Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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NME2 (NME/NM23 nucleoside diphosphate kinase 2)

Identity

Other namesNDKB
NDPK-B
NDPKB
NM23-H2
NM23B
PUF
HGNC (Hugo) NME2
LocusID (NCBI) 4831
Location 17q21.33
Location_base_pair Starts at 49242796 and ends at 49249105 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NME2   7850
Cards
Entrez_Gene (NCBI)NME2  4831  NME/NM23 nucleoside diphosphate kinase 2
GeneCards (Weizmann)NME2
Ensembl hg19 (Hinxton)ENSG00000011052 [Gene_View]  chr17:49242796-49249105 [Contig_View]  NME2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000011052 [Gene_View]  chr17:49242796-49249105 [Contig_View]  NME2 [Vega]
ICGC DataPortalENSG00000011052
cBioPortalNME2
AceView (NCBI)NME2
Genatlas (Paris)NME2
WikiGenes4831
SOURCE (Princeton)NME2
Genomic and cartography
GoldenPath hg19 (UCSC)NME2  -     chr17:49242796-49249105 +  17q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NME2  -     17q21.33   [Description]    (hg38-Dec_2013)
EnsemblNME2 - 17q21.33 [CytoView hg19]  NME2 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBINME2 [Mapview hg19]  NME2 [Mapview hg38]
OMIM156491   
Gene and transcription
Genbank (Entrez)BC002476 BC095458 BE501156 BF034471 BF058708
RefSeq transcript (Entrez)NM_001018137 NM_001018138 NM_001018139 NM_001198682 NM_002512
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)NME2
Cluster EST : UnigeneHs.463456 [ NCBI ]
CGAP (NCI)Hs.463456
Alternative Splicing : Fast-db (Paris)GSHG0012648
Alternative Splicing GalleryENSG00000011052
Gene ExpressionNME2 [ NCBI-GEO ]     NME2 [ SEEK ]   NME2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22392 (Uniprot)
NextProtP22392  [Medical]
With graphics : InterProP22392
Splice isoforms : SwissVarP22392 (Swissvar)
Catalytic activity : Enzyme2.7.4.6 [ Enzyme-Expasy ]   2.7.4.62.7.4.6 [ IntEnz-EBI ]   2.7.4.6 [ BRENDA ]   2.7.4.6 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)NDP_KINASES (PS00469)   
Domains : Interpro (EBI)Nucleoside_diP_kinase    Nucleoside_diP_kinase_AS   
Related proteins : CluSTrP22392
Domain families : Pfam (Sanger)NDK (PF00334)   
Domain families : Pfam (NCBI)pfam00334   
Domain families : Smart (EMBL)NDK (SM00562)  
DMDM Disease mutations4831
Blocks (Seattle)P22392
PDB (SRS)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (PDBSum)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (IMB)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (RSDB)1NSK    1NUE    3BBB    3BBC    3BBF   
Human Protein AtlasENSG00000011052
Peptide AtlasP22392
HPRD01132
Protein Interaction databases
DIP (DOE-UCLA)P22392
IntAct (EBI)P22392
FunCoupENSG00000011052
BioGRIDNME2
IntegromeDBNME2
STRING (EMBL)NME2
Ontologies - Pathways
QuickGOP22392
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  ruffle  negative regulation of myeloid leukocyte differentiation  single-stranded DNA binding  sequence-specific DNA binding transcription factor activity  nucleoside diphosphate kinase activity  protein histidine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  centrosome  cytosol  cytosol  intermediate filament  focal adhesion  purine nucleotide metabolic process  nucleoside diphosphate phosphorylation  GTP biosynthetic process  pyrimidine nucleotide metabolic process  UTP biosynthetic process  CTP biosynthetic process  transcription, DNA-templated  regulation of transcription, DNA-templated  cell adhesion  integrin-mediated signaling pathway  nucleoside triphosphate biosynthetic process  negative regulation of gene expression  positive regulation of neuron projection development  response to amine  nucleobase-containing small molecule interconversion  membrane  peptidyl-histidine phosphorylation  intermediate filament binding  protein kinase binding  hippocampus development  lamellipodium  response to testosterone  cellular response to drug  gamma-tubulin binding  negative regulation of apoptotic process  small molecule metabolic process  positive regulation of keratinocyte differentiation  regulation of epidermis development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  response to cAMP  nucleobase-containing small molecule metabolic process  extracellular exosome  cellular response to glucose stimulus  cellular response to fatty acid  cell periphery  regulation of mitochondrion degradation  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  ruffle  negative regulation of myeloid leukocyte differentiation  single-stranded DNA binding  sequence-specific DNA binding transcription factor activity  nucleoside diphosphate kinase activity  protein histidine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  centrosome  cytosol  cytosol  intermediate filament  focal adhesion  purine nucleotide metabolic process  nucleoside diphosphate phosphorylation  GTP biosynthetic process  pyrimidine nucleotide metabolic process  UTP biosynthetic process  CTP biosynthetic process  transcription, DNA-templated  regulation of transcription, DNA-templated  cell adhesion  integrin-mediated signaling pathway  nucleoside triphosphate biosynthetic process  negative regulation of gene expression  positive regulation of neuron projection development  response to amine  nucleobase-containing small molecule interconversion  membrane  peptidyl-histidine phosphorylation  intermediate filament binding  protein kinase binding  hippocampus development  lamellipodium  response to testosterone  cellular response to drug  gamma-tubulin binding  negative regulation of apoptotic process  small molecule metabolic process  positive regulation of keratinocyte differentiation  regulation of epidermis development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  perinuclear region of cytoplasm  positive regulation of epithelial cell proliferation  response to cAMP  nucleobase-containing small molecule metabolic process  extracellular exosome  cellular response to glucose stimulus  cellular response to fatty acid  cell periphery  regulation of mitochondrion degradation  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism   
Protein Interaction DatabaseNME2
DoCM (Curated mutations)NME2
Wikipedia pathwaysNME2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerNME2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NME2
dbVarNME2
ClinVarNME2
1000_GenomesNME2 
Exome Variant ServerNME2
SNP (GeneSNP Utah)NME2
SNP : HGBaseNME2
Genetic variants : HAPMAPNME2
Genomic Variants (DGV)NME2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000011052 
Somatic Mutations in Cancer : COSMICNME2 
CONAN: Copy Number AnalysisNME2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:49242796-49249105
Mutations and Diseases : HGMDNME2
OMIM156491   
MedgenNME2
NextProtP22392 [Medical]
GENETestsNME2
Disease Genetic AssociationNME2
Huge Navigator NME2 [HugePedia]  NME2 [HugeCancerGEM]
snp3D : Map Gene to Disease4831
DGIdb (Drug Gene Interaction db)NME2
General knowledge
Homologs : HomoloGeneNME2
Homology/Alignments : Family Browser (UCSC)NME2
Phylogenetic Trees/Animal Genes : TreeFamNME2
Chemical/Protein Interactions : CTD4831
Chemical/Pharm GKB GenePA250
Clinical trialNME2
Cancer Resource (Charite)ENSG00000011052
Other databases
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
CoreMineNME2
GoPubMedNME2
iHOPNME2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 16:41:23 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.