NAE1 (NEDD8 activating enzyme E1 subunit 1)

2010-04-01  

Identity

HGNC
NAE1
LOCATION
16q22.1
LOCUSID
8883
ALIAS
A-116A10.1,APPBP1,HPP1,ula-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8883
MIM: 603385
HGNC: 621
Ensembl: ENSG00000159593

Variants:

dbSNP: 8883
ClinVar: 8883
TCGA: ENSG00000159593
COSMIC: NAE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159593ENST00000290810Q13564
ENSG00000159593ENST00000359087Q13564
ENSG00000159593ENST00000379463Q13564
ENSG00000159593ENST00000394074Q13564
ENSG00000159593ENST00000561579J3QRA5
ENSG00000159593ENST00000562428J3QLH4
ENSG00000159593ENST00000563185H3BMR3
ENSG00000159593ENST00000563253H3BMN8
ENSG00000159593ENST00000565535H3BQW6
ENSG00000159593ENST00000566336J3KRK3
ENSG00000159593ENST00000566663J3KTE3
ENSG00000159593ENST00000567743H3BQ16
ENSG00000159593ENST00000569348H3BS69
ENSG00000159593ENST00000569388H3BSS8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146905972003The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.89
126469242003Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.75
197954562010Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma.63
127403882003Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.41
252298382014Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target.24
186277662008TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.15
292339052018Neddylation Blockade Diminishes Hepatic Metastasis by Dampening Cancer Stem-Like Cells and Angiogenesis in Uveal Melanoma.12
211519962010Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells.7
231853682012A metal-based inhibitor of NEDD8-activating enzyme.6
285354532017Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine.5

Citation

Dessen P

NAE1 (NEDD8 activating enzyme E1 subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51436/nae1