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MAP3K6 (mitogen-activated protein kinase kinase kinase 6)

Identity

Alias_symbol (synonym)MAPKKK6
ASK2
MEKK6
Other alias
HGNC (Hugo) MAP3K6
LocusID (NCBI) 9064
Atlas_Id 43344
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 27355179 and ends at 27366866 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP3K6 (1p36.11) / MAP3K6 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP3K6   6858
LRG (Locus Reference Genomic)LRG_1086
Cards
Entrez_Gene (NCBI)MAP3K6  9064  mitogen-activated protein kinase kinase kinase 6
AliasesASK2; MAPKKK6; MEKK6
GeneCards (Weizmann)MAP3K6
Ensembl hg19 (Hinxton)ENSG00000142733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142733 [Gene_View]  chr1:27355179-27366866 [Contig_View]  MAP3K6 [Vega]
ICGC DataPortalENSG00000142733
TCGA cBioPortalMAP3K6
AceView (NCBI)MAP3K6
Genatlas (Paris)MAP3K6
WikiGenes9064
SOURCE (Princeton)MAP3K6
Genetics Home Reference (NIH)MAP3K6
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K6  -     chr1:27355179-27366866 -  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K6  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblMAP3K6 - 1p36.11 [CytoView hg19]  MAP3K6 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBIMAP3K6 [Mapview hg19]  MAP3K6 [Mapview hg38]
OMIM604468   
Gene and transcription
Genbank (Entrez)AB167411 AB208805 AF100318 AI582755 AI658745
RefSeq transcript (Entrez)NM_001297609 NM_004672
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K6
Cluster EST : UnigeneHs.194694 [ NCBI ]
CGAP (NCI)Hs.194694
Alternative Splicing GalleryENSG00000142733
Gene ExpressionMAP3K6 [ NCBI-GEO ]   MAP3K6 [ EBI - ARRAY_EXPRESS ]   MAP3K6 [ SEEK ]   MAP3K6 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9064
GTEX Portal (Tissue expression)MAP3K6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95382   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95382  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95382
Splice isoforms : SwissVarO95382
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusO95382
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DUF4071    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM/pointed    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF4071 (PF13281)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam13281    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K6
DMDM Disease mutations9064
Blocks (Seattle)MAP3K6
SuperfamilyO95382
Human Protein AtlasENSG00000142733
Peptide AtlasO95382
HPRD05126
IPIIPI00418221   IPI00642537   IPI00847283   IPI00795936   
Protein Interaction databases
DIP (DOE-UCLA)O95382
IntAct (EBI)O95382
FunCoupENSG00000142733
BioGRIDMAP3K6
STRING (EMBL)MAP3K6
ZODIACMAP3K6
Ontologies - Pathways
QuickGOO95382
Ontology : AmiGOactivation of MAPKK activity  magnesium ion binding  MAP kinase kinase kinase activity  ATP binding  intracellular  protein phosphorylation  signal transduction  activation of JUN kinase activity  
Ontology : EGO-EBIactivation of MAPKK activity  magnesium ion binding  MAP kinase kinase kinase activity  ATP binding  intracellular  protein phosphorylation  signal transduction  activation of JUN kinase activity  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP3K6
Atlas of Cancer Signalling NetworkMAP3K6
Wikipedia pathwaysMAP3K6
Orthology - Evolution
OrthoDB9064
GeneTree (enSembl)ENSG00000142733
Phylogenetic Trees/Animal Genes : TreeFamMAP3K6
HOVERGENO95382
HOGENOMO95382
Homologs : HomoloGeneMAP3K6
Homology/Alignments : Family Browser (UCSC)MAP3K6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K6
dbVarMAP3K6
ClinVarMAP3K6
1000_GenomesMAP3K6 
Exome Variant ServerMAP3K6
ExAC (Exome Aggregation Consortium)MAP3K6 (select the gene name)
Genetic variants : HAPMAP9064
Genomic Variants (DGV)MAP3K6 [DGVbeta]
DECIPHERMAP3K6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K6 
Mutations
ICGC Data PortalMAP3K6 
TCGA Data PortalMAP3K6 
Broad Tumor PortalMAP3K6
OASIS PortalMAP3K6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K6
DgiDB (Drug Gene Interaction Database)MAP3K6
DoCM (Curated mutations)MAP3K6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K6 (select a term)
intoGenMAP3K6
Cancer3DMAP3K6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604468   
Orphanet8758   
MedgenMAP3K6
Genetic Testing Registry MAP3K6
NextProtO95382 [Medical]
TSGene9064
GENETestsMAP3K6
Target ValidationMAP3K6
Huge Navigator MAP3K6 [HugePedia]
snp3D : Map Gene to Disease9064
BioCentury BCIQMAP3K6
ClinGenMAP3K6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9064
Chemical/Pharm GKB GenePA30602
Clinical trialMAP3K6
Miscellaneous
canSAR (ICR)MAP3K6 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K6
EVEXMAP3K6
GoPubMedMAP3K6
iHOPMAP3K6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:42:12 CEST 2017

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