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NOS2 (nitric oxide synthase 2)

Identity

Alias_namesNOS2A
nitric oxide synthase 2A (inducible, hepatocytes)
nitric oxide synthase 2, inducible
Alias_symbol (synonym)iNOS
NOS
HEP-NOS
Other aliasINOS
HGNC (Hugo) NOS2
LocusID (NCBI) 4843
Atlas_Id 41553
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 26083792 and ends at 26127555 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NOS2 (17q11.2) / ERBB2 (17q12)NOS2 (17q11.2) / TTC37 (5q15)ZDHHC3 (3p21.31) / NOS2 (17q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NOS2   7873
Cards
Entrez_Gene (NCBI)NOS2  4843  nitric oxide synthase 2
AliasesHEP-NOS; INOS; NOS; NOS2A
GeneCards (Weizmann)NOS2
Ensembl hg19 (Hinxton)ENSG00000007171 [Gene_View]  chr17:26083792-26127555 [Contig_View]  NOS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000007171 [Gene_View]  chr17:26083792-26127555 [Contig_View]  NOS2 [Vega]
ICGC DataPortalENSG00000007171
TCGA cBioPortalNOS2
AceView (NCBI)NOS2
Genatlas (Paris)NOS2
WikiGenes4843
SOURCE (Princeton)NOS2
Genetics Home Reference (NIH)NOS2
Genomic and cartography
GoldenPath hg19 (UCSC)NOS2  -     chr17:26083792-26127555 -  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NOS2  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblNOS2 - 17q11.2 [CytoView hg19]  NOS2 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBINOS2 [Mapview hg19]  NOS2 [Mapview hg38]
OMIM145500   163730   611162   
Gene and transcription
Genbank (Entrez)AB022318 AF068236 AK304252 BC130283 BC144126
RefSeq transcript (Entrez)NM_000625 NM_153292
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_011470 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)NOS2
Cluster EST : UnigeneHs.709191 [ NCBI ]
CGAP (NCI)Hs.709191
Alternative Splicing GalleryENSG00000007171
Gene ExpressionNOS2 [ NCBI-GEO ]   NOS2 [ EBI - ARRAY_EXPRESS ]   NOS2 [ SEEK ]   NOS2 [ MEM ]
Gene Expression Viewer (FireBrowse)NOS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4843
GTEX Portal (Tissue expression)NOS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35228   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35228  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35228
Splice isoforms : SwissVarP35228
Catalytic activity : Enzyme1.14.13.39 [ Enzyme-Expasy ]   1.14.13.391.14.13.39 [ IntEnz-EBI ]   1.14.13.39 [ BRENDA ]   1.14.13.39 [ KEGG ]   
PhosPhoSitePlusP35228
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)    FLAVODOXIN_LIKE (PS50902)    NOS (PS60001)   
Domains : Interpro (EBI)FAD-binding_1    Fd_Rdtase_FAD-bd    Flavdoxin-like    Flavodoxin/NO_synth    Flavoprot_Pyr_Nucl_cyt_Rdtase    Flavoprotein-like_dom    NADPH_Cyt_P450_Rdtase_dom3    NOS_N    OxRdtase_FAD/NAD-bd    Riboflavin_synthase-like_b-brl   
Domain families : Pfam (Sanger)FAD_binding_1 (PF00667)    Flavodoxin_1 (PF00258)    NAD_binding_1 (PF00175)    NO_synthase (PF02898)   
Domain families : Pfam (NCBI)pfam00667    pfam00258    pfam00175    pfam02898   
Conserved Domain (NCBI)NOS2
DMDM Disease mutations4843
Blocks (Seattle)NOS2
PDB (SRS)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
PDB (PDBSum)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
PDB (IMB)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
PDB (RSDB)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
Structural Biology KnowledgeBase1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
SCOP (Structural Classification of Proteins)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
CATH (Classification of proteins structures)1NSI    2LL6    2NSI    3E7G    3EJ8    3HR4    4CX7    4NOS   
SuperfamilyP35228
Human Protein AtlasENSG00000007171
Peptide AtlasP35228
HPRD01225
IPIIPI00017304   IPI00220339   IPI00001613   
Protein Interaction databases
DIP (DOE-UCLA)P35228
IntAct (EBI)P35228
FunCoupENSG00000007171
BioGRIDNOS2
STRING (EMBL)NOS2
ZODIACNOS2
Ontologies - Pathways
QuickGOP35228
