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MAP3K11 (mitogen-activated protein kinase kinase kinase 11)

Identity

Other namesMEKK11
MLK-3
MLK3
PTK1
SPRK
HGNC (Hugo) MAP3K11
LocusID (NCBI) 4296
Location 11q13.1
Location_base_pair Starts at 65365226 and ends at 65381720 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP3K11   6850
Cards
Entrez_Gene (NCBI)MAP3K11  4296  mitogen-activated protein kinase kinase kinase 11
GeneCards (Weizmann)MAP3K11
Ensembl (Hinxton)ENSG00000173327 [Gene_View]  chr11:65365226-65381720 [Contig_View]  MAP3K11 [Vega]
ICGC DataPortalENSG00000173327
cBioPortalMAP3K11
AceView (NCBI)MAP3K11
Genatlas (Paris)MAP3K11
WikiGenes4296
SOURCE (Princeton)NM_002419
Genomic and cartography
GoldenPath (UCSC)MAP3K11  -  11q13.1   chr11:65365226-65381720 -  11q13.1   [Description]    (hg19-Feb_2009)
EnsemblMAP3K11 - 11q13.1 [CytoView]
Mapping of homologs : NCBIMAP3K11 [Mapview]
OMIM600050   
Gene and transcription
Genbank (Entrez)AB209655 AK057256 AK090614 AK092015 AK222781
RefSeq transcript (Entrez)NM_002419
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NT_167190 NW_001838025 NW_004929380
Consensus coding sequences : CCDS (NCBI)MAP3K11
Cluster EST : UnigeneHs.502872 [ NCBI ]
CGAP (NCI)Hs.502872
Alternative Splicing : Fast-db (Paris)GSHG0005903
Alternative Splicing GalleryENSG00000173327
Gene ExpressionMAP3K11 [ NCBI-GEO ]     MAP3K11 [ SEEK ]   MAP3K11 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16584 (Uniprot)
NextProtQ16584  [Medical]
With graphics : InterProQ16584
Splice isoforms : SwissVarQ16584 (Swissvar)
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   MAPKKK9/10/11 [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   Ser/Thr_kinase_AS [organisation]   SH3_domain [organisation]   Tyr_kinase_cat_dom [organisation]  
Related proteins : CluSTrQ16584
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam07714    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  TyrKc (SM00219)  
DMDM Disease mutations4296
Blocks (Seattle)Q16584
Human Protein AtlasENSG00000173327 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ16584
HPRD02502
IPIIPI00000977   IPI00982713   IPI00976246   IPI00982034   IPI00984692   IPI00983901   
Protein Interaction databases
DIP (DOE-UCLA)Q16584
IntAct (EBI)Q16584
FunCoupENSG00000173327
BioGRIDMAP3K11
InParanoidQ16584
Interologous Interaction database Q16584
IntegromeDBMAP3K11
STRING (EMBL)MAP3K11
Ontologies - Pathways
Ontology : AmiGOmitotic G1 phase  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  centrosome  microtubule  protein phosphorylation  microtubule-based process  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  cell death  cell proliferation  membrane  peptidyl-tyrosine phosphorylation  mitogen-activated protein kinase kinase binding  mitogen-activated protein kinase kinase kinase binding  identical protein binding  protein homodimerization activity  positive regulation of JUN kinase activity  positive regulation of neuron apoptotic process  positive regulation of JNK cascade  protein autophosphorylation  Rac GTPase binding  
Ontology : EGO-EBImitotic G1 phase  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  centrosome  microtubule  protein phosphorylation  microtubule-based process  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  cell death  cell proliferation  membrane  peptidyl-tyrosine phosphorylation  mitogen-activated protein kinase kinase binding  mitogen-activated protein kinase kinase kinase binding  identical protein binding  protein homodimerization activity  positive regulation of JUN kinase activity  positive regulation of neuron apoptotic process  positive regulation of JNK cascade  protein autophosphorylation  Rac GTPase binding  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Non-alcoholic fatty liver disease (NAFLD)   
Protein Interaction DatabaseMAP3K11
Wikipedia pathwaysMAP3K11
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP3K11
snp3D : Map Gene to Disease4296
SNP (GeneSNP Utah)MAP3K11
SNP : HGBaseMAP3K11
Genetic variants : HAPMAPMAP3K11
Exome VariantMAP3K11
1000_GenomesMAP3K11 
ICGC programENSG00000173327 
Somatic Mutations in Cancer : COSMICMAP3K11 
CONAN: Copy Number AnalysisMAP3K11 
Mutations and Diseases : HGMDMAP3K11
Genomic VariantsMAP3K11  MAP3K11 [DGVbeta]
dbVarMAP3K11
ClinVarMAP3K11
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM600050   
MedgenMAP3K11
GENETestsMAP3K11
Disease Genetic AssociationMAP3K11
Huge Navigator MAP3K11 [HugePedia]  MAP3K11 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMAP3K11
Homology/Alignments : Family Browser (UCSC)MAP3K11
Phylogenetic Trees/Animal Genes : TreeFamMAP3K11
Chemical/Protein Interactions : CTD4296
Chemical/Pharm GKB GenePA30594
Clinical trialMAP3K11
Cancer Resource (Charite)ENSG00000173327
Other databases
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
CoreMineMAP3K11
iHOPMAP3K11
OncoSearchMAP3K11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:38:19 CEST 2014

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