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NME2 (NME/NM23 nucleoside diphosphate kinase 2)

Identity

Other namesNDKB
NDPK-B
NDPKB
NM23-H2
NM23B
PUF
HGNC (Hugo) NME2
LocusID (NCBI) 4831
Atlas_Id 41544
Location 17q21.33
Location_base_pair Starts at 49242796 and ends at 49249105 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C3 (19p13.3) / NME2 (17q21.33)CDH4 (20q13.33) / NME2 (17q21.33)NME1 (17q21.33) / NME2 (17q21.33)
NME2 (17q21.33) / MAGI1 (3p14.1)RPL27 (17q21.31) / NME2 (17q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Skin: Melanoma

External links

Nomenclature
HGNC (Hugo)NME2   7850
Cards
Entrez_Gene (NCBI)NME2  4831  NME/NM23 nucleoside diphosphate kinase 2
AliasesNDKB; NDPK-B; NDPKB; NM23-H2; 
NM23B; PUF
GeneCards (Weizmann)NME2
Ensembl hg19 (Hinxton)ENSG00000011052 [Gene_View]  chr17:49242796-49249105 [Contig_View]  NME2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000011052 [Gene_View]  chr17:49242796-49249105 [Contig_View]  NME2 [Vega]
ICGC DataPortalENSG00000011052
TCGA cBioPortalNME2
AceView (NCBI)NME2
Genatlas (Paris)NME2
WikiGenes4831
SOURCE (Princeton)NME2
Genomic and cartography
GoldenPath hg19 (UCSC)NME2  -     chr17:49242796-49249105 +  17q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NME2  -     17q21.33   [Description]    (hg38-Dec_2013)
EnsemblNME2 - 17q21.33 [CytoView hg19]  NME2 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBINME2 [Mapview hg19]  NME2 [Mapview hg38]
OMIM156491   
Gene and transcription
Genbank (Entrez)BC002476 BC095458 BE501156 BF034471 BF058708
RefSeq transcript (Entrez)NM_001018137 NM_001018138 NM_001018139 NM_001198682 NM_002512
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)NME2
Cluster EST : UnigeneHs.463456 [ NCBI ]
CGAP (NCI)Hs.463456
Alternative Splicing GalleryENSG00000011052
Gene ExpressionNME2 [ NCBI-GEO ]   NME2 [ EBI - ARRAY_EXPRESS ]   NME2 [ SEEK ]   NME2 [ MEM ]
Gene Expression Viewer (FireBrowse)NME2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4831
GTEX Portal (Tissue expression)NME2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22392 (Uniprot)
NextProtP22392  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22392
Splice isoforms : SwissVarP22392 (Swissvar)
Catalytic activity : Enzyme2.7.4.6 [ Enzyme-Expasy ]   2.7.4.62.7.4.6 [ IntEnz-EBI ]   2.7.4.6 [ BRENDA ]   2.7.4.6 [ KEGG ]   
PhosPhoSitePlusP22392
Domaine pattern : Prosite (Expaxy)NDP_KINASES (PS00469)   
Domains : Interpro (EBI)Nucleoside_diP_kinase    Nucleoside_diP_kinase_AS   
Domain families : Pfam (Sanger)NDK (PF00334)   
Domain families : Pfam (NCBI)pfam00334   
Domain families : Smart (EMBL)NDK (SM00562)  
DMDM Disease mutations4831
Blocks (Seattle)NME2
PDB (SRS)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (PDBSum)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (IMB)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (RSDB)1NSK    1NUE    3BBB    3BBC    3BBF   
Structural Biology KnowledgeBase1NSK    1NUE    3BBB    3BBC    3BBF   
SCOP (Structural Classification of Proteins)1NSK    1NUE    3BBB    3BBC    3BBF   
CATH (Classification of proteins structures)1NSK    1NUE    3BBB    3BBC    3BBF   
SuperfamilyP22392
Human Protein AtlasENSG00000011052
Peptide AtlasP22392
HPRD01132
Protein Interaction databases
DIP (DOE-UCLA)P22392
IntAct (EBI)P22392
FunCoupENSG00000011052
BioGRIDNME2
STRING (EMBL)NME2
ZODIACNME2
Ontologies - Pathways
QuickGOP22392
Ontology : AmiGOruffle  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleoside diphosphate kinase activity  nucleoside diphosphate kinase activity  protein histidine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  focal adhesion  purine nucleotide metabolic process  nucleoside diphosphate phosphorylation  GTP biosynthetic process  pyrimidine nucleotide metabolic process  UTP biosynthetic process  CTP biosynthetic process  transcription, DNA-templated  regulation of transcription, DNA-templated  cell adhesion  integrin-mediated signaling pathway  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  peptidyl-histidine phosphorylation  lamellipodium  negative regulation of apoptotic process  positive regulation of keratinocyte differentiation  regulation of epidermis development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of epithelial cell proliferation  extracellular exosome  cell periphery  mitophagy in response to mitochondrial depolarization  
Ontology : EGO-EBIruffle  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleoside diphosphate kinase activity  nucleoside diphosphate kinase activity  protein histidine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  focal adhesion  purine nucleotide metabolic process  nucleoside diphosphate phosphorylation  GTP biosynthetic process  pyrimidine nucleotide metabolic process  UTP biosynthetic process  CTP biosynthetic process  transcription, DNA-templated  regulation of transcription, DNA-templated  cell adhesion  integrin-mediated signaling pathway  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  peptidyl-histidine phosphorylation  lamellipodium  negative regulation of apoptotic process  positive regulation of keratinocyte differentiation  regulation of epidermis development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of epithelial cell proliferation  extracellular exosome  cell periphery  mitophagy in response to mitochondrial depolarization  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkNME2
Wikipedia pathwaysNME2
Orthology - Evolution
OrthoDB4831
GeneTree (enSembl)ENSG00000011052
Phylogenetic Trees/Animal Genes : TreeFamNME2
Homologs : HomoloGeneNME2
Homology/Alignments : Family Browser (UCSC)NME2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerNME2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NME2
dbVarNME2
ClinVarNME2
1000_GenomesNME2 
Exome Variant ServerNME2
ExAC (Exome Aggregation Consortium)NME2 (select the gene name)
Genetic variants : HAPMAP4831
Genomic Variants (DGV)NME2 [DGVbeta]
Mutations
ICGC Data PortalNME2 
TCGA Data PortalNME2 
Broad Tumor PortalNME2
OASIS PortalNME2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNME2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NME2
DgiDB (Drug Gene Interaction Database)NME2
DoCM (Curated mutations)NME2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NME2 (select a term)
intoGenNME2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:49242796-49249105  ENSG00000011052
CONAN: Copy Number AnalysisNME2 
Mutations and Diseases : HGMDNME2
OMIM156491   
MedgenNME2
Genetic Testing Registry NME2
NextProtP22392 [Medical]
TSGene4831
GENETestsNME2
Huge Navigator NME2 [HugePedia]
snp3D : Map Gene to Disease4831
BioCentury BCIQNME2
ClinGenNME2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4831
Chemical/Pharm GKB GenePA250
Clinical trialNME2
Miscellaneous
canSAR (ICR)NME2 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNME2
EVEXNME2
GoPubMedNME2
iHOPNME2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:13:48 CEST 2016

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