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NOS2 (nitric oxide synthase 2)

Identity

Alias (NCBI)HEP-NOS
INOS
NOS
NOS2A
HGNC (Hugo) NOS2
HGNC Alias symbiNOS
NOS
HEP-NOS
HGNC Previous nameNOS2A
HGNC Previous namenitric oxide synthase 2A (inducible, hepatocytes)
 nitric oxide synthase 2, inducible
LocusID (NCBI) 4843
Atlas_Id 41553
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 27756766 and ends at 27800529 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NOS2 (17q11.2) / ERBB2 (17q12)NOS2 (17q11.2) / TTC37 (5q15)ZDHHC3 (3p21.31) / NOS2 (17q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q13;q12) EEF1G/OOEP


External links

 

Nomenclature
HGNC (Hugo)NOS2   7873
Cards
Entrez_Gene (NCBI)NOS2    nitric oxide synthase 2
AliasesHEP-NOS; INOS; NOS; NOS2A
GeneCards (Weizmann)NOS2
Ensembl hg19 (Hinxton)ENSG00000007171 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000007171 [Gene_View]  ENSG00000007171 [Sequence]  chr17:27756766-27800529 [Contig_View]  NOS2 [Vega]
ICGC DataPortalENSG00000007171
TCGA cBioPortalNOS2
AceView (NCBI)NOS2
Genatlas (Paris)NOS2
SOURCE (Princeton)NOS2
Genetics Home Reference (NIH)NOS2
Genomic and cartography
GoldenPath hg38 (UCSC)NOS2  -     chr17:27756766-27800529 -  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NOS2  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathNOS2 - 17q11.2 [CytoView hg19]  NOS2 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000007171
Genome Data Viewer NCBINOS2 [Mapview hg19]  
OMIM163730   611162   
Gene and transcription
Genbank (Entrez)AB022318 AF068236 AK304252 BC130283 BC144126
RefSeq transcript (Entrez)NM_000625 NM_153292
Consensus coding sequences : CCDS (NCBI)NOS2
Gene ExpressionNOS2 [ NCBI-GEO ]   NOS2 [ EBI - ARRAY_EXPRESS ]   NOS2 [ SEEK ]   NOS2 [ MEM ]
Gene Expression Viewer (FireBrowse)NOS2 [ Firebrowse - Broad ]
GenevisibleExpression of NOS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4843
GTEX Portal (Tissue expression)NOS2
Human Protein AtlasENSG00000007171-NOS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35228   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35228  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35228
Catalytic activity : Enzyme1.14.13.39 [ Enzyme-Expasy ]   1.14.13.391.14.13.39 [ IntEnz-EBI ]   1.14.13.39 [ BRENDA ]   1.14.13.39 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP35228
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)    FLAVODOXIN_LIKE (PS50902)    NOS (PS60001)   
Domains : Interpro (EBI)CysJ-like_FAD-binding    FAD-bd_FR_type    Flavdoxin-like    Flavodoxin/NO_synth    Flavoprot_Pyr_Nucl_cyt_Rdtase    Flavoprotein-like_sf    FNR_nucleotide-bd    NADPH_Cyt_P450_Rdtase_alpha    NOS_euk    NOS_N    NOS_N_sf    OxRdtase_FAD/NAD-bd    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_1 (PF00667)    Flavodoxin_1 (PF00258)    NAD_binding_1 (PF00175)    NO_synthase (PF02898)   
Domain families : Pfam (NCBI)pfam00667    pfam00258    pfam00175    pfam02898   
Conserved Domain (NCBI)NOS2
PDB (RSDB)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
PDB Europe1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
PDB (PDBSum)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
PDB (IMB)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
Structural Biology KnowledgeBase1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
SCOP (Structural Classification of Proteins)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
CATH (Classification of proteins structures)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS    5TP6    5XN3    6JWM    6JWN    6KEY   
SuperfamilyP35228
AlphaFold pdb e-kbP35228   
Human Protein Atlas [tissue]ENSG00000007171-NOS2 [tissue]
HPRD01225
Protein Interaction databases
DIP (DOE-UCLA)P35228
IntAct (EBI)P35228
BioGRIDNOS2
STRING (EMBL)NOS2
ZODIACNOS2
Ontologies - Pathways
QuickGOP35228
Ontology : AmiGOresponse to hypoxia  positive regulation of leukocyte mediated cytotoxicity  innate immune response in mucosa  nitric-oxide synthase activity  nitric-oxide synthase activity  protein binding  calmodulin binding  nucleus  nucleus  nucleoplasm  cytoplasm  peroxisome  peroxisomal matrix  cytosol  cytosol  cytosol  plasma membrane  arginine catabolic process  arginine catabolic process  superoxide metabolic process  nitric oxide biosynthetic process  nitric oxide biosynthetic process  inflammatory response  nitric oxide mediated signal transduction  circadian rhythm  protein localization  response to bacterium  response to hormone  FMN binding  FMN binding  negative regulation of gene expression  vesicle membrane  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  peptidyl-cysteine S-nitrosylation  cytokine-mediated signaling pathway  heme binding  cortical cytoskeleton  positive regulation of guanylate cyclase activity  