Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP3K11 (mitogen-activated protein kinase kinase kinase 11)

Identity

Alias_namesMLK3
PTK1
Alias_symbol (synonym)SPRK
MEKK11
HGNC (Hugo) MAP3K11
LocusID (NCBI) 4296
Atlas_Id 41277
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65365226 and ends at 65381720 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP3K11   6850
Cards
Entrez_Gene (NCBI)MAP3K11  4296  mitogen-activated protein kinase kinase kinase 11
AliasesMEKK11; MLK-3; MLK3; PTK1; 
SPRK
GeneCards (Weizmann)MAP3K11
Ensembl hg19 (Hinxton)ENSG00000173327 [Gene_View]  chr11:65365226-65381720 [Contig_View]  MAP3K11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000173327 [Gene_View]  chr11:65365226-65381720 [Contig_View]  MAP3K11 [Vega]
ICGC DataPortalENSG00000173327
TCGA cBioPortalMAP3K11
AceView (NCBI)MAP3K11
Genatlas (Paris)MAP3K11
WikiGenes4296
SOURCE (Princeton)MAP3K11
Genetics Home Reference (NIH)MAP3K11
Genomic and cartography
GoldenPath hg19 (UCSC)MAP3K11  -     chr11:65365226-65381720 -  11q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP3K11  -     11q13.1   [Description]    (hg38-Dec_2013)
EnsemblMAP3K11 - 11q13.1 [CytoView hg19]  MAP3K11 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIMAP3K11 [Mapview hg19]  MAP3K11 [Mapview hg38]
OMIM600050   
Gene and transcription
Genbank (Entrez)AB209655 AK057256 AK090614 AK092015 AK222781
RefSeq transcript (Entrez)NM_002419
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)MAP3K11
Cluster EST : UnigeneHs.502872 [ NCBI ]
CGAP (NCI)Hs.502872
Alternative Splicing GalleryENSG00000173327
Gene ExpressionMAP3K11 [ NCBI-GEO ]   MAP3K11 [ EBI - ARRAY_EXPRESS ]   MAP3K11 [ SEEK ]   MAP3K11 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4296
GTEX Portal (Tissue expression)MAP3K11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16584   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16584  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16584
Splice isoforms : SwissVarQ16584
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ16584
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    SH3_domain    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam07714    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)MAP3K11
DMDM Disease mutations4296
Blocks (Seattle)MAP3K11
SuperfamilyQ16584
Human Protein AtlasENSG00000173327
Peptide AtlasQ16584
HPRD02502
IPIIPI00000977   IPI00982713   IPI00976246   IPI00982034   IPI00984692   IPI00983901   
Protein Interaction databases
DIP (DOE-UCLA)Q16584
IntAct (EBI)Q16584
FunCoupENSG00000173327
BioGRIDMAP3K11
STRING (EMBL)MAP3K11
ZODIACMAP3K11
Ontologies - Pathways
QuickGOQ16584
Ontology : AmiGOactivation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  centrosome  microtubule  protein phosphorylation  microtubule-based process  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  cell death  cell proliferation  membrane  mitogen-activated protein kinase kinase binding  mitogen-activated protein kinase kinase kinase binding  identical protein binding  protein homodimerization activity  positive regulation of JUN kinase activity  positive regulation of neuron apoptotic process  positive regulation of JNK cascade  protein autophosphorylation  Rac GTPase binding  
Ontology : EGO-EBIactivation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  centrosome  microtubule  protein phosphorylation  microtubule-based process  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  cell death  cell proliferation  membrane  mitogen-activated protein kinase kinase binding  mitogen-activated protein kinase kinase kinase binding  identical protein binding  protein homodimerization activity  positive regulation of JUN kinase activity  positive regulation of neuron apoptotic process  positive regulation of JNK cascade  protein autophosphorylation  Rac GTPase binding  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Non-alcoholic fatty liver disease (NAFLD)   
NDEx NetworkMAP3K11
Atlas of Cancer Signalling NetworkMAP3K11
Wikipedia pathwaysMAP3K11
Orthology - Evolution
OrthoDB4296
GeneTree (enSembl)ENSG00000173327
Phylogenetic Trees/Animal Genes : TreeFamMAP3K11
HOVERGENQ16584
HOGENOMQ16584
Homologs : HomoloGeneMAP3K11
Homology/Alignments : Family Browser (UCSC)MAP3K11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K11
dbVarMAP3K11
ClinVarMAP3K11
1000_GenomesMAP3K11 
Exome Variant ServerMAP3K11
ExAC (Exome Aggregation Consortium)MAP3K11 (select the gene name)
Genetic variants : HAPMAP4296
Genomic Variants (DGV)MAP3K11 [DGVbeta]
DECIPHER (Syndromes)11:65365226-65381720  ENSG00000173327
CONAN: Copy Number AnalysisMAP3K11 
Mutations
ICGC Data PortalMAP3K11 
TCGA Data PortalMAP3K11 
Broad Tumor PortalMAP3K11
OASIS PortalMAP3K11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K11
intOGen PortalMAP3K11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K11
DgiDB (Drug Gene Interaction Database)MAP3K11
DoCM (Curated mutations)MAP3K11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K11 (select a term)
intoGenMAP3K11
Cancer3DMAP3K11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600050   
Orphanet
MedgenMAP3K11
Genetic Testing Registry MAP3K11
NextProtQ16584 [Medical]
TSGene4296
GENETestsMAP3K11
Huge Navigator MAP3K11 [HugePedia]
snp3D : Map Gene to Disease4296
BioCentury BCIQMAP3K11
ClinGenMAP3K11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4296
Chemical/Pharm GKB GenePA30594
Clinical trialMAP3K11
Miscellaneous
canSAR (ICR)MAP3K11 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K11
EVEXMAP3K11
GoPubMedMAP3K11
iHOPMAP3K11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:42:54 CET 2016

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