Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MRC2 (mannose receptor C type 2)

Identity

Alias (NCBI)CD280
CLEC13E
ENDO180
UPARAP
HGNC (Hugo) MRC2
HGNC Alias symbKIAA0709
ENDO180
CLEC13E
CD280
HGNC Alias nameC-type lectin domain family 13 member E
 endocytic receptor 180
HGNC Previous namemannose receptor, C type 2
LocusID (NCBI) 9902
Atlas_Id 47622
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 62627670 and ends at 62693597 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYTH1 (17q25.3) / MRC2 (17q23.2)MRC2 (17q23.2) / GNA12 (7p22.3)MRC2 (17q23.2) / LRRC37A3 (17q24.1)
MRC2 (17q23.2) / MAP3K3 (17q23.3)MRC2 (17q23.2) / MRC2 (17q23.2)MRC2 (17q23.2) / PHYHIPL (10q21.1)
MRC2 (17q23.2) / RND2 (17q21.31)MRC2 (17q23.2) / RNF20 (9q31.1)MRC2 (17q23.2) / SECISBP2 (9q22.2)
MRC2 (17q23.2) / YBX3 (12p13.2)CYTH1 17q25.3 / MRC2 17q23.2MRC2 17q23.2 / PHYHIPL 10q21.1
MRC2 17q23.2 / RND2 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)MRC2   16875
Cards
Entrez_Gene (NCBI)MRC2    mannose receptor C type 2
AliasesCD280; CLEC13E; ENDO180; UPARAP
GeneCards (Weizmann)MRC2
Ensembl hg19 (Hinxton)ENSG00000011028 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011028 [Gene_View]  ENSG00000011028 [Sequence]  chr17:62627670-62693597 [Contig_View]  MRC2 [Vega]
ICGC DataPortalENSG00000011028
TCGA cBioPortalMRC2
AceView (NCBI)MRC2
Genatlas (Paris)MRC2
SOURCE (Princeton)MRC2
Genetics Home Reference (NIH)MRC2
Genomic and cartography
GoldenPath hg38 (UCSC)MRC2  -     chr17:62627670-62693597 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRC2  -     17q23.2   [Description]    (hg19-Feb_2009)
GoldenPathMRC2 - 17q23.2 [CytoView hg19]  MRC2 - 17q23.2 [CytoView hg38]
ImmunoBaseENSG00000011028
Genome Data Viewer NCBIMRC2 [Mapview hg19]  
OMIM612264   
Gene and transcription
Genbank (Entrez)AB014609 AF107292 AF134838 AI458446 AK093230
RefSeq transcript (Entrez)NM_006039
Consensus coding sequences : CCDS (NCBI)MRC2
Gene ExpressionMRC2 [ NCBI-GEO ]   MRC2 [ EBI - ARRAY_EXPRESS ]   MRC2 [ SEEK ]   MRC2 [ MEM ]
Gene Expression Viewer (FireBrowse)MRC2 [ Firebrowse - Broad ]
GenevisibleExpression of MRC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9902
GTEX Portal (Tissue expression)MRC2
Human Protein AtlasENSG00000011028-MRC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBG0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBG0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBG0
PhosPhoSitePlusQ9UBG0
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)    FN2_1 (PS00023)    FN2_2 (PS51092)    RICIN_B_LECTIN (PS50231)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link_sf    C-type_lectin_CS    CD209-like_CTLD    CTDL_fold    FN_type2_dom    FN_type2_sf    Kringle-like    Ricin_B-like_lectins    Ricin_B_lectin   
Domain families : Pfam (Sanger)fn2 (PF00040)    Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00040    pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  FN2 (SM00059)  RICIN (SM00458)  
Conserved Domain (NCBI)MRC2
PDB (RSDB)5AO5    5AO6    5E4K    5E4L    5EW6   
PDB Europe5AO5    5AO6    5E4K    5E4L    5EW6   
PDB (PDBSum)5AO5    5AO6    5E4K    5E4L    5EW6   
PDB (IMB)5AO5    5AO6    5E4K    5E4L    5EW6   
Structural Biology KnowledgeBase5AO5    5AO6    5E4K    5E4L    5EW6   
SCOP (Structural Classification of Proteins)5AO5    5AO6    5E4K    5E4L    5EW6   
CATH (Classification of proteins structures)5AO5    5AO6    5E4K    5E4L    5EW6   
SuperfamilyQ9UBG0
AlphaFold pdb e-kbQ9UBG0   
Human Protein Atlas [tissue]ENSG00000011028-MRC2 [tissue]
HPRD10094
Protein Interaction databases
DIP (DOE-UCLA)Q9UBG0
IntAct (EBI)Q9UBG0
BioGRIDMRC2
STRING (EMBL)MRC2
ZODIACMRC2
Ontologies - Pathways
QuickGOQ9UBG0
Ontology : AmiGOosteoblast differentiation  protein binding  collagen binding  focal adhesion  endocytosis  membrane  integral component of membrane  carbohydrate binding  collagen catabolic process  signaling receptor activity  
Ontology : EGO-EBIosteoblast differentiation  protein binding  collagen binding  focal adhesion  endocytosis  membrane  integral component of membrane  carbohydrate binding  collagen catabolic process  signaling receptor activity  
Pathways : KEGGPhagosome    Tuberculosis   
NDEx NetworkMRC2
Atlas of Cancer Signalling NetworkMRC2
Wikipedia pathwaysMRC2
Orthology - Evolution
OrthoDB9902
GeneTree (enSembl)ENSG00000011028
Phylogenetic Trees/Animal Genes : TreeFamMRC2
Homologs : HomoloGeneMRC2
Homology/Alignments : Family Browser (UCSC)MRC2
Gene fusions - Rearrangements
Fusion : MitelmanCYTH1/MRC2 [17q25.3/17q23.2]  
Fusion : MitelmanMRC2/PHYHIPL [17q23.2/10q21.1]  
Fusion : MitelmanMRC2/RND2 [17q23.2/17q21.31]  
Fusion : QuiverMRC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRC2
dbVarMRC2
ClinVarMRC2
MonarchMRC2
1000_GenomesMRC2 
Exome Variant ServerMRC2
GNOMAD BrowserENSG00000011028
Varsome BrowserMRC2
ACMGMRC2 variants
VarityQ9UBG0
Genomic Variants (DGV)MRC2 [DGVbeta]
DECIPHERMRC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRC2 
Mutations
ICGC Data PortalMRC2 
TCGA Data PortalMRC2 
Broad Tumor PortalMRC2
OASIS PortalMRC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMRC2
Mutations and Diseases : HGMDMRC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMRC2
DgiDB (Drug Gene Interaction Database)MRC2
DoCM (Curated mutations)MRC2
CIViC (Clinical Interpretations of Variants in Cancer)MRC2
Cancer3DMRC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612264   
Orphanet
DisGeNETMRC2
MedgenMRC2
Genetic Testing Registry MRC2
NextProtQ9UBG0 [Medical]
GENETestsMRC2
Target ValidationMRC2
Huge Navigator MRC2 [HugePedia]
ClinGenMRC2
Clinical trials, drugs, therapy
MyCancerGenomeMRC2
Protein Interactions : CTDMRC2
Pharm GKB GenePA134988161
PharosQ9UBG0
Clinical trialMRC2
Miscellaneous
canSAR (ICR)MRC2
HarmonizomeMRC2
DataMed IndexMRC2
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMRC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:14 CEST 2021
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