prostaglandin secretion  response to lipopolysaccharide  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  tetrahydrobiopterin binding  arginine binding  cellular response to drug  regulation of cell population proliferation  negative regulation of protein catabolic process  defense response to bacterium  defense response to bacterium  defense response to bacterium  protein homodimerization activity  regulation of cellular respiration  cell redox homeostasis  negative regulation of blood pressure  metal ion binding  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  flavin adenine dinucleotide binding  NADP binding  regulation of insulin secretion  defense response to Gram-negative bacterium  positive regulation of killing of cells of other organism  cellular response to lipopolysaccharide  cellular response to interferon-gamma  regulation of cytokine production involved in inflammatory response  
Ontology : EGO-EBIresponse to hypoxia  positive regulation of leukocyte mediated cytotoxicity  innate immune response in mucosa  nitric-oxide synthase activity  nitric-oxide synthase activity  protein binding  calmodulin binding  nucleus  nucleus  nucleoplasm  cytoplasm  peroxisome  peroxisomal matrix  cytosol  cytosol  cytosol  plasma membrane  arginine catabolic process  arginine catabolic process  superoxide metabolic process  nitric oxide biosynthetic process  nitric oxide biosynthetic process  inflammatory response  nitric oxide mediated signal transduction  circadian rhythm  protein localization  response to bacterium  response to hormone  FMN binding  FMN binding  negative regulation of gene expression  vesicle membrane  oxidoreductase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  peptidyl-cysteine S-nitrosylation  cytokine-mediated signaling pathway  heme binding  cortical cytoskeleton  positive regulation of guanylate cyclase activity  prostaglandin secretion  response to lipopolysaccharide  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  tetrahydrobiopterin binding  arginine binding  cellular response to drug  regulation of cell population proliferation  negative regulation of protein catabolic process  defense response to bacterium  defense response to bacterium  defense response to bacterium  protein homodimerization activity  regulation of cellular respiration  cell redox homeostasis  negative regulation of blood pressure  metal ion binding  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  flavin adenine dinucleotide binding  NADP binding  regulation of insulin secretion  defense response to Gram-negative bacterium  positive regulation of killing of cells of other organism  cellular response to lipopolysaccharide  cellular response to interferon-gamma  regulation of cytokine production involved in inflammatory response  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGArginine and proline metabolism    Calcium signaling pathway    HIF-1 signaling pathway    Peroxisome    Salmonella infection    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Amoebiasis    Tuberculosis    Pathways in cancer    Small cell lung cancer   
NDEx NetworkNOS2
Atlas of Cancer Signalling NetworkNOS2
Wikipedia pathwaysNOS2
Orthology - Evolution
OrthoDB4843
GeneTree (enSembl)ENSG00000007171
Phylogenetic Trees/Animal Genes : TreeFamNOS2
Homologs : HomoloGeneNOS2
Homology/Alignments : Family Browser (UCSC)NOS2
Gene fusions - Rearrangements
Fusion : QuiverNOS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOS2
dbVarNOS2
ClinVarNOS2
MonarchNOS2
1000_GenomesNOS2 
Exome Variant ServerNOS2
GNOMAD BrowserENSG00000007171
Varsome BrowserNOS2
ACMGNOS2 variants
VarityP35228
Genomic Variants (DGV)NOS2 [DGVbeta]
DECIPHERNOS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNOS2 
Mutations
ICGC Data PortalNOS2 
TCGA Data PortalNOS2 
Broad Tumor PortalNOS2
OASIS PortalNOS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNOS2
Mutations and Diseases : HGMDNOS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNOS2
DgiDB (Drug Gene Interaction Database)NOS2
DoCM (Curated mutations)NOS2
CIViC (Clinical Interpretations of Variants in Cancer)NOS2
Cancer3DNOS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163730    611162   
Orphanet
DisGeNETNOS2
MedgenNOS2
Genetic Testing Registry NOS2
NextProtP35228 [Medical]
GENETestsNOS2
Target ValidationNOS2
Huge Navigator NOS2 [HugePedia]
ClinGenNOS2
Clinical trials, drugs, therapy
MyCancerGenomeNOS2
Protein Interactions : CTDNOS2
Pharm GKB GenePA164724093
Pharm GKB PathwaysPA165292164   PA165292177   PA166121942   
PharosP35228
Clinical trialNOS2
Miscellaneous
canSAR (ICR)NOS2
HarmonizomeNOS2
DataMed IndexNOS2
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNOS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:23:04 CEST 2021

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