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LZTS2 (leucine zipper tumor suppressor 2)

Identity

Alias (NCBI)LAPSER1
HGNC (Hugo) LZTS2
HGNC Alias symbKIAA1813
LAPSER1
HGNC Previous nameleucine zipper, putative tumor suppressor 2
LocusID (NCBI) 84445
Atlas_Id 41223
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100997071 and ends at 101007830 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LZTS2 (10q24.31) / LZTS2 (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)LZTS2   29381
Cards
Entrez_Gene (NCBI)LZTS2    leucine zipper tumor suppressor 2
AliasesLAPSER1
GeneCards (Weizmann)LZTS2
Ensembl hg19 (Hinxton)ENSG00000107816 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107816 [Gene_View]  ENSG00000107816 [Sequence]  chr10:100997071-101007830 [Contig_View]  LZTS2 [Vega]
ICGC DataPortalENSG00000107816
TCGA cBioPortalLZTS2
AceView (NCBI)LZTS2
Genatlas (Paris)LZTS2
SOURCE (Princeton)LZTS2
Genetics Home Reference (NIH)LZTS2
Genomic and cartography
GoldenPath hg38 (UCSC)LZTS2  -     chr10:100997071-101007830 +  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LZTS2  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathLZTS2 - 10q24.31 [CytoView hg19]  LZTS2 - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000107816
Genome Data Viewer NCBILZTS2 [Mapview hg19]  
OMIM610454   
Gene and transcription
Genbank (Entrez)AB058716 AK097997 AK298208 AL834338 AY029201
RefSeq transcript (Entrez)NM_001318099 NM_001318100 NM_001318101 NM_001394944 NM_001394945 NM_001394946 NM_001394947 NM_001394948 NM_001394949 NM_001394950 NM_001394951 NM_001394952 NM_032429
Consensus coding sequences : CCDS (NCBI)LZTS2
Gene ExpressionLZTS2 [ NCBI-GEO ]   LZTS2 [ EBI - ARRAY_EXPRESS ]   LZTS2 [ SEEK ]   LZTS2 [ MEM ]
Gene Expression Viewer (FireBrowse)LZTS2 [ Firebrowse - Broad ]
GenevisibleExpression of LZTS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84445
GTEX Portal (Tissue expression)LZTS2
Human Protein AtlasENSG00000107816-LZTS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRK4
PhosPhoSitePlusQ9BRK4
Domains : Interpro (EBI)LZTS2   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)LZTS2
SuperfamilyQ9BRK4
AlphaFold pdb e-kbQ9BRK4   
Human Protein Atlas [tissue]ENSG00000107816-LZTS2 [tissue]
HPRD14341
Protein Interaction databases
DIP (DOE-UCLA)Q9BRK4
IntAct (EBI)Q9BRK4
BioGRIDLZTS2
STRING (EMBL)LZTS2
ZODIACLZTS2
Ontologies - Pathways
QuickGOQ9BRK4
Ontology : AmiGOmitotic cytokinesis  protein binding  centrosome  cytosol  microtubule  plasma membrane  negative regulation of cell population proliferation  Wnt signaling pathway  midbody  vesicle  microtubule severing  nuclear export  spindle midzone assembly  primary ureteric bud growth  ureter morphogenesis  negative regulation of canonical Wnt signaling pathway  negative regulation of protein localization to nucleus  
Ontology : EGO-EBImitotic cytokinesis  protein binding  centrosome  cytosol  microtubule  plasma membrane  negative regulation of cell population proliferation  Wnt signaling pathway  midbody  vesicle  microtubule severing  nuclear export  spindle midzone assembly  primary ureteric bud growth  ureter morphogenesis  negative regulation of canonical Wnt signaling pathway  negative regulation of protein localization to nucleus  
NDEx NetworkLZTS2
Atlas of Cancer Signalling NetworkLZTS2
Wikipedia pathwaysLZTS2
Orthology - Evolution
OrthoDB84445
GeneTree (enSembl)ENSG00000107816
Phylogenetic Trees/Animal Genes : TreeFamLZTS2
Homologs : HomoloGeneLZTS2
Homology/Alignments : Family Browser (UCSC)LZTS2
Gene fusions - Rearrangements
Fusion : QuiverLZTS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLZTS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LZTS2
dbVarLZTS2
ClinVarLZTS2
MonarchLZTS2
1000_GenomesLZTS2 
Exome Variant ServerLZTS2
GNOMAD BrowserENSG00000107816
Varsome BrowserLZTS2
ACMGLZTS2 variants
VarityQ9BRK4
Genomic Variants (DGV)LZTS2 [DGVbeta]
DECIPHERLZTS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLZTS2 
Mutations
ICGC Data PortalLZTS2 
TCGA Data PortalLZTS2 
Broad Tumor PortalLZTS2
OASIS PortalLZTS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLZTS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLZTS2
Mutations and Diseases : HGMDLZTS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaLZTS2
DgiDB (Drug Gene Interaction Database)LZTS2
DoCM (Curated mutations)LZTS2
CIViC (Clinical Interpretations of Variants in Cancer)LZTS2
Cancer3DLZTS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610454   
Orphanet
DisGeNETLZTS2
MedgenLZTS2
Genetic Testing Registry LZTS2
NextProtQ9BRK4 [Medical]
GENETestsLZTS2
Target ValidationLZTS2
Huge Navigator LZTS2 [HugePedia]
ClinGenLZTS2
Clinical trials, drugs, therapy
MyCancerGenomeLZTS2
Protein Interactions : CTDLZTS2
Pharm GKB GenePA134944540
PharosQ9BRK4
Clinical trialLZTS2
Miscellaneous
canSAR (ICR)LZTS2
HarmonizomeLZTS2
DataMed IndexLZTS2
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXLZTS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:22 CEST 2021

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