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NPPA (natriuretic peptide A)

Identity

Alias_namesANP
PND
natriuretic peptide precursor A
Other aliasANF
ATFB6
ATRST2
CDD
CDD-ANF
CDP
HGNC (Hugo) NPPA
LocusID (NCBI) 4878
Atlas_Id 41567
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11905767 and ends at 11907840 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPPA   7939
LRG (Locus Reference Genomic)LRG_751
Cards
Entrez_Gene (NCBI)NPPA  4878  natriuretic peptide A
AliasesANF; ANP; ATFB6; ATRST2; 
CDD; CDD-ANF; CDP; PND
GeneCards (Weizmann)NPPA
Ensembl hg19 (Hinxton)ENSG00000175206 [Gene_View]  chr1:11905767-11907840 [Contig_View]  NPPA [Vega]
Ensembl hg38 (Hinxton)ENSG00000175206 [Gene_View]  chr1:11905767-11907840 [Contig_View]  NPPA [Vega]
ICGC DataPortalENSG00000175206
TCGA cBioPortalNPPA
AceView (NCBI)NPPA
Genatlas (Paris)NPPA
WikiGenes4878
SOURCE (Princeton)NPPA
Genetics Home Reference (NIH)NPPA
Genomic and cartography
GoldenPath hg19 (UCSC)NPPA  -     chr1:11905767-11907840 -  1p36.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NPPA  -     1p36.22   [Description]    (hg38-Dec_2013)
EnsemblNPPA - 1p36.22 [CytoView hg19]  NPPA - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBINPPA [Mapview hg19]  NPPA [Mapview hg38]
OMIM108780   612201   615745   
Gene and transcription
Genbank (Entrez)AA779538 BC005893 DQ893115 DQ896389 EU176780
RefSeq transcript (Entrez)NM_006172
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_012926 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)NPPA
Cluster EST : UnigeneHs.75640 [ NCBI ]
CGAP (NCI)Hs.75640
Alternative Splicing GalleryENSG00000175206
Gene ExpressionNPPA [ NCBI-GEO ]   NPPA [ EBI - ARRAY_EXPRESS ]   NPPA [ SEEK ]   NPPA [ MEM ]
Gene Expression Viewer (FireBrowse)NPPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4878
GTEX Portal (Tissue expression)NPPA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01160
Splice isoforms : SwissVarP01160
PhosPhoSitePlusP01160
Domaine pattern : Prosite (Expaxy)NATRIURETIC_PEPTIDE (PS00263)   
Domains : Interpro (EBI)Natr_peptide    Natr_peptide_CS    Natriuretic_peptide_atrial   
Domain families : Pfam (Sanger)ANP (PF00212)   
Domain families : Pfam (NCBI)pfam00212   
Domain families : Smart (EMBL)NAT_PEP (SM00183)  
Conserved Domain (NCBI)NPPA
DMDM Disease mutations4878
Blocks (Seattle)NPPA
PDB (SRS)1ANP    1YK0    3N57   
PDB (PDBSum)1ANP    1YK0    3N57   
PDB (IMB)1ANP    1YK0    3N57   
PDB (RSDB)1ANP    1YK0    3N57   
Structural Biology KnowledgeBase1ANP    1YK0    3N57   
SCOP (Structural Classification of Proteins)1ANP    1YK0    3N57   
CATH (Classification of proteins structures)1ANP    1YK0    3N57   
SuperfamilyP01160
Human Protein AtlasENSG00000175206
Peptide AtlasP01160
HPRD00164
IPIIPI00221279   IPI00644997   
Protein Interaction databases
DIP (DOE-UCLA)P01160
IntAct (EBI)P01160
FunCoupENSG00000175206
BioGRIDNPPA
STRING (EMBL)NPPA
ZODIACNPPA
Ontologies - Pathways
QuickGOP01160
Ontology : AmiGOresponse to hypoxia  negative regulation of systemic arterial blood pressure  receptor binding  receptor binding  neuropeptide hormone activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cGMP biosynthetic process  transcription initiation from RNA polymerase II promoter  receptor guanylyl cyclase signaling pathway  neuropeptide signaling pathway  female pregnancy  regulation of blood pressure  positive regulation of heart rate  cardiac muscle hypertrophy in response to stress  negative regulation of cell growth  response to insulin  response to muscle stretch  mast cell granule  cellular protein metabolic process  perinuclear region of cytoplasm  regulation of blood vessel size  peptide hormone receptor binding  regulation of atrial cardiac muscle cell membrane repolarization  positive regulation of cardiac muscle contraction  cell growth involved in cardiac muscle cell development  cellular response to mechanical stimulus  neuropeptide receptor binding  regulation of high voltage-gated calcium channel activity  positive regulation of delayed rectifier potassium channel activity  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  positive regulation of potassium ion export across plasma membrane  regulation of cardiac conduction  negative regulation of collecting lymphatic vessel constriction  
