MPO (myeloperoxidase)

2007-02-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 4353
MIM: 606989
HGNC: 7218
Ensembl: ENSG00000005381

Variants:

dbSNP: 4353
ClinVar: 4353
TCGA: ENSG00000005381
COSMIC: MPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005381ENST00000225275P05164
ENSG00000005381ENST00000577220J3QSF7

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443297AgranulocytosisDiseaseVariantAnnotationnot associatedPD27168101
PA445113NeutropeniaDiseaseVariantAnnotationnot associatedPD27168101
PA449061clozapineChemicalVariantAnnotationnot associatedPD27168101

References

Pubmed IDYearTitleCitations
209748162010Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps.448
129528352003Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes.183
209746722011Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity.175
120894422002Myeloperoxidase, a leukocyte-derived vascular NO oxidase.149
230661642013Myeloperoxidase: a front-line defender against phagocytosed microorganisms.136
203641352010Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation.126
228024472012Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus.124
242912812014Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854462006A testing framework for identifying susceptibility genes in the presence of epistasis.81

Citation

Dessen P

MPO (myeloperoxidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43627/mpo