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MAPKAP1 (mitogen-activated protein kinase associated protein 1)

Identity

Alias_symbol (synonym)MGC2745
SIN1
MIP1
Other aliasJC310
SIN1b
SIN1g
HGNC (Hugo) MAPKAP1
LocusID (NCBI) 79109
Atlas_Id 49954
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 125437394 and ends at 125707234 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTSL2 (9q34.2) / MAPKAP1 (9q33.3)MAPKAP1 (9q33.3) / AP1G2 (14q11.2)MAPKAP1 (9q33.3) / KCTD10 (12q24.11)
MAPKAP1 (9q33.3) / PRRC2B (9q34.13)MAPKAP1 (9q33.3) / UHRF1 (19p13.3)MAPKAP1 (9q33.3) / VAV2 (9q34.2)
SPTAN1 (9q34.11) / MAPKAP1 (9q33.3)ADAMTSL2 9q34.2 / MAPKAP1 9q33.3MAPKAP1 9q33.3 / AP1G2 14q11.2
MAPKAP1 9q33.3 / PRRC2B 9q34.13MAPKAP1 9q33.3 / UHRF1 19p13.3MAPKAP1 9q33.3 / VAV2 9q34.2
SPTAN1 9q34.11 / MAPKAP1 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAPKAP1   18752
Cards
Entrez_Gene (NCBI)MAPKAP1  79109  mitogen-activated protein kinase associated protein 1
AliasesJC310; MIP1; SIN1; SIN1b; 
SIN1g
GeneCards (Weizmann)MAPKAP1
Ensembl hg19 (Hinxton)ENSG00000119487 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119487 [Gene_View]  chr9:125437394-125707234 [Contig_View]  MAPKAP1 [Vega]
ICGC DataPortalENSG00000119487
TCGA cBioPortalMAPKAP1
AceView (NCBI)MAPKAP1
Genatlas (Paris)MAPKAP1
WikiGenes79109
SOURCE (Princeton)MAPKAP1
Genetics Home Reference (NIH)MAPKAP1
Genomic and cartography
GoldenPath hg38 (UCSC)MAPKAP1  -     chr9:125437394-125707234 -  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPKAP1  -     9q33.3   [Description]    (hg19-Feb_2009)
EnsemblMAPKAP1 - 9q33.3 [CytoView hg19]  MAPKAP1 - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBIMAPKAP1 [Mapview hg19]  MAPKAP1 [Mapview hg38]
OMIM610558   
Gene and transcription
Genbank (Entrez)AK290060 AK295364 AK298841 AK309507 AK310361
RefSeq transcript (Entrez)NM_001006617 NM_001006618 NM_001006619 NM_001006620 NM_001006621 NM_024117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAPKAP1
Cluster EST : UnigeneHs.495138 [ NCBI ]
CGAP (NCI)Hs.495138
Alternative Splicing GalleryENSG00000119487
Gene ExpressionMAPKAP1 [ NCBI-GEO ]   MAPKAP1 [ EBI - ARRAY_EXPRESS ]   MAPKAP1 [ SEEK ]   MAPKAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPKAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79109
GTEX Portal (Tissue expression)MAPKAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BPZ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BPZ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BPZ7
Splice isoforms : SwissVarQ9BPZ7
PhosPhoSitePlusQ9BPZ7
Domains : Interpro (EBI)CRIM_dom    Sin1/Avo1    Sin1_N    Sin1_PH_dom   
Domain families : Pfam (Sanger)CRIM (PF16978)    SIN1 (PF05422)    SIN1_PH (PF16979)   
Domain families : Pfam (NCBI)pfam16978    pfam05422    pfam16979   
Conserved Domain (NCBI)MAPKAP1
DMDM Disease mutations79109
Blocks (Seattle)MAPKAP1
PDB (SRS)3VOQ   
PDB (PDBSum)3VOQ   
PDB (IMB)3VOQ   
PDB (RSDB)3VOQ   
Structural Biology KnowledgeBase3VOQ   
SCOP (Structural Classification of Proteins)3VOQ   
CATH (Classification of proteins structures)3VOQ   
SuperfamilyQ9BPZ7
Human Protein AtlasENSG00000119487
Peptide AtlasQ9BPZ7
HPRD17464
IPIIPI00028195   IPI00216277   IPI00550208   IPI00549688   IPI00549186   IPI00890691   IPI00552811   IPI00921964   IPI00450449   IPI00642703   IPI00645205   IPI00645884   IPI00553011   IPI00871706   IPI01011699   
Protein Interaction databases
DIP (DOE-UCLA)Q9BPZ7
IntAct (EBI)Q9BPZ7
FunCoupENSG00000119487
BioGRIDMAPKAP1
STRING (EMBL)MAPKAP1
ZODIACMAPKAP1
Ontologies - Pathways
QuickGOQ9BPZ7
