Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MGMT (O-6-methylguanine-DNA methyltransferase)

Identity

Other alias-
HGNC (Hugo) MGMT
LocusID (NCBI) 4255
Atlas_Id 416
Location 10q26.3  [Link to chromosome band 10q26]
Location_base_pair Starts at 129467184 and ends at 129767620 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTNNA3 (10q21.3) / MGMT (10q26.3)DOCK1 (10q26.2) / MGMT (10q26.3)MGMT (10q26.3) / LGI4 (19q13.12)
MGMT (10q26.3) / MGMT (10q26.3)MGMT (10q26.3) / NBPF14 (1q21.2)PRRC2B (9q34.13) / MGMT (10q26.3)
ZSCAN29 (15q15.3) / MGMT (10q26.3)CTNNA3 10q21.3 / MGMT 10q26.3DOCK1 10q26.2 / MGMT 10q26.3
MGMT 10q26.3 / LGI4 19q13.12ZSCAN29 15q15.3 / MGMT 10q26.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma
Nervous System: Glioma: an overview
Head and Neck: Epidermoid carcinoma
Head and Neck: Oral leukoplakia


External links

Nomenclature
HGNC (Hugo)MGMT   7059
Cards
Entrez_Gene (NCBI)MGMT  4255  O-6-methylguanine-DNA methyltransferase
Aliases
GeneCards (Weizmann)MGMT
Ensembl hg19 (Hinxton)ENSG00000170430 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170430 [Gene_View]  chr10:129467184-129767620 [Contig_View]  MGMT [Vega]
ICGC DataPortalENSG00000170430
TCGA cBioPortalMGMT
AceView (NCBI)MGMT
Genatlas (Paris)MGMT
WikiGenes4255
SOURCE (Princeton)MGMT
Genetics Home Reference (NIH)MGMT
Genomic and cartography
GoldenPath hg38 (UCSC)MGMT  -     chr10:129467184-129767620 +  10q26.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGMT  -     10q26.3   [Description]    (hg19-Feb_2009)
EnsemblMGMT - 10q26.3 [CytoView hg19]  MGMT - 10q26.3 [CytoView hg38]
Mapping of homologs : NCBIMGMT [Mapview hg19]  MGMT [Mapview hg38]
OMIM156569   
Gene and transcription
Genbank (Entrez)AK293593 BC000824 BI520029 BT006714 DC387686
RefSeq transcript (Entrez)NM_002412
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MGMT
Cluster EST : UnigeneHs.501522 [ NCBI ]
CGAP (NCI)Hs.501522
Alternative Splicing GalleryENSG00000170430
Gene ExpressionMGMT [ NCBI-GEO ]   MGMT [ EBI - ARRAY_EXPRESS ]   MGMT [ SEEK ]   MGMT [ MEM ]
Gene Expression Viewer (FireBrowse)MGMT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4255
GTEX Portal (Tissue expression)MGMT
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16455   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16455  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16455
Splice isoforms : SwissVarP16455
Catalytic activity : Enzyme2.1.1.63 [ Enzyme-Expasy ]   2.1.1.632.1.1.63 [ IntEnz-EBI ]   2.1.1.63 [ BRENDA ]   2.1.1.63 [ KEGG ]   
PhosPhoSitePlusP16455
Domaine pattern : Prosite (Expaxy)MGMT (PS00374)   
Domains : Interpro (EBI)MethylDNA_cys_MeTrfase_AS    MethylDNA_cys_MeTrfase_DNA-bd    MethylG_MeTrfase_N    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DNA_binding_1 (PF01035)    Methyltransf_1N (PF02870)   
Domain families : Pfam (NCBI)pfam01035    pfam02870   
Conserved Domain (NCBI)MGMT
DMDM Disease mutations4255
Blocks (Seattle)MGMT
PDB (SRS)1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
PDB (PDBSum)1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
PDB (IMB)1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
PDB (RSDB)1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
Structural Biology KnowledgeBase1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
SCOP (Structural Classification of Proteins)1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
CATH (Classification of proteins structures)1EH6    1EH7    1EH8    1QNT    1T38    1T39    1YFH   
SuperfamilyP16455
Human Protein AtlasENSG00000170430
Peptide AtlasP16455
HPRD01135
IPIIPI00028618   
Protein Interaction databases
DIP (DOE-UCLA)P16455
IntAct (EBI)P16455
FunCoupENSG00000170430
BioGRIDMGMT
STRING (EMBL)MGMT
ZODIACMGMT
Ontologies - Pathways
