Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MRC2 (mannose receptor C type 2)

Identity

Alias_namesmannose receptor
Alias_symbol (synonym)KIAA0709
ENDO180
CLEC13E
CD280
Other aliasUPARAP
HGNC (Hugo) MRC2
LocusID (NCBI) 9902
Atlas_Id 47622
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 62627401 and ends at 62693601 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYTH1 (17q25.3) / MRC2 (17q23.2)MRC2 (17q23.2) / GNA12 (7p22.3)MRC2 (17q23.2) / LRRC37A3 (17q24.1)
MRC2 (17q23.2) / MAP3K3 (17q23.3)MRC2 (17q23.2) / MRC2 (17q23.2)MRC2 (17q23.2) / PHYHIPL (10q21.1)
MRC2 (17q23.2) / RND2 (17q21.31)MRC2 (17q23.2) / RNF20 (9q31.1)MRC2 (17q23.2) / SECISBP2 (9q22.2)
MRC2 (17q23.2) / YBX3 (12p13.2)CYTH1 17q25.3 / MRC2 17q23.2MRC2 17q23.2 / PHYHIPL 10q21.1
MRC2 17q23.2 / RND2 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(10;17)(q21;q23) MRC2/PHYHIPL
t(17;17)(q21;q23) MRC2/RND2
t(17;17)(q23;q25) CYTH1/MRC2