Ontology : AmiGOresponse to hypoxia  positive regulation of leukocyte mediated cytotoxicity  innate immune response in mucosa  nitric-oxide synthase activity  nitric-oxide synthase activity  receptor binding  iron ion binding  protein binding  calmodulin binding  intracellular  nucleus  cytoplasm  peroxisome  cytosol  cytosol  arginine catabolic process  superoxide metabolic process  nitric oxide biosynthetic process  nitric oxide mediated signal transduction  circadian rhythm  response to bacterium  FMN binding  negative regulation of gene expression  peptidyl-cysteine S-nitrosylation  heme binding  cortical cytoskeleton  positive regulation of guanylate cyclase activity  prostaglandin secretion  tetrahydrobiopterin binding  arginine binding  cellular response to drug  regulation of cell proliferation  negative regulation of protein catabolic process  defense response to bacterium  defense response to bacterium  protein homodimerization activity  regulation of cellular respiration  cell redox homeostasis  negative regulation of blood pressure  positive regulation of vasodilation  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  NADP binding  regulation of insulin secretion  defense response to Gram-negative bacterium  positive regulation of killing of cells of other organism  oxidation-reduction process  cellular response to lipopolysaccharide  cellular response to interferon-gamma  interleukin-6 secretion  interleukin-8 secretion  regulation of cytokine production involved in inflammatory response  
Ontology : EGO-EBIresponse to hypoxia  positive regulation of leukocyte mediated cytotoxicity  innate immune response in mucosa  nitric-oxide synthase activity  nitric-oxide synthase activity  receptor binding  iron ion binding  protein binding  calmodulin binding  intracellular  nucleus  cytoplasm  peroxisome  cytosol  cytosol  arginine catabolic process  superoxide metabolic process  nitric oxide biosynthetic process  nitric oxide mediated signal transduction  circadian rhythm  response to bacterium  FMN binding  negative regulation of gene expression  peptidyl-cysteine S-nitrosylation  heme binding  cortical cytoskeleton  positive regulation of guanylate cyclase activity  prostaglandin secretion  tetrahydrobiopterin binding  arginine binding  cellular response to drug  regulation of cell proliferation  negative regulation of protein catabolic process  defense response to bacterium  defense response to bacterium  protein homodimerization activity  regulation of cellular respiration  cell redox homeostasis  negative regulation of blood pressure  positive regulation of vasodilation  perinuclear region of cytoplasm  flavin adenine dinucleotide binding  NADP binding  regulation of insulin secretion  defense response to Gram-negative bacterium  positive regulation of killing of cells of other organism  oxidation-reduction process  cellular response to lipopolysaccharide  cellular response to interferon-gamma  interleukin-6 secretion  interleukin-8 secretion  regulation of cytokine production involved in inflammatory response  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGArginine and proline metabolism    Calcium signaling pathway    HIF-1 signaling pathway    Peroxisome    Salmonella infection    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Amoebiasis    Tuberculosis    Pathways in cancer    Small cell lung cancer   
NDEx NetworkNOS2
Atlas of Cancer Signalling NetworkNOS2
Wikipedia pathwaysNOS2
Orthology - Evolution
OrthoDB4843
GeneTree (enSembl)ENSG00000007171
Phylogenetic Trees/Animal Genes : TreeFamNOS2
HOVERGENP35228
HOGENOMP35228
Homologs : HomoloGeneNOS2
Homology/Alignments : Family Browser (UCSC)NOS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNOS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NOS2
dbVarNOS2
ClinVarNOS2
1000_GenomesNOS2 
Exome Variant ServerNOS2
ExAC (Exome Aggregation Consortium)NOS2 (select the gene name)
Genetic variants : HAPMAP4843
Genomic Variants (DGV)NOS2 [DGVbeta]
DECIPHER (Syndromes)17:26083792-26127555  ENSG00000007171
CONAN: Copy Number AnalysisNOS2 
Mutations
ICGC Data PortalNOS2 
TCGA Data PortalNOS2 
Broad Tumor PortalNOS2
OASIS PortalNOS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNOS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNOS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch NOS2
DgiDB (Drug Gene Interaction Database)NOS2
DoCM (Curated mutations)NOS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NOS2 (select a term)
intoGenNOS2
Cancer3DNOS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM145500    163730    611162   
Orphanet
MedgenNOS2
Genetic Testing Registry NOS2
NextProtP35228 [Medical]
TSGene4843
GENETestsNOS2
Huge Navigator NOS2 [HugePedia]
snp3D : Map Gene to Disease4843
BioCentury BCIQNOS2
ClinGenNOS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4843
Chemical/Pharm GKB GenePA164724093
Clinical trialNOS2
Miscellaneous
canSAR (ICR)NOS2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNOS2
EVEXNOS2
GoPubMedNOS2
iHOPNOS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:29 CEST 2017

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