QuickGOP16455
Ontology : AmiGODNA binding  methylated-DNA-[protein]-cysteine S-methyltransferase activity  calcium ion binding  nucleus  nucleoplasm  nucleoplasm  DNA ligation  DNA methylation  DNA dealkylation involved in DNA repair  methyltransferase activity  DNA-methyltransferase activity  response to toxic substance  membrane  cellular response to oxidative stress  response to drug  negative regulation of apoptotic process  regulation of cysteine-type endopeptidase activity involved in apoptotic process  response to ethanol  response to folic acid  mammary gland epithelial cell differentiation  cellular response to organic cyclic compound  cellular response to ionizing radiation  positive regulation of double-strand break repair  
Ontology : EGO-EBIDNA binding  methylated-DNA-[protein]-cysteine S-methyltransferase activity  calcium ion binding  nucleus  nucleoplasm  nucleoplasm  DNA ligation  DNA methylation  DNA dealkylation involved in DNA repair  methyltransferase activity  DNA-methyltransferase activity  response to toxic substance  membrane  cellular response to oxidative stress  response to drug  negative regulation of apoptotic process  regulation of cysteine-type endopeptidase activity involved in apoptotic process  response to ethanol  response to folic acid  mammary gland epithelial cell differentiation  cellular response to organic cyclic compound  cellular response to ionizing radiation  positive regulation of double-strand break repair  
NDEx NetworkMGMT
Atlas of Cancer Signalling NetworkMGMT
Wikipedia pathwaysMGMT
Orthology - Evolution
OrthoDB4255
GeneTree (enSembl)ENSG00000170430
Phylogenetic Trees/Animal Genes : TreeFamMGMT
HOVERGENP16455
HOGENOMP16455
Homologs : HomoloGeneMGMT
Homology/Alignments : Family Browser (UCSC)MGMT
Gene fusions - Rearrangements
Fusion : MitelmanCTNNA3/MGMT [10q21.3/10q26.3]  [t(10;10)(q21;q26)]  
Fusion : MitelmanDOCK1/MGMT [10q26.2/10q26.3]  [t(10;10)(q26;q26)]  
Fusion : MitelmanMGMT/LGI4 [10q26.3/19q13.12]  [t(10;19)(q26;q13)]  
Fusion : MitelmanPRRC2B/MGMT [9q34.13/10q26.3]  [t(9;10)(q34;q26)]  
Fusion : MitelmanZSCAN29/MGMT [15q15.3/10q26.3]  [t(10;15)(q26;q15)]  
Fusion: TCGACTNNA3 10q21.3 MGMT 10q26.3 BRCA
Fusion: TCGADOCK1 10q26.2 MGMT 10q26.3 BRCA
Fusion: TCGAMGMT 10q26.3 LGI4 19q13.12 BRCA
Fusion: TCGAZSCAN29 15q15.3 MGMT 10q26.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGMT
dbVarMGMT
ClinVarMGMT
1000_GenomesMGMT 
Exome Variant ServerMGMT
ExAC (Exome Aggregation Consortium)MGMT (select the gene name)
Genetic variants : HAPMAP4255
Genomic Variants (DGV)MGMT [DGVbeta]
DECIPHERMGMT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGMT 
Mutations
ICGC Data PortalMGMT 
TCGA Data PortalMGMT 
Broad Tumor PortalMGMT
OASIS PortalMGMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGMT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMGMT
intOGen PortalMGMT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MGMT
DgiDB (Drug Gene Interaction Database)MGMT
DoCM (Curated mutations)MGMT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MGMT (select a term)
intoGenMGMT
Cancer3DMGMT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM156569   
Orphanet19649    19650    3560   
MedgenMGMT
Genetic Testing Registry MGMT
NextProtP16455 [Medical]
TSGene4255
GENETestsMGMT
Target ValidationMGMT
Huge Navigator MGMT [HugePedia]
snp3D : Map Gene to Disease4255
BioCentury BCIQMGMT
ClinGenMGMT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4255
Chemical/Pharm GKB GenePA239
Clinical trialMGMT
Miscellaneous
canSAR (ICR)MGMT (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMGMT
EVEXMGMT
GoPubMedMGMT
iHOPMGMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:17:58 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.