MASTL (microtubule associated serine/threonine kinase like)

2006-10-01  

Identity

HGNC
MASTL
LOCATION
10p12.1
LOCUSID
84930
ALIAS
GREATWALL,GW,GWL,MAST-L,THC2

Other Information

Locus ID:

NCBI: 84930
MIM: 608221
HGNC: 19042
Ensembl: ENSG00000120539

Variants:

dbSNP: 84930
ClinVar: 84930
TCGA: ENSG00000120539
COSMIC: MASTL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120539ENST00000342386Q96GX5
ENSG00000120539ENST00000375940Q96GX5
ENSG00000120539ENST00000375946Q96GX5
ENSG00000120539ENST00000477034A0A087WUU7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
MASTL Facilitates Mitotic ProgressionREACTOMER-HSA-2465910

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208181572010MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis.70
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
214447152011Characterization of the mechanisms controlling Greatwall activity.34
243915102014PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.27
266134072015Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.20
258088372015Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC.19
268727832016PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.18
253737362014Mastl kinase, a promising therapeutic target, promotes cancer recurrence.17
292299932018Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.17
266538552015Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression.14

Citation

Dessen P

MASTL (microtubule associated serine/threonine kinase like)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43356/mastl