MANF (mesencephalic astrocyte derived neurotrophic factor)

2003-02-01  

Identity

HGNC
MANF
LOCATION
3p21.2
LOCUSID
7873
ALIAS
ARMET,ARP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7873
MIM: 601916
HGNC: 15461
Ensembl: ENSG00000145050

Variants:

dbSNP: 7873
ClinVar: 7873
TCGA: ENSG00000145050
COSMIC: MANF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145050ENST00000446668H7C2D6
ENSG00000145050ENST00000528157P55145
ENSG00000145050ENST00000528157A8K878

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185619142008Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death.91
187188662008MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.51
210477802011Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.50
232556012013Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors.46
192584492009The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.36
206853132010Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury.34
239561752013Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.22
267203412015Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.20
273564712016Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes.17
294970572018Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.15

Citation

Dessen P

MANF (mesencephalic astrocyte derived neurotrophic factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/707/manf