Ontology : AmiGOprotein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  Ras GTPase binding  protein kinase binding  substantia nigra development  establishment or maintenance of actin cytoskeleton polarity  stress-activated protein kinase signaling cascade  T cell costimulation  cytoplasmic vesicle  TORC2 complex  TORC2 signaling  phosphatidylinositol-3,4-bisphosphate binding  negative regulation of Ras protein signal transduction  phosphatidylinositol-mediated signaling  phosphatidic acid binding  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBIprotein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  Ras GTPase binding  protein kinase binding  substantia nigra development  establishment or maintenance of actin cytoskeleton polarity  stress-activated protein kinase signaling cascade  T cell costimulation  cytoplasmic vesicle  TORC2 complex  TORC2 signaling  phosphatidylinositol-3,4-bisphosphate binding  negative regulation of Ras protein signal transduction  phosphatidylinositol-mediated signaling  phosphatidic acid binding  phosphatidylinositol-3,5-bisphosphate binding  
NDEx NetworkMAPKAP1
Atlas of Cancer Signalling NetworkMAPKAP1
Wikipedia pathwaysMAPKAP1
Orthology - Evolution
OrthoDB79109
GeneTree (enSembl)ENSG00000119487
Phylogenetic Trees/Animal Genes : TreeFamMAPKAP1
HOVERGENQ9BPZ7
HOGENOMQ9BPZ7
Homologs : HomoloGeneMAPKAP1
Homology/Alignments : Family Browser (UCSC)MAPKAP1
Gene fusions - Rearrangements
Fusion : MitelmanADAMTSL2/MAPKAP1 [9q34.2/9q33.3]  [t(9;9)(q33;q34)]  
Fusion : MitelmanMAPKAP1/AP1G2 [9q33.3/14q11.2]  [t(9;14)(q33;q11)]  
Fusion : MitelmanMAPKAP1/PRRC2B [9q33.3/9q34.13]  [t(9;9)(q33;q34)]  
Fusion : MitelmanMAPKAP1/UHRF1 [9q33.3/19p13.3]  [t(9;19)(q33;p13)]  
Fusion : MitelmanMAPKAP1/VAV2 [9q33.3/9q34.2]  [t(9;9)(q33;q34)]  
Fusion : MitelmanSPTAN1/MAPKAP1 [9q34.11/9q33.3]  [t(9;9)(q33;q34)]  
Fusion: TCGAADAMTSL2 9q34.2 MAPKAP1 9q33.3 LUSC
Fusion: TCGAMAPKAP1 9q33.3 AP1G2 14q11.2 BLCA
Fusion: TCGAMAPKAP1 9q33.3 PRRC2B 9q34.13 BRCA
Fusion: TCGAMAPKAP1 9q33.3 UHRF1 19p13.3 LUAD
Fusion: TCGAMAPKAP1 9q33.3 VAV2 9q34.2 BRCA
Fusion: TCGASPTAN1 9q34.11 MAPKAP1 9q33.3 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPKAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPKAP1
dbVarMAPKAP1
ClinVarMAPKAP1
1000_GenomesMAPKAP1 
Exome Variant ServerMAPKAP1
ExAC (Exome Aggregation Consortium)MAPKAP1 (select the gene name)
Genetic variants : HAPMAP79109
Genomic Variants (DGV)MAPKAP1 [DGVbeta]
DECIPHERMAPKAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPKAP1 
Mutations
ICGC Data PortalMAPKAP1 
TCGA Data PortalMAPKAP1 
Broad Tumor PortalMAPKAP1
OASIS PortalMAPKAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPKAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPKAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPKAP1
DgiDB (Drug Gene Interaction Database)MAPKAP1
DoCM (Curated mutations)MAPKAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPKAP1 (select a term)
intoGenMAPKAP1
Cancer3DMAPKAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610558   
Orphanet
MedgenMAPKAP1
Genetic Testing Registry MAPKAP1
NextProtQ9BPZ7 [Medical]
TSGene79109
GENETestsMAPKAP1
Target ValidationMAPKAP1
Huge Navigator MAPKAP1 [HugePedia]
snp3D : Map Gene to Disease79109
BioCentury BCIQMAPKAP1
ClinGenMAPKAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79109
Chemical/Pharm GKB GenePA38674
Clinical trialMAPKAP1
Miscellaneous
canSAR (ICR)MAPKAP1 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPKAP1
EVEXMAPKAP1
GoPubMedMAPKAP1
iHOPMAPKAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:18 CEST 2017

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