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NPRL2 (NPR2-like, GATOR1 complex subunit)

Identity

Alias_namesTUSC4
tumor suppressor candidate 4
nitrogen permease regulator-like 2 (S. cerevisiae)
Alias_symbol (synonym)NPR2L
NPR2
Other aliasFFEVF2
HGNC (Hugo) NPRL2
LocusID (NCBI) 10641
Atlas_Id 51431
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 50347488 and ends at 50351055 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NPRL2 (3p21.31) / NPRL2 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NPRL2   24969
Cards
Entrez_Gene (NCBI)NPRL2  10641  NPR2-like, GATOR1 complex subunit
AliasesFFEVF2; NPR2; NPR2L; TUSC4
GeneCards (Weizmann)NPRL2
Ensembl hg19 (Hinxton)ENSG00000114388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114388 [Gene_View]  chr3:50347488-