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NME2 (NME/NM23 nucleoside diphosphate kinase 2)

Identity

Other namesNDKB
NDPK-B
NDPKB
NM23-H2
NM23B
PUF
HGNC (Hugo) NME2
LocusID (NCBI) 4831
Location 17q21.33
Location_base_pair Starts at 49242796 and ends at 49249105 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NME2   7850
Cards
Entrez_Gene (NCBI)NME2  4831  NME/NM23 nucleoside diphosphate kinase 2
GeneCards (Weizmann)NME2
Ensembl (Hinxton)ENSG00000011052 [Gene_View]  chr17:49242796-49249105 [Contig_View]  NME2 [Vega]
ICGC DataPortalENSG00000011052
cBioPortalNME2
AceView (NCBI)NME2
Genatlas (Paris)NME2
WikiGenes4831
SOURCE (Princeton)NM_001018137 NM_001018138 NM_001018139 NM_001198682 NM_002512
Genomic and cartography
GoldenPath (UCSC)NME2  -  17q21.33   chr17:49242796-49249105 +  17q21.33   [Description]    (hg19-Feb_2009)
EnsemblNME2 - 17q21.33 [CytoView]
Mapping of homologs : NCBINME2 [Mapview]
OMIM156491   
Gene and transcription
Genbank (Entrez)BC002476 BC095458 BE501156 BF034471 BF058708
RefSeq transcript (Entrez)NM_001018137 NM_001018138 NM_001018139 NM_001198682 NM_002512
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010783 NW_001838448 NW_004929407
Consensus coding sequences : CCDS (NCBI)NME2
Cluster EST : UnigeneHs.463456 [ NCBI ]
CGAP (NCI)Hs.463456
Alternative Splicing : Fast-db (Paris)GSHG0012648
Alternative Splicing GalleryENSG00000011052
Gene ExpressionNME2 [ NCBI-GEO ]     NME2 [ SEEK ]   NME2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22392 (Uniprot)
NextProtP22392  [Medical]
With graphics : InterProP22392
Splice isoforms : SwissVarP22392 (Swissvar)
Catalytic activity : Enzyme2.7.4.6 [ Enzyme-Expasy ]   2.7.4.62.7.4.6 [ IntEnz-EBI ]   2.7.4.6 [ BRENDA ]   2.7.4.6 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)NDP_KINASES (PS00469)   
Domains : Interpro (EBI)Nucleoside_diP_kinase [organisation]   Nucleoside_diP_kinase_AS [organisation]  
Related proteins : CluSTrP22392
Domain families : Pfam (Sanger)NDK (PF00334)   
Domain families : Pfam (NCBI)pfam00334   
Domain families : Smart (EMBL)NDK (SM00562)  
DMDM Disease mutations4831
Blocks (Seattle)P22392
PDB (SRS)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (PDBSum)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (IMB)1NSK    1NUE    3BBB    3BBC    3BBF   
PDB (RSDB)1NSK    1NUE    3BBB    3BBC    3BBF   
Human Protein AtlasENSG00000011052 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP22392
HPRD01132
Protein Interaction databases
DIP (DOE-UCLA)P22392
IntAct (EBI)P22392
FunCoupENSG00000011052
BioGRIDNME2
InParanoidP22392
Interologous Interaction database P22392
IntegromeDBNME2
STRING (EMBL)NME2
Ontologies - Pathways
Ontology : AmiGOruffle  DNA binding  sequence-specific DNA binding transcription factor activity  nucleoside diphosphate kinase activity  protein histidine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  focal adhesion  nucleoside diphosphate phosphorylation  GTP biosynthetic process  UTP biosynthetic process  CTP biosynthetic process  transcription, DNA-templated  regulation of transcription, DNA-templated  cell adhesion  integrin-mediated signaling pathway  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  peptidyl-histidine phosphorylation  lamellipodium  negative regulation of apoptotic process  small molecule metabolic process  positive regulation of keratinocyte differentiation  regulation of epidermis development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of epithelial cell proliferation  nucleobase-containing small molecule metabolic process  extracellular vesicular exosome  cell periphery  
Ontology : EGO-EBIruffle  DNA binding  sequence-specific DNA binding transcription factor activity  nucleoside diphosphate kinase activity  protein histidine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  focal adhesion  nucleoside diphosphate phosphorylation  GTP biosynthetic process  UTP biosynthetic process  CTP biosynthetic process  transcription, DNA-templated  regulation of transcription, DNA-templated  cell adhesion  integrin-mediated signaling pathway  nucleoside triphosphate biosynthetic process  nucleobase-containing small molecule interconversion  peptidyl-histidine phosphorylation  lamellipodium  negative regulation of apoptotic process  small molecule metabolic process  positive regulation of keratinocyte differentiation  regulation of epidermis development  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of epithelial cell proliferation  nucleobase-containing small molecule metabolic process  extracellular vesicular exosome  cell periphery  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism   
Protein Interaction DatabaseNME2
Wikipedia pathwaysNME2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NME2
snp3D : Map Gene to Disease4831
SNP (GeneSNP Utah)NME2
SNP : HGBaseNME2
Genetic variants : HAPMAPNME2
Exome VariantNME2
1000_GenomesNME2 
ICGC programENSG00000011052 
Somatic Mutations in Cancer : COSMICNME2 
CONAN: Copy Number AnalysisNME2 
Mutations and Diseases : HGMDNME2
Mutations and Diseases : intOGenNME2
Genomic VariantsNME2  NME2 [DGVbeta]
dbVarNME2
ClinVarNME2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM156491   
MedgenNME2
GENETestsNME2
Disease Genetic AssociationNME2
Huge Navigator NME2 [HugePedia]  NME2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneNME2
Homology/Alignments : Family Browser (UCSC)NME2
Phylogenetic Trees/Animal Genes : TreeFamNME2
Chemical/Protein Interactions : CTD4831
Chemical/Pharm GKB GenePA250
Clinical trialNME2
Cancer Resource (Charite)ENSG00000011052
Other databases
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
CoreMineNME2
iHOPNME2
OncoSearchNME2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:57:48 CEST 2014

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