External links

Nomenclature
HGNC (Hugo)MRC2   16875
Cards
Entrez_Gene (NCBI)MRC2  9902  mannose receptor C type 2
AliasesCD280; CLEC13E; ENDO180; UPARAP
GeneCards (Weizmann)MRC2
Ensembl hg19 (Hinxton)ENSG00000011028 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011028 [Gene_View]  ENSG00000011028 [Sequence]  chr17:62627401-62693601 [Contig_View]  MRC2 [Vega]
ICGC DataPortalENSG00000011028
TCGA cBioPortalMRC2
AceView (NCBI)MRC2
Genatlas (Paris)MRC2
WikiGenes9902
SOURCE (Princeton)MRC2
Genetics Home Reference (NIH)MRC2
Genomic and cartography
GoldenPath hg38 (UCSC)MRC2  -     chr17:62627401-62693601 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRC2  -     17q23.2   [Description]    (hg19-Feb_2009)
EnsemblMRC2 - 17q23.2 [CytoView hg19]  MRC2 - 17q23.2 [CytoView hg38]
Mapping of homologs : NCBIMRC2 [Mapview hg19]  MRC2 [Mapview hg38]
OMIM612264   
Gene and transcription
Genbank (Entrez)AB014609 AF107292 AF134838 AI458446 AK093230
RefSeq transcript (Entrez)NM_006039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MRC2
Cluster EST : UnigeneHs.7835 [ NCBI ]
CGAP (NCI)Hs.7835
Alternative Splicing GalleryENSG00000011028
Gene ExpressionMRC2 [ NCBI-GEO ]   MRC2 [ EBI - ARRAY_EXPRESS ]   MRC2 [ SEEK ]   MRC2 [ MEM ]
Gene Expression Viewer (FireBrowse)MRC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9902
GTEX Portal (Tissue expression)MRC2
Human Protein AtlasENSG00000011028-MRC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBG0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBG0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBG0
Splice isoforms : SwissVarQ9UBG0
PhosPhoSitePlusQ9UBG0
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)    FN2_1 (PS00023)    FN2_2 (PS51092)    RICIN_B_LECTIN (PS50231)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    C-type_lectin_CS    CD209-like_CTLD    CTDL_fold    FN_type2_dom    FN_type2_sf    Kringle-like    Ricin_B-like_lectins    Ricin_B_lectin   
Domain families : Pfam (Sanger)fn2 (PF00040)    Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00040    pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  FN2 (SM00059)  RICIN (SM00458)  
Conserved Domain (NCBI)MRC2
DMDM Disease mutations9902
Blocks (Seattle)MRC2
PDB (RSDB)5AO5    5AO6    5E4K    5E4L    5EW6   
PDB Europe5AO5    5AO6    5E4K    5E4L    5EW6   
PDB (PDBSum)5AO5    5AO6    5E4K    5E4L    5EW6   
PDB (IMB)5AO5    5AO6    5E4K    5E4L    5EW6   
Structural Biology KnowledgeBase5AO5    5AO6    5E4K    5E4L    5EW6   
SCOP (Structural Classification of Proteins)5AO5    5AO6    5E4K    5E4L    5EW6   
CATH (Classification of proteins structures)5AO5    5AO6    5E4K    5E4L    5EW6   
SuperfamilyQ9UBG0
Human Protein Atlas [tissue]ENSG00000011028-MRC2 [tissue]
Peptide AtlasQ9UBG0
HPRD10094
IPIIPI00005707   IPI00902949   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBG0
IntAct (EBI)Q9UBG0
FunCoupENSG00000011028
BioGRIDMRC2
STRING (EMBL)MRC2
ZODIACMRC2
Ontologies - Pathways
QuickGOQ9UBG0
Ontology : AmiGOosteoblast differentiation  transmembrane signaling receptor activity  protein binding  collagen binding  focal adhesion  endocytosis  membrane  integral component of membrane  carbohydrate binding  collagen catabolic process  
Ontology : EGO-EBIosteoblast differentiation  transmembrane signaling receptor activity  protein binding  collagen binding  focal adhesion  endocytosis  membrane  integral component of membrane  carbohydrate binding  collagen catabolic process  
Pathways : KEGGPhagosome    Tuberculosis   
NDEx NetworkMRC2
Atlas of Cancer Signalling NetworkMRC2
Wikipedia pathwaysMRC2
Orthology - Evolution
OrthoDB9902
GeneTree (enSembl)ENSG00000011028
Phylogenetic Trees/Animal Genes : TreeFamMRC2
HOGENOMQ9UBG0
Homologs : HomoloGeneMRC2
Homology/Alignments : Family Browser (UCSC)MRC2
Gene fusions - Rearrangements
Fusion : MitelmanCYTH1/MRC2 [17q25.3/17q23.2]  [t(17;17)(q23;q25)]  
Fusion : MitelmanMRC2/PHYHIPL [17q23.2/10q21.1]  [t(10;17)(q21;q23)]  
Fusion : MitelmanMRC2/RND2 [17q23.2/17q21.31]  [t(17;17)(q21;q23)]  
Fusion PortalCYTH1 17q25.3 MRC2 17q23.2 BRCA
Fusion PortalMRC2 17q23.2 PHYHIPL 10q21.1 PRAD
Fusion PortalMRC2 17q23.2 RND2 17q21.31 GBM
Fusion : QuiverMRC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRC2
dbVarMRC2
ClinVarMRC2
1000_GenomesMRC2 
Exome Variant ServerMRC2
ExAC (Exome Aggregation Consortium)ENSG00000011028
GNOMAD BrowserENSG00000011028
Varsome BrowserMRC2
Genetic variants : HAPMAP9902
Genomic Variants (DGV)MRC2 [DGVbeta]
DECIPHERMRC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRC2 
Mutations
ICGC Data PortalMRC2 
TCGA Data PortalMRC2 
Broad Tumor PortalMRC2
OASIS PortalMRC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MRC2
DgiDB (Drug Gene Interaction Database)MRC2
DoCM (Curated mutations)MRC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRC2 (select a term)
intoGenMRC2
Cancer3DMRC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612264   
Orphanet
DisGeNETMRC2
MedgenMRC2
Genetic Testing Registry MRC2
NextProtQ9UBG0 [Medical]
TSGene9902
GENETestsMRC2
Target ValidationMRC2
Huge Navigator MRC2 [HugePedia]
snp3D : Map Gene to Disease9902
BioCentury BCIQMRC2
ClinGenMRC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9902
Chemical/Pharm GKB GenePA134988161
Clinical trialMRC2
Miscellaneous
canSAR (ICR)MRC2 (select the gene name)
DataMed IndexMRC2
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRC2
EVEXMRC2
GoPubMedMRC2
iHOPMRC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:26:01 CET 2019
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