Ontology : EGO-EBIresponse to hypoxia  negative regulation of systemic arterial blood pressure  receptor binding  receptor binding  neuropeptide hormone activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  cGMP biosynthetic process  transcription initiation from RNA polymerase II promoter  receptor guanylyl cyclase signaling pathway  neuropeptide signaling pathway  female pregnancy  regulation of blood pressure  positive regulation of heart rate  cardiac muscle hypertrophy in response to stress  negative regulation of cell growth  response to insulin  response to muscle stretch  mast cell granule  cellular protein metabolic process  perinuclear region of cytoplasm  regulation of blood vessel size  peptide hormone receptor binding  regulation of atrial cardiac muscle cell membrane repolarization  positive regulation of cardiac muscle contraction  cell growth involved in cardiac muscle cell development  cellular response to mechanical stimulus  neuropeptide receptor binding  regulation of high voltage-gated calcium channel activity  positive regulation of delayed rectifier potassium channel activity  regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  positive regulation of potassium ion export across plasma membrane  regulation of cardiac conduction  negative regulation of collecting lymphatic vessel constriction  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]    Corticosteroids and cardioprotection [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]   
Pathways : KEGGHIF-1 signaling pathway   
NDEx NetworkNPPA
Atlas of Cancer Signalling NetworkNPPA
Wikipedia pathwaysNPPA
Orthology - Evolution
OrthoDB4878
GeneTree (enSembl)ENSG00000175206
Phylogenetic Trees/Animal Genes : TreeFamNPPA
HOVERGENP01160
HOGENOMP01160
Homologs : HomoloGeneNPPA
Homology/Alignments : Family Browser (UCSC)NPPA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPPA
dbVarNPPA
ClinVarNPPA
1000_GenomesNPPA 
Exome Variant ServerNPPA
ExAC (Exome Aggregation Consortium)NPPA (select the gene name)
Genetic variants : HAPMAP4878
Genomic Variants (DGV)NPPA [DGVbeta]
DECIPHER (Syndromes)1:11905767-11907840  ENSG00000175206
CONAN: Copy Number AnalysisNPPA 
Mutations
ICGC Data PortalNPPA 
TCGA Data PortalNPPA 
Broad Tumor PortalNPPA
OASIS PortalNPPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPPA
DgiDB (Drug Gene Interaction Database)NPPA
DoCM (Curated mutations)NPPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPPA (select a term)
intoGenNPPA
Cancer3DNPPA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108780    612201    615745   
Orphanet982    8592   
MedgenNPPA
Genetic Testing Registry NPPA
NextProtP01160 [Medical]
TSGene4878
GENETestsNPPA
Huge Navigator NPPA [HugePedia]
snp3D : Map Gene to Disease4878
BioCentury BCIQNPPA
ClinGenNPPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4878
Chemical/Pharm GKB GenePA256
Clinical trialNPPA
Miscellaneous
canSAR (ICR)NPPA (select the gene name)
Probes
Litterature
PubMed225 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPPA
EVEXNPPA
GoPubMedNPPA
iHOPNPPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:19:14 CET 2017

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