NME2 (NME/NM23 nucleoside diphosphate kinase 2)

2003-02-01  

Identity

HGNC
LOCATION
17q21.33
LOCUSID
ALIAS
NDKB,NDPK-B,NDPKB,NM23-H2,NM23B,PUF
FUSION GENES

Other Information

Locus ID:

NCBI: 4831
MIM: 156491
HGNC: 7850
Ensembl: ENSG00000243678

Variants:

dbSNP: 4831
ClinVar: 4831
TCGA: ENSG00000243678
COSMIC: NME2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243678ENST00000393183F6XY72
ENSG00000243678ENST00000393190P22392
ENSG00000243678ENST00000393190Q6FHN3
ENSG00000243678ENST00000503064P22392
ENSG00000243678ENST00000503064Q6FHN3
ENSG00000243678ENST00000512737P22392
ENSG00000243678ENST00000512737Q6FHN3
ENSG00000243678ENST00000513177P22392
ENSG00000243678ENST00000513177Q6FHN3
ENSG00000243678ENST00000514264P22392
ENSG00000243678ENST00000514264Q6FHN3

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10005adefovir dipivoxilChemicalPathwayassociated
PA10204tenofovirChemicalPathwayassociated
PA450163lamivudineChemicalPathwayassociated
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
249700862014Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.42
208645122010A panel of sputum-based genomic marker for early detection of lung cancer.26
251938652014PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation.19
245232902014Regulation of the epithelial Ca²⁺ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1.18
252496192014Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
287170072017Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion.17
120098942002Structure-based mutational and functional analysis identify human NM23-H2 as a multifunctional enzyme.16
179641372008Discovery of NM23-H2 as an estrogen receptor beta-associated protein: role in estrogen-induced gene transcription and cell migration.15
259060112015CARMA3 Represses Metastasis Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis.14

Citation

Dessen P

NME2 (NME/NM23 nucleoside diphosphate kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41544/nme2