MMP13 (matrix metallopeptidase 13)

2003-02-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CLG3,MANDP1,MDST,MMP-13
FUSION GENES

Other Information

Locus ID:

NCBI: 4322
MIM: 600108
HGNC: 7159
Ensembl: ENSG00000137745

Variants:

dbSNP: 4322
ClinVar: 4322
TCGA: ENSG00000137745
COSMIC: MMP13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137745ENST00000260302P45452
ENSG00000137745ENST00000340273G5E971
ENSG00000137745ENST00000615555Q7Z5M0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170092602006Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice.220
201312572010MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes.106
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
194943182009Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.82
173119292007Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes.77
128781722003Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes.76
120093312002Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.75
199480512009Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.74
169481162006Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.68
121394412002The structure, regulation, and function of human matrix metalloproteinase-13.66

Citation

Dessen P

MMP13 (matrix metallopeptidase 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41390/mmp13