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MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase)

Identity

Alias (NCBI)GNT-V
GNT-VA
MGAT5A
glcNAc-T V
HGNC (Hugo) MGAT5
HGNC Alias symbGNT-V
MGAT5A
HGNC Alias namealpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
HGNC Previous namemannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
LocusID (NCBI) 4249
Atlas_Id 41349
Location 2q21.2  [Link to chromosome band 2q21]
Location_base_pair Starts at 134254072 and ends at 134454621 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACVR1C (2q24.1)::MGAT5 (2q21.2)CENPH (5q13.2)::MGAT5 (2q21.2)CYTIP (2q24.1)::MGAT5 (2q21.2)
GPR39 (2q21.2)::MGAT5 (2q21.2)MGAT5 (2q21.2)::GPR39 (2q21.2)MGAT5 (2q21.2)::HNMT (2q22.1)
MGAT5 (2q21.2)::KIF1B (1p36.22)MGAT5 (2q21.2)::MGAT5 (2q21.2)MGAT5 (2q21.2)::MRPL14 (6p21.1)
MGAT5 (2q21.2)::RUNX1T1 (8q21.3)TUG1 (22q12.2)::MGAT5 (2q21.2)CYTIP 2q24.1::MGAT5 2q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(q21;q21) MGAT5::GPR39


External links

 

Nomenclature
HGNC (Hugo)MGAT5   7049
Cards
Entrez_Gene (NCBI)MGAT5    alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
AliasesGNT-V; GNT-VA; MGAT5A; glcNAc-T
GeneCards (Weizmann)MGAT5
Ensembl hg19 (Hinxton)ENSG00000152127 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152127 [Gene_View]  ENSG00000152127 [Sequence]  chr2:134254072-134454621 [Contig_View]  MGAT5 [Vega]
ICGC DataPortalENSG00000152127
TCGA cBioPortalMGAT5
AceView (NCBI)MGAT5
Genatlas (Paris)MGAT5
SOURCE (Princeton)MGAT5
Genetics Home Reference (NIH)MGAT5
Genomic and cartography
GoldenPath hg38 (UCSC)MGAT5  -     chr2:134254072-134454621 +  2q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGAT5  -     2q21.2   [Description]    (hg19-Feb_2009)
GoldenPathMGAT5 - 2q21.2 [CytoView hg19]  MGAT5 - 2q21.2 [CytoView hg38]
ImmunoBaseENSG00000152127
Genome Data Viewer NCBIMGAT5 [Mapview hg19]  
OMIM601774   
Gene and transcription
Genbank (Entrez)AF055029 AF113921 AK056461 AK125207 BC041917
RefSeq transcript (Entrez)NM_001371457 NM_002410
Consensus coding sequences : CCDS (NCBI)MGAT5
Gene ExpressionMGAT5 [ NCBI-GEO ]   MGAT5 [ EBI - ARRAY_EXPRESS ]   MGAT5 [ SEEK ]   MGAT5 [ MEM ]
Gene Expression Viewer (FireBrowse)MGAT5 [ Firebrowse - Broad ]
GenevisibleExpression of MGAT5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4249
GTEX Portal (Tissue expression)MGAT5
Human Protein AtlasENSG00000152127-MGAT5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ09328   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ09328  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ09328
PhosPhoSitePlusQ09328
Domains : Interpro (EBI)DUF4525    GlyclTrfase_18   
Domain families : Pfam (Sanger)DUF4525 (PF15027)    Glyco_transf_18 (PF15024)   
Domain families : Pfam (NCBI)pfam15027    pfam15024   
Conserved Domain (NCBI)MGAT5
PDB (RSDB)5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
PDB Europe5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
PDB (PDBSum)5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
PDB (IMB)5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
Structural Biology KnowledgeBase5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
SCOP (Structural Classification of Proteins)5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
CATH (Classification of proteins structures)5ZIB    5ZIC    6YJQ    6YJR    6YJS    6YJT    6YJU    6YJV   
SuperfamilyQ09328
AlphaFold pdb e-kbQ09328   
Human Protein Atlas [tissue]ENSG00000152127-MGAT5 [tissue]
HPRD03467
Protein Interaction databases
DIP (DOE-UCLA)Q09328
IntAct (EBI)Q09328
BioGRIDMGAT5
STRING (EMBL)MGAT5
ZODIACMGAT5
Ontologies - Pathways
QuickGOQ09328
Ontology : AmiGOGolgi membrane  Golgi membrane  protein phosphatase inhibitor activity  Golgi apparatus  protein N-linked glycosylation  protein N-linked glycosylation  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  viral protein processing  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity  manganese ion binding  positive regulation of cell migration  extracellular exosome  negative regulation of protein tyrosine phosphatase activity  positive regulation of receptor signaling pathway via STAT  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  protein phosphatase inhibitor activity  Golgi apparatus  protein N-linked glycosylation  protein N-linked glycosylation  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  viral protein processing  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity  manganese ion binding  positive regulation of cell migration  extracellular exosome  negative regulation of protein tyrosine phosphatase activity  positive regulation of receptor signaling pathway via STAT  
Pathways : KEGGN-Glycan biosynthesis   
NDEx NetworkMGAT5
Atlas of Cancer Signalling NetworkMGAT5
Wikipedia pathwaysMGAT5
Orthology - Evolution
OrthoDB4249
GeneTree (enSembl)ENSG00000152127
Phylogenetic Trees/Animal Genes : TreeFamMGAT5
Homologs : HomoloGeneMGAT5
Homology/Alignments : Family Browser (UCSC)MGAT5
Gene fusions - Rearrangements
Fusion : MitelmanACVR1C::MGAT5 [2q24.1/2q21.2]  
Fusion : MitelmanCYTIP::MGAT5 [2q24.1/2q21.2]  
Fusion : MitelmanGPR39::MGAT5 [2q21.2/2q21.2]  
Fusion : MitelmanMGAT5::GPR39 [2q21.2/2q21.2]  
Fusion : MitelmanMGAT5::HNMT [2q21.2/2q22.1]  
Fusion : QuiverMGAT5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGAT5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGAT5
dbVarMGAT5
ClinVarMGAT5
MonarchMGAT5
1000_GenomesMGAT5 
Exome Variant ServerMGAT5
GNOMAD BrowserENSG00000152127
Varsome BrowserMGAT5
ACMGMGAT5 variants
VarityQ09328
Genomic Variants (DGV)MGAT5 [DGVbeta]
DECIPHERMGAT5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGAT5 
Mutations
ICGC Data PortalMGAT5 
TCGA Data PortalMGAT5 
Broad Tumor PortalMGAT5
OASIS PortalMGAT5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGAT5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMGAT5
Mutations and Diseases : HGMDMGAT5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMGAT5
DgiDB (Drug Gene Interaction Database)MGAT5
DoCM (Curated mutations)MGAT5
CIViC (Clinical Interpretations of Variants in Cancer)MGAT5
Cancer3DMGAT5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601774   
Orphanet
DisGeNETMGAT5
MedgenMGAT5
Genetic Testing Registry MGAT5
NextProtQ09328 [Medical]
GENETestsMGAT5
Target ValidationMGAT5
Huge Navigator MGAT5 [HugePedia]
ClinGenMGAT5
Clinical trials, drugs, therapy
MyCancerGenomeMGAT5
Protein Interactions : CTDMGAT5
Pharm GKB GenePA30784
PharosQ09328
Clinical trialMGAT5
Miscellaneous
canSAR (ICR)MGAT5
HarmonizomeMGAT5
ARCHS4MGAT5
DataMed IndexMGAT5
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMGAT5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:20:20 CET 2022

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