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MASTL (microtubule associated serine/threonine kinase like)

Identity

Alias_namesmicrotubule associated serine/threonine kinase-like
Alias_symbol (synonym)FLJ14813
THC2
Gwl
Other aliasGREATWALL
GW
GWL
MAST-L
HGNC (Hugo) MASTL
LocusID (NCBI) 84930
Atlas_Id 43356
Location 10p12.1  [Link to chromosome band 10p12]
Location_base_pair Starts at 27443753 and ends at 27475848 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MASTL   19042
Cards
Entrez_Gene (NCBI)MASTL  84930  microtubule associated serine/threonine kinase like
AliasesGREATWALL; GW; GWL; MAST-L; 
THC2
GeneCards (Weizmann)MASTL
Ensembl hg19 (Hinxton)ENSG00000120539 [Gene_View]  chr10:27443753-27475848 [Contig_View]  MASTL [Vega]
Ensembl hg38 (Hinxton)ENSG00000120539 [Gene_View]  chr10:27443753-27475848 [Contig_View]  MASTL [Vega]
ICGC DataPortalENSG00000120539
TCGA cBioPortalMASTL
AceView (NCBI)MASTL
Genatlas (Paris)MASTL
WikiGenes84930
SOURCE (Princeton)MASTL
Genetics Home Reference (NIH)MASTL
Genomic and cartography
GoldenPath hg19 (UCSC)MASTL  -     chr10:27443753-27475848 +  10p12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MASTL  -     10p12.1   [Description]    (hg38-Dec_2013)
EnsemblMASTL - 10p12.1 [CytoView hg19]  MASTL - 10p12.1 [CytoView hg38]
Mapping of homologs : NCBIMASTL [Mapview hg19]  MASTL [Mapview hg38]
OMIM188000   608221   
Gene and transcription
Genbank (Entrez)AK027719 AK074804 AK123004 AK225319 AW408392
RefSeq transcript (Entrez)NM_001172303 NM_001172304 NM_001320756 NM_001320757 NM_032844
RefSeq genomic (Entrez)NC_000010 NC_018921 NG_016987 NT_008705 NW_004929370
Consensus coding sequences : CCDS (NCBI)MASTL
Cluster EST : UnigeneHs.276905 [ NCBI ]
CGAP (NCI)Hs.276905
Alternative Splicing GalleryENSG00000120539
Gene ExpressionMASTL [ NCBI-GEO ]   MASTL [ EBI - ARRAY_EXPRESS ]   MASTL [ SEEK ]   MASTL [ MEM ]
Gene Expression Viewer (FireBrowse)MASTL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84930
GTEX Portal (Tissue expression)MASTL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GX5
Splice isoforms : SwissVarQ96GX5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96GX5
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TK_X (SM00133)  
Conserved Domain (NCBI)MASTL
DMDM Disease mutations84930
Blocks (Seattle)MASTL
SuperfamilyQ96GX5
Human Protein AtlasENSG00000120539
Peptide AtlasQ96GX5
HPRD10499
IPIIPI00074258   IPI00396230   IPI00550863   
Protein Interaction databases
DIP (DOE-UCLA)Q96GX5
IntAct (EBI)Q96GX5
FunCoupENSG00000120539
BioGRIDMASTL
STRING (EMBL)MASTL
ZODIACMASTL
Ontologies - Pathways
QuickGOQ96GX5
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  centrosome  cellular response to DNA damage stimulus  mitotic nuclear division  female meiosis II  kinase activity  peptidyl-serine phosphorylation  cleavage furrow  negative regulation of protein phosphatase type 2A activity  intracellular signal transduction  cell division  activation of anaphase-promoting complex activity involved in meiotic cell cycle  protein phosphatase 2A binding  regulation of cell cycle  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  centrosome  cellular response to DNA damage stimulus  mitotic nuclear division  female meiosis II  kinase activity  peptidyl-serine phosphorylation  cleavage furrow  negative regulation of protein phosphatase type 2A activity  intracellular signal transduction  cell division  activation of anaphase-promoting complex activity involved in meiotic cell cycle  protein phosphatase 2A binding  regulation of cell cycle  
NDEx NetworkMASTL
Atlas of Cancer Signalling NetworkMASTL
Wikipedia pathwaysMASTL
Orthology - Evolution
OrthoDB84930
GeneTree (enSembl)ENSG00000120539
Phylogenetic Trees/Animal Genes : TreeFamMASTL
HOVERGENQ96GX5
HOGENOMQ96GX5
Homologs : HomoloGeneMASTL
Homology/Alignments : Family Browser (UCSC)MASTL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMASTL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MASTL
dbVarMASTL
ClinVarMASTL
1000_GenomesMASTL 
Exome Variant ServerMASTL
ExAC (Exome Aggregation Consortium)MASTL (select the gene name)
Genetic variants : HAPMAP84930
Genomic Variants (DGV)MASTL [DGVbeta]
DECIPHER (Syndromes)10:27443753-27475848  ENSG00000120539
CONAN: Copy Number AnalysisMASTL 
Mutations
ICGC Data PortalMASTL 
TCGA Data PortalMASTL 
Broad Tumor PortalMASTL
OASIS PortalMASTL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMASTL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMASTL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MASTL
DgiDB (Drug Gene Interaction Database)MASTL
DoCM (Curated mutations)MASTL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MASTL (select a term)
intoGenMASTL
Cancer3DMASTL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188000    608221   
Orphanet17789   
MedgenMASTL
Genetic Testing Registry MASTL
NextProtQ96GX5 [Medical]
TSGene84930
GENETestsMASTL
Huge Navigator MASTL [HugePedia]
snp3D : Map Gene to Disease84930
BioCentury BCIQMASTL
ClinGenMASTL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84930
Chemical/Pharm GKB GenePA134943781
Clinical trialMASTL
Miscellaneous
canSAR (ICR)MASTL (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMASTL
EVEXMASTL
GoPubMedMASTL
iHOPMASTL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:14:36 CET 2017

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