedLYVE1
iHOPLYVE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:12:45 CEST 2018
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