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NOS1 (nitric oxide synthase 1)

Identity

Alias_namesNOS
nitric oxide synthase 1 (neuronal)
Alias_symbol (synonym)nNOS
Other aliasIHPS1
N-NOS
NC-NOS
bNOS
HGNC (Hugo) NOS1
LocusID (NCBI) 4842
Atlas_Id 43850
Location 12q24.22  [Link to chromosome band 12q24]
Location_base_pair Starts at 117208142 and ends at 117361802 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NOS1 (12q24.22) / NFE2L1 (17q21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOS1   7872
Cards
Entrez_Gene (NCBI)NOS1  4842  nitric oxide synthase 1
AliasesIHPS1; N-NOS; NC-NOS; NOS; 
bNOS; nNOS
GeneCards (Weizmann)NOS1
Ensembl hg19 (Hinxton)ENSG00000089250 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089250 [Gene_View]  chr12:117208142-117361802 [Contig_View]  NOS1 [Vega]
ICGC DataPortalENSG00000089250
TCGA cBioPortalNOS1
AceView (NCBI)NOS1
Genatlas (Paris)NOS1
WikiGenes4842
SOURCE (Princeton)NOS1
Genetics Home Reference (NIH)NOS1
Genomic and cartography
GoldenPath hg38 (UCSC)NOS1  -     chr12:117208142-117361802 -  12q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOS1  -     12q24.22   [Description]    (hg19-Feb_2009)
EnsemblNOS1 - 12q24.22 [CytoView hg19]  NOS1 - 12q24.22 [CytoView hg38]
Mapping of homologs : NCBINOS1 [Mapview hg19]  NOS1 [Mapview hg38]
OMIM163731   
Gene and transcription
Genbank (Entrez)AF446131 AF446132 AF446133 AF446134 AF446135
RefSeq transcript (Entrez)NM_000620 NM_001204213 NM_001204214 NM_001204218
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NOS1
Cluster EST : UnigeneHs.735734 [ NCBI ]
CGAP (NCI)Hs.735734
Alternative Splicing GalleryENSG00000089250
Gene ExpressionNOS1 [ NCBI-GEO ]   NOS1 [ EBI - ARRAY_EXPRESS ]   NOS1 [ SEEK ]   NOS1 [ MEM ]
Gene Expression Viewer (FireBrowse)NOS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4842
GTEX Portal (Tissue expression)NOS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29475   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29475  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29475
Splice isoforms : SwissVarP29475
Catalytic activity : Enzyme1.14.13.39 [ Enzyme-Expasy ]   1.14.13.391.14.13.39 [ IntEnz-EBI ]   1.14.13.39 [ BRENDA ]   1.14.13.39 [ KEGG ]   
PhosPhoSitePlusP29475
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)    FLAVODOXIN_LIKE (PS50902)    NOS (PS60001)    PDZ (PS50106)   
Domains : Interpro (EBI)FAD-binding_1    Fd_Rdtase_FAD-bd    Flavdoxin-like    Flavodoxin/NO_synth    Flavoprot_Pyr_Nucl_cyt_Rdtase    Flavoprotein-like_dom    NADPH_Cyt_P450_Rdtase_dom3    NOS_euk    NOS_N    OxRdtase_FAD/NAD-bd    PDZ    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_1 (PF00667)    Flavodoxin_1 (PF00258)    NAD_binding_1 (PF00175)    NO_synthase (PF02898)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00667    pfam00258    pfam00175    pfam02898    pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)NOS1
DMDM Disease mutations4842
Blocks (Seattle)NOS1
PDB (SRS)4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
PDB (PDBSum)4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
PDB (IMB)4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
PDB (RSDB)4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
Structural Biology KnowledgeBase4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
SCOP (Structural Classification of Proteins)4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
CATH (Classification of proteins structures)4D1N    4UCH    4UH5    4UH6    4V3U    5ADF    5ADG    5ADI    5FVU    5FVV    5FVW    5FVX   
SuperfamilyP29475
Human Protein AtlasENSG00000089250
Peptide AtlasP29475
HPRD01226
IPIIPI00217225   IPI00472618   IPI00216232   IPI00953136   IPI01015698   IPI00746356   IPI00795843   
Protein Interaction databases
DIP (DOE-UCLA)P29475
IntAct (EBI)P29475
FunCoupENSG00000089250
BioGRIDNOS1
STRING (EMBL)NOS1
ZODIACNOS1
Ontologies - Pathways
QuickGOP29475
Ontology : AmiGOresponse to hypoxia  photoreceptor inner segment  regulation of sodium ion transport  NADPH-hemoprotein reductase activity  nitric-oxide synthase activity  nitric-oxide synthase activity  nitric-oxide synthase activity  iron ion binding  protein binding  calmodulin binding  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytoskeleton  plasma membrane  caveola  arginine catabolic process  nitric oxide biosynthetic process  striated muscle contraction  nitric oxide mediated signal transduction  myoblast fusion  response to heat  FMN binding  negative regulation of calcium ion transport into cytosol  sarcoplasmic reticulum  sodium channel regulator activity  peptidyl-cysteine S-nitrosylation  heme binding  Z disc  T-tubule  positive regulation of guanylate cyclase activity  multicellular organismal response to stress  tetrahydrobiopterin binding  arginine binding  positive regulation of histone acetylation  neurotransmitter biosynthetic process  vasodilation  vasodilation  sarcolemma  exogenous drug catabolic process  dendritic spine  protein complex  negative regulation of potassium