MRC2 (mannose receptor C type 2)

2007-07-01  

Identity

HGNC
LOCATION
17q23.2
LOCUSID
ALIAS
CD280,CLEC13E,ENDO180,UPARAP
FUSION GENES

Other Information

Locus ID:

NCBI: 9902
MIM: 612264
HGNC: 16875
Ensembl: ENSG00000011028

Variants:

dbSNP: 9902
ClinVar: 9902
TCGA: ENSG00000011028
COSMIC: MRC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011028ENST00000303375Q9UBG0
ENSG00000011028ENST00000446119E7EME3
ENSG00000011028ENST00000579432J3QQZ6
ENSG00000011028ENST00000584682J3KRF1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Cross-presentation of soluble exogenous antigens (endosomes)REACTOMER-HSA-1236978

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126459472003Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages.80
203395552010A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.70
126686562003uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.59
122441462002Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages.48
129725492003Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor.43
195840752009Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.36
179749642007The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.26
198615002009Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.24
129529332003GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis.21
171895242007Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer.21

Citation

Dessen P

MRC2 (mannose receptor C type 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47622/mrc2