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MANF (mesencephalic astrocyte derived neurotrophic factor)

Identity

Alias_namesARMET
arginine-rich, mutated in early stage tumors
mesencephalic astrocyte-derived neurotrophic factor
Alias_symbol (synonym)ARP
Other alias
HGNC (Hugo) MANF
LocusID (NCBI) 7873
Atlas_Id 707
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 51385237 and ends at 51389397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MANF (3p21.2) / SETD2 (3p21.31)MANF 3p21.2 / SETD2 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MANF   15461
Cards
Entrez_Gene (NCBI)MANF  7873  mesencephalic astrocyte derived neurotrophic factor
AliasesARMET; ARP
GeneCards (Weizmann)MANF
Ensembl hg19 (Hinxton)ENSG00000145050 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145050 [Gene_View]  chr3:51385237-51389397 [Contig_View]  MANF [Vega]
ICGC DataPortalENSG00000145050
TCGA cBioPortalMANF
AceView (NCBI)MANF
Genatlas (Paris)MANF
WikiGenes7873
SOURCE (Princeton)MANF
Genetics Home Reference (NIH)MANF
Genomic and cartography
GoldenPath hg38 (UCSC)MANF  -     chr3:51385237-51389397 +  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MANF  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblMANF - 3p21.2 [CytoView hg19]  MANF - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIMANF [Mapview hg19]  MANF [Mapview hg38]
OMIM601916   
Gene and transcription
Genbank (Entrez)AK292243 BC007282 BC033055 BC113588 BC113590
RefSeq transcript (Entrez)NM_006010
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MANF
Cluster EST : UnigeneHs.436446 [ NCBI ]
CGAP (NCI)Hs.436446
Alternative Splicing GalleryENSG00000145050
Gene ExpressionMANF [ NCBI-GEO ]   MANF [ EBI - ARRAY_EXPRESS ]   MANF [ SEEK ]   MANF [ MEM ]
Gene Expression Viewer (FireBrowse)MANF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7873
GTEX Portal (Tissue expression)MANF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55145   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55145  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55145
Splice isoforms : SwissVarP55145
PhosPhoSitePlusP55145
Domains : Interpro (EBI)Armet_prot    Saposin-like   
Domain families : Pfam (Sanger)Armet (PF10208)   
Domain families : Pfam (NCBI)pfam10208   
Conserved Domain (NCBI)MANF
DMDM Disease mutations7873
Blocks (Seattle)MANF
PDB (SRS)2KVD    2KVE    2W51   
PDB (PDBSum)2KVD    2KVE    2W51   
PDB (IMB)2KVD    2KVE    2W51   
PDB (RSDB)2KVD    2KVE    2W51   
Structural Biology KnowledgeBase2KVD    2KVE    2W51   
SCOP (Structural Classification of Proteins)2KVD    2KVE    2W51   
CATH (Classification of proteins structures)2KVD    2KVE    2W51   
SuperfamilyP55145
Human Protein AtlasENSG00000145050
Peptide AtlasP55145
HPRD03558
IPIIPI00980165   IPI00328748   IPI00924819   
Protein Interaction databases
DIP (DOE-UCLA)P55145
IntAct (EBI)P55145
FunCoupENSG00000145050
BioGRIDMANF
STRING (EMBL)MANF
ZODIACMANF
Ontologies - Pathways
QuickGOP55145
Ontology : AmiGOplatelet degranulation  RNA binding  extracellular region  extracellular space  nucleus  endoplasmic reticulum  cytosol  response to unfolded protein  growth factor activity  biological_process  neuron projection development  dopaminergic neuron differentiation  
Ontology : EGO-EBIplatelet degranulation  RNA binding  extracellular region  extracellular space  nucleus  endoplasmic reticulum  cytosol  response to unfolded protein  growth factor activity  biological_process  neuron projection development  dopaminergic neuron differentiation  
NDEx NetworkMANF
Atlas of Cancer Signalling NetworkMANF
Wikipedia pathwaysMANF
Orthology - Evolution
OrthoDB7873
GeneTree (enSembl)ENSG00000145050
Phylogenetic Trees/Animal Genes : TreeFamMANF
HOVERGENP55145
HOGENOMP55145
Homologs : HomoloGeneMANF
Homology/Alignments : Family Browser (UCSC)MANF
Gene fusions - Rearrangements
Fusion : MitelmanMANF/SETD2 [3p21.2/3p21.31]  
Fusion: TCGAMANF 3p21.2 SETD2 3p21.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMANF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MANF
dbVarMANF
ClinVarMANF
1000_GenomesMANF 
Exome Variant ServerMANF
ExAC (Exome Aggregation Consortium)MANF (select the gene name)
Genetic variants : HAPMAP7873
Genomic Variants (DGV)MANF [DGVbeta]
DECIPHERMANF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMANF 
Mutations
ICGC Data PortalMANF 
TCGA Data PortalMANF 
Broad Tumor PortalMANF
OASIS PortalMANF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMANF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMANF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MANF
DgiDB (Drug Gene Interaction Database)MANF
DoCM (Curated mutations)MANF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MANF (select a term)
intoGenMANF
Cancer3DMANF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601916   
Orphanet
MedgenMANF
Genetic Testing Registry MANF
NextProtP55145 [Medical]
TSGene7873
GENETestsMANF
Huge Navigator MANF [HugePedia]
snp3D : Map Gene to Disease7873
BioCentury BCIQMANF
ClinGenMANF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7873
Chemical/Pharm GKB GenePA24993
Clinical trialMANF
Miscellaneous
canSAR (ICR)MANF (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMANF
EVEXMANF
GoPubMedMANF
iHOPMANF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:01 CEST 2017

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