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NFIB (nuclear factor I B)

Identity

Other namesCTF
HMGIC/NFIB
NF-I/B
NF1-B
NFI-B
NFI-RED
NFIB2
NFIB3
HGNC (Hugo) NFIB
LocusID (NCBI) 4781
Atlas_Id 253
Location 9p23
Location_base_pair Starts at 14081842 and ends at 14314045 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HMGA2 (12q14.3) / NFIB (9p23)MPDZ (9p23) / NFIB (9p23)MYB (6q23.3) / NFIB (9p23)
NFIB (9p23) / AIG1 (6q24.2)NFIB (9p23) / ERBB4 (2q34)NFIB (9p23) / FREM1 (9p22.3)
NFIB (9p23) / HEATR5B (2p22.2)NFIB (9p23) / HMGA2 (12q14.3)NFIB (9p23) / KIF13B (8p12)
NFIB (9p23) / MAN1A1 (6q22.31)NFIB (9p23) / MYB (6q23.3)NFIB (9p23) / NFIB (9p23)
NFIB (9p23) / SREK1 (5q12.3)NFIB (9p23) / STRN (2p22.2)NFIB (9p23) / ZDHHC21 (9p22.3)
NFIB 9p23 / MYB 6q23.3MPDZ 9p23 / NFIB 9p23MYB 6q23.3 / NFIB 9p23
NFIB 9p23 / FREM1 9p22.3NFIB 9p23 / HEATR5B 2p22.2NFIB 9p23 / STRN 2p22.2
NFIB 9p23 / ZDHHC21 9p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Breast: Ductal carcinoma
Soft Tissues: Lipoma / benign lipomatous tumors
Soft Tissues: Ordinary lipoma with t(1;12)(p32;q14) HMGA2/PPAP2B
Head and Neck: Salivary gland tumors: an overview
Skin: Cylindroma
Soft tissue tumors: an overview

