MAEL (maelstrom spermatogenic transposon silencer)

2010-10-01  

Identity

HGNC
LOCATION
1q24.1
LOCUSID
ALIAS
CT128,SPATA35
FUSION GENES

Other Information

Locus ID:

NCBI: 84944
MIM: 611368
HGNC: 25929
Ensembl: ENSG00000143194

Variants:

dbSNP: 84944
ClinVar: 84944
TCGA: ENSG00000143194
COSMIC: MAEL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143194ENST00000367870Q96JY0
ENSG00000143194ENST00000367872Q96JY0
ENSG00000143194ENST00000367872A0A140VJP0
ENSG00000143194ENST00000447624X6RGB1
ENSG00000143194ENST00000622874E9JVC4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
239297942014Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling.41
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
196936942010Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation.12
271812052016Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3B.11
241896372014Proteomic analysis reveals that MAEL, a component of nuage, interacts with stress granule proteins in cancer cells.4
283429262017Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.4
275372532016MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer.3
279265132017Mael is essential for cancer cell survival and tumorigenesis through protection of genetic integrity.2

Citation

Dessen P

MAEL (maelstrom spermatogenic transposon silencer)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51735/mael