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MARCKSL1 (MARCKS like 1)

Identity

Alias_namesMLP
MARCKS-like protein
Alias_symbol (synonym)F52
MacMARCKS
MLP1
Other aliasMACMARCKS
MRP
HGNC (Hugo) MARCKSL1
LocusID (NCBI) 65108
Atlas_Id 41380
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 32333829 and ends at 32336239 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MARCKSL1 (1p35.1) / MARCKSL1 (1p35.1)MARCKSL1 (1p35.1) / PRKAR1B (7p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(1)(p35p36) MARCKSL1/PIK3CD


External links

Nomenclature
HGNC (Hugo)MARCKSL1   7142
Cards
Entrez_Gene (NCBI)MARCKSL1  65108  MARCKS like 1
AliasesF52; MACMARCKS; MLP; MLP1; 
MRP
GeneCards (Weizmann)MARCKSL1
Ensembl hg19 (Hinxton)ENSG00000175130 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175130 [Gene_View]  ENSG00000175130 [Sequence]  chr1:32333829-32336239 [Contig_View]  MARCKSL1 [Vega]
ICGC DataPortalENSG00000175130
TCGA cBioPortalMARCKSL1
AceView (NCBI)MARCKSL1
Genatlas (Paris)MARCKSL1
WikiGenes65108
SOURCE (Princeton)MARCKSL1
Genetics Home Reference (NIH)MARCKSL1
Genomic and cartography
GoldenPath hg38 (UCSC)MARCKSL1  -     chr1:32333829-32336239 -  1p35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARCKSL1  -     1p35.1   [Description]    (hg19-Feb_2009)
EnsemblMARCKSL1 - 1p35.1 [CytoView hg19]  MARCKSL1 - 1p35.1 [CytoView hg38]
Mapping of homologs : NCBIMARCKSL1 [Mapview hg19]  MARCKSL1 [Mapview hg38]
OMIM602940   
Gene and transcription
Genbank (Entrez)AI879076 AL713653 AY007131 BC007904 BC066915
RefSeq transcript (Entrez)NM_023009
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARCKSL1
Cluster EST : UnigeneHs.75061 [ NCBI ]
CGAP (NCI)Hs.75061
Alternative Splicing GalleryENSG00000175130
Gene ExpressionMARCKSL1 [ NCBI-GEO ]   MARCKSL1 [ EBI - ARRAY_EXPRESS ]   MARCKSL1 [ SEEK ]   MARCKSL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCKSL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65108
GTEX Portal (Tissue expression)MARCKSL1
Human Protein AtlasENSG00000175130-MARCKSL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49006   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49006  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49006
Splice isoforms : SwissVarP49006
PhosPhoSitePlusP49006
Domaine pattern : Prosite (Expaxy)MARCKS_1 (PS00826)    MARCKS_2 (PS00827)   
Domains : Interpro (EBI)MARCKS   
Domain families : Pfam (Sanger)MARCKS (PF02063)   
Domain families : Pfam (NCBI)pfam02063   
Conserved Domain (NCBI)MARCKSL1
DMDM Disease mutations65108
Blocks (Seattle)MARCKSL1
SuperfamilyP49006
Human Protein Atlas [tissue]ENSG00000175130-MARCKSL1 [tissue]
Peptide AtlasP49006
HPRD04247
IPIIPI00641181   
Protein Interaction databases
DIP (DOE-UCLA)P49006
IntAct (EBI)P49006
FunCoupENSG00000175130
BioGRIDMARCKSL1
STRING (EMBL)MARCKSL1
ZODIACMARCKSL1
Ontologies - Pathways
QuickGOP49006
Ontology : AmiGOactin binding  protein binding  calmodulin binding  cytoplasm  plasma membrane  positive regulation of cell proliferation  extracellular exosome  
Ontology : EGO-EBIactin binding  protein binding  calmodulin binding  cytoplasm  plasma membrane  positive regulation of cell proliferation  extracellular exosome  
NDEx NetworkMARCKSL1
Atlas of Cancer Signalling NetworkMARCKSL1
Wikipedia pathwaysMARCKSL1
Orthology - Evolution
OrthoDB65108
GeneTree (enSembl)ENSG00000175130
Phylogenetic Trees/Animal Genes : TreeFamMARCKSL1
HOVERGENP49006
HOGENOMP49006
Homologs : HomoloGeneMARCKSL1
Homology/Alignments : Family Browser (UCSC)MARCKSL1
Gene fusions - Rearrangements
Fusion : QuiverMARCKSL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCKSL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCKSL1
dbVarMARCKSL1
ClinVarMARCKSL1
1000_GenomesMARCKSL1 
Exome Variant ServerMARCKSL1
ExAC (Exome Aggregation Consortium)ENSG00000175130
GNOMAD BrowserENSG00000175130
Genetic variants : HAPMAP65108
Genomic Variants (DGV)MARCKSL1 [DGVbeta]
DECIPHERMARCKSL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARCKSL1 
Mutations
ICGC Data PortalMARCKSL1 
TCGA Data PortalMARCKSL1 
Broad Tumor PortalMARCKSL1
OASIS PortalMARCKSL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARCKSL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARCKSL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARCKSL1
DgiDB (Drug Gene Interaction Database)MARCKSL1
DoCM (Curated mutations)MARCKSL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARCKSL1 (select a term)
intoGenMARCKSL1
Cancer3DMARCKSL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602940   
Orphanet
DisGeNETMARCKSL1
MedgenMARCKSL1
Genetic Testing Registry MARCKSL1
NextProtP49006 [Medical]
TSGene65108
GENETestsMARCKSL1
Target ValidationMARCKSL1
Huge Navigator MARCKSL1 [HugePedia]
snp3D : Map Gene to Disease65108
BioCentury BCIQMARCKSL1
ClinGenMARCKSL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65108
Chemical/Pharm GKB GenePA30857
Clinical trialMARCKSL1
Miscellaneous
canSAR (ICR)MARCKSL1 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARCKSL1
EVEXMARCKSL1
GoPubMedMARCKSL1
iHOPMARCKSL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:35:04 CEST 2018

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