NFIB (nuclear factor I B)

2003-02-01  

Identity

HGNC
LOCATION
9p23
LOCUSID
ALIAS
CTF,HMGIC/NFIB,MACID,NF-I/B,NF1-B,NFI-B,NFI-RED,NFIB2,NFIB3
FUSION GENES

Other Information

Locus ID:

NCBI: 4781
MIM: 600728
HGNC: 7785
Ensembl: ENSG00000147862

Variants:

dbSNP: 4781
ClinVar: 4781
TCGA: ENSG00000147862
COSMIC: NFIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147862ENST00000380921Q5W0Y9
ENSG00000147862ENST00000380924Q5VW31
ENSG00000147862ENST00000380934A0A0A0MRX8
ENSG00000147862ENST00000380953O00712
ENSG00000147862ENST00000380959O00712
ENSG00000147862ENST00000380959Q5VW28
ENSG00000147862ENST00000397575Q5VW30
ENSG00000147862ENST00000397579Q5VW27
ENSG00000147862ENST00000397581Q5VW26
ENSG00000147862ENST00000493697U3KPY9
ENSG00000147862ENST00000543693O00712
ENSG00000147862ENST00000606230U3KQE8
ENSG00000147862ENST00000622520A0A087WXP2
ENSG00000147862ENST00000635877A0A1B0GWI9
ENSG00000147862ENST00000636057A0A1B0GW37
ENSG00000147862ENST00000636063A0A1B0GTC1
ENSG00000147862ENST00000636432A0A1B0GVN4
ENSG00000147862ENST00000636735A0A1B0GWB8
ENSG00000147862ENST00000637640A0A1B0GU97
ENSG00000147862ENST00000637742A0A1B0GWJ4
ENSG00000147862ENST00000646622A0A2R8Y7V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotation, VariantAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotation, VariantAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
198412622009Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck.190
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
207026102010Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance.67
217648512011Nuclear factor I/B is an oncogene in small cell lung cancer.62
216080072011MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B.45
266316092016Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations.44
260848012015A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.34
225053522012Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.32
219765422011Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome.31
273731562016Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.29

Citation

Dessen P

NFIB (nuclear factor I B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/253/nfib