External links

Nomenclature
HGNC (Hugo)NFIB   7785
Cards
Entrez_Gene (NCBI)NFIB  4781  nuclear factor I B
GeneCards (Weizmann)NFIB
Ensembl hg19 (Hinxton)ENSG00000147862 [Gene_View]  chr9:14081842-14314045 [Contig_View]  NFIB [Vega]
Ensembl hg38 (Hinxton)ENSG00000147862 [Gene_View]  chr9:14081842-14314045 [Contig_View]  NFIB [Vega]
ICGC DataPortalENSG00000147862
TCGA cBioPortalNFIB
AceView (NCBI)NFIB
Genatlas (Paris)NFIB
WikiGenes4781
SOURCE (Princeton)NFIB
Genomic and cartography
GoldenPath hg19 (UCSC)NFIB  -     chr9:14081842-14314045 -  9p23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NFIB  -     9p23   [Description]    (hg38-Dec_2013)
EnsemblNFIB - 9p23 [CytoView hg19]  NFIB - 9p23 [CytoView hg38]
Mapping of homologs : NCBINFIB [Mapview hg19]  NFIB [Mapview hg38]
OMIM600728   
Gene and transcription
Genbank (Entrez)AF022215 AI140312 AK094066 AK129782 AK131233
RefSeq transcript (Entrez)NM_001190737 NM_001190738 NM_001282787 NM_005596
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)NFIB
Cluster EST : UnigeneHs.644095 [ NCBI ]
CGAP (NCI)Hs.644095
Alternative Splicing : Fast-db (Paris)GSHG0030671
Alternative Splicing GalleryENSG00000147862
Gene ExpressionNFIB [ NCBI-GEO ]   NFIB [ EBI - ARRAY_EXPRESS ]   NFIB [ SEEK ]   NFIB [ MEM ]
Gene Expression Viewer (FireBrowse)NFIB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4781
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00712 (Uniprot)
NextProtO00712  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00712
Splice isoforms : SwissVarO00712 (Swissvar)
PhosPhoSitePlusO00712
Domaine pattern : Prosite (Expaxy)CTF_NFI_1 (PS00349)    CTF_NFI_2 (PS51080)   
Domains : Interpro (EBI)CTF/NFI    CTF/NFI_DNA-bd-dom    CTF/NFI_DNA-bd_CS    CTF/NFI_DNA-bd_N    MAD_homology1_Dwarfin-type   
Domain families : Pfam (Sanger)CTF_NFI (PF00859)    MH1 (PF03165)    NfI_DNAbd_pre-N (PF10524)   
Domain families : Pfam (NCBI)pfam00859    pfam03165    pfam10524   
Domain families : Smart (EMBL)DWA (SM00523)  
DMDM Disease mutations4781
Blocks (Seattle)NFIB
SuperfamilyO00712
Human Protein AtlasENSG00000147862
Peptide AtlasO00712
HPRD09008
IPIIPI00953386   IPI00983554   IPI00984295   IPI00472959   IPI00470473   IPI00646731   IPI00646279   IPI00473116   IPI00642237   
Protein Interaction databases
DIP (DOE-UCLA)O00712
IntAct (EBI)O00712
FunCoupENSG00000147862
BioGRIDNFIB
STRING (EMBL)NFIB
ZODIACNFIB
Ontologies - Pathways
QuickGOO00712
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II transcription corepressor activity  chondrocyte differentiation  DNA binding  DNA binding  nucleus  nucleolus  DNA replication  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  glial cell differentiation  principal sensory nucleus of trigeminal nerve development  anterior commissure morphogenesis  hindbrain development  negative regulation of DNA binding  cerebellar mossy fiber  positive regulation of transcription from RNA polymerase II promoter  Clara cell differentiation  Type I pneumocyte differentiation  Type II pneumocyte differentiation  salivary gland cavitation  cell differentiation involved in salivary gland development  lung ciliated cell differentiation  commissural neuron axon guidance  negative regulation of pri-miRNA transcription from RNA polymerase II promoter  negative regulation of mesenchymal cell proliferation involved in lung development  negative regulation of epithelial cell proliferation involved in lung morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  RNA polymerase II transcription corepressor activity  chondrocyte differentiation  DNA binding  DNA binding  nucleus  nucleolus  DNA replication  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  glial cell differentiation  principal sensory nucleus of trigeminal nerve development  anterior commissure morphogenesis  hindbrain development  negative regulation of DNA binding  cerebellar mossy fiber  positive regulation of transcription from RNA polymerase II promoter  Clara cell differentiation  Type I pneumocyte differentiation  Type II pneumocyte differentiation  salivary gland cavitation  cell differentiation involved in salivary gland development  lung ciliated cell differentiation  commissural neuron axon guidance  negative regulation of pri-miRNA transcription from RNA polymerase II promoter  negative regulation of mesenchymal cell proliferation involved in lung development  negative regulation of epithelial cell proliferation involved in lung morphogenesis  
NDEx Network
Atlas of Cancer Signalling NetworkNFIB
Wikipedia pathwaysNFIB
Orthology - Evolution
OrthoDB4781
GeneTree (enSembl)ENSG00000147862
Phylogenetic Trees/Animal Genes : TreeFamNFIB
Homologs : HomoloGeneNFIB
Homology/Alignments : Family Browser (UCSC)NFIB
Gene fusions - Rearrangements
Fusion: TCGAMPDZ 9p23 NFIB 9p23 BRCA
Fusion: TCGAMYB 6q23.3 NFIB 9p23 BRCA
Fusion: TCGANFIB 9p23 FREM1 9p22.3 LUSC
Fusion: TCGANFIB 9p23 HEATR5B 2p22.2 BRCA
Fusion: TCGANFIB 9p23 STRN 2p22.2 BRCA
Fusion: TCGANFIB 9p23 ZDHHC21 9p22.3 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerNFIB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFIB
dbVarNFIB
ClinVarNFIB
1000_GenomesNFIB 
Exome Variant ServerNFIB
ExAC (Exome Aggregation Consortium)NFIB (select the gene name)
SNP (GeneSNP Utah)NFIB
SNP : HGBaseNFIB
Genetic variants : HAPMAPNFIB
Genomic Variants (DGV)NFIB [DGVbeta]
Mutations
ICGC Data PortalNFIB 
TCGA Data PortalNFIB 
Broad Tumor PortalNFIB
OASIS PortalNFIB [ Somatic mutations - Copy number]
Cancer Gene: CensusNFIB 
Somatic Mutations in Cancer : COSMICNFIB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFIB
DgiDB (Drug Gene Interaction Database)NFIB
DoCM (Curated mutations)NFIB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFIB (select a term)
intoGenNFIB
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:14081842-14314045
CONAN: Copy Number AnalysisNFIB 
Mutations and Diseases : HGMDNFIB
OMIM600728   
MedgenNFIB
Genetic Testing Registry NFIB
NextProtO00712 [Medical]
TSGene4781
GENETestsNFIB
Huge Navigator NFIB [HugePedia]  NFIB [HugeCancerGEM]
snp3D : Map Gene to Disease4781
BioCentury BCIQNFIB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4781
Chemical/Pharm GKB GenePA31591
Clinical trialNFIB
Miscellaneous
canSAR (ICR)NFIB (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFIB
GoPubMedNFIB
iHOPNFIB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:56:19 CEST 2016

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