ion transport  ion channel binding  ion channel binding  membrane raft  synapse  cell redox homeostasis  negative regulation of blood pressure  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  cadmium ion binding  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  NADP binding  regulation of neurogenesis  negative regulation of hydrolase activity  negative regulation of serotonin uptake  negative regulation of calcium ion transport  oxidation-reduction process  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  cellular response to growth factor stimulus  scaffold protein binding  positive regulation of the force of heart contraction  retrograde trans-synaptic signaling by nitric oxide  negative regulation of adrenergic receptor signaling pathway involved in heart process  positive regulation of adrenergic receptor signaling pathway involved in heart process  positive regulation of sodium ion transmembrane transport  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  regulation of cardiac conduction  ryanodine receptor complex  
Ontology : EGO-EBIresponse to hypoxia  photoreceptor inner segment  regulation of sodium ion transport  NADPH-hemoprotein reductase activity  nitric-oxide synthase activity  nitric-oxide synthase activity  nitric-oxide synthase activity  iron ion binding  protein binding  calmodulin binding  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytoskeleton  plasma membrane  caveola  arginine catabolic process  nitric oxide biosynthetic process  striated muscle contraction  nitric oxide mediated signal transduction  myoblast fusion  response to heat  FMN binding  negative regulation of calcium ion transport into cytosol  sarcoplasmic reticulum  sodium channel regulator activity  peptidyl-cysteine S-nitrosylation  heme binding  Z disc  T-tubule  positive regulation of guanylate cyclase activity  multicellular organismal response to stress  tetrahydrobiopterin binding  arginine binding  positive regulation of histone acetylation  neurotransmitter biosynthetic process  vasodilation  vasodilation  sarcolemma  exogenous drug catabolic process  dendritic spine  protein complex  negative regulation of potassium ion transport  ion channel binding  ion channel binding  membrane raft  synapse  cell redox homeostasis  negative regulation of blood pressure  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  cadmium ion binding  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  NADP binding  regulation of neurogenesis  negative regulation of hydrolase activity  negative regulation of serotonin uptake  negative regulation of calcium ion transport  oxidation-reduction process  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  cellular response to growth factor stimulus  scaffold protein binding  positive regulation of the force of heart contraction  retrograde trans-synaptic signaling by nitric oxide  negative regulation of adrenergic receptor signaling pathway involved in heart process  positive regulation of adrenergic receptor signaling pathway involved in heart process  positive regulation of sodium ion transmembrane transport  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  regulation of cardiac conduction  ryanodine receptor complex  
Pathways : BIOCARTASUMOylation as a mechanism to modulate CtBP-dependent gene responses [Genes]    Nitric Oxide Signaling Pathway [Genes]   
Pathways : KEGG   
NDEx NetworkNOS1
Atlas of Cancer Signalling NetworkNOS1
Wikipedia pathwaysNOS1
Orthology - Evolution
OrthoDB4842
GeneTree (enSembl)ENSG00000089250
Phylogenetic Trees/Animal Genes : TreeFamNOS1
HOVERGENP29475
HOGENOMP29475
Homologs : HomoloGeneNOS1
Homology/Alignments : Family Browser (UCSC)NOS1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOS1
dbVarNOS1
ClinVarNOS1
1000_GenomesNOS1 
Exome Variant ServerNOS1
ExAC (Exome Aggregation Consortium)NOS1 (select the gene name)
Genetic variants : HAPMAP4842
Genomic Variants (DGV)NOS1 [DGVbeta]
DECIPHERNOS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOS1 
Mutations
ICGC Data PortalNOS1 
TCGA Data PortalNOS1 
Broad Tumor PortalNOS1
OASIS PortalNOS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch NOS1
DgiDB (Drug Gene Interaction Database)NOS1
DoCM (Curated mutations)NOS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOS1 (select a term)
intoGenNOS1
Cancer3DNOS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163731   
Orphanet302   
MedgenNOS1
Genetic Testing Registry NOS1
NextProtP29475 [Medical]
TSGene4842
GENETestsNOS1
Target ValidationNOS1
Huge Navigator NOS1 [HugePedia]
snp3D : Map Gene to Disease4842
BioCentury BCIQNOS1
ClinGenNOS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4842
Chemical/Pharm GKB GenePA252
Clinical trialNOS1
Miscellaneous
canSAR (ICR)NOS1 (select the gene name)
Probes
Litterature
PubMed335 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOS1
EVEXNOS1
GoPubMedNOS1
iHOPNOS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:47:08 CEST 2017

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