Identity
HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
HEP-NOS,INOS,NOS,NOS2A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4843
MIM: 163730
HGNC: 7873
Ensembl: ENSG00000007171
Variants:
dbSNP: 4843
ClinVar: 4843
TCGA: ENSG00000007171
COSMIC: NOS2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000007171 | ENST00000313735 | P35228 |
| ENSG00000007171 | ENST00000621962 | P35228 |
| ENSG00000007171 | ENST00000646938 | A0A2R8YDS4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164925725 | Toxic liver disease | Disease | ClinicalAnnotation | associated | PD | 22341855 | |
| PA445941 | Tuberculosis | Disease | ClinicalAnnotation | associated | PD | 22341855 | |
| PA449412 | doxorubicin | Chemical | Pathway | associated | 21048526 | ||
| PA449957 | ibuprofen | Chemical | Pathway | associated | 25502615 | ||
| PA450112 | isoniazid | Chemical | ClinicalAnnotation | associated | PD | 22341855 | |
| PA451250 | rifampin | Chemical | ClinicalAnnotation | associated | PD | 22341855 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37852325 | 2024 | NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells. | 1 |
| 38150896 | 2024 | Influence of microRNAs on iNOS expression in postmortem human infarction hearts. | 0 |
| 38583755 | 2024 | INOS ablation promotes corneal wound healing via activation of Akt signaling. | 0 |
| 37852325 | 2024 | NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells. | 1 |
| 38150896 | 2024 | Influence of microRNAs on iNOS expression in postmortem human infarction hearts. | 0 |
| 38583755 | 2024 | INOS ablation promotes corneal wound healing via activation of Akt signaling. | 0 |
| 36306210 | 2023 | Downregulation of iNOS/NO Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. | 4 |
| 36394557 | 2023 | No Association Between Interleukin 6 and Inducible Nitric Oxide Synthase Polymorphisms and Dengue Infection: A Case-Control Study. | 0 |
| 36716438 | 2023 | Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma. | 0 |
| 36833440 | 2023 | Association of Single-Nucleotide Polymorphisms Rs2779249 (chr17:26128581 C>A) and Rs rs2297518 (chr17: chr17:27769571 G>A) of the NOS2 Gene with Tension-Type Headache and Arterial Hypertension Overlap Syndrome in Eastern Siberia. | 1 |
| 36863485 | 2023 | Elevated iNOS and 3'-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model. | 4 |
| 37169743 | 2023 | Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome. | 6 |
| 37465758 | 2023 | Nitric oxide synthase 2 genetic variation rs2297514 associates with a decreased susceptibility to extremity post-traumatic osteomyelitis in a Chinese Han population. | 0 |
| 37486100 | 2023 | The expression levels of NOS2, HMOX1, and VEGFC in cumulus cells are markers of oocyte maturation and fertilization rate. | 2 |
| 37575057 | 2023 | Inducible nitric oxide synthase activity mediates TNF-α-induced endothelial cell dysfunction. | 2 |
Citation
Dessen P
NOS2 (nitric oxide synthase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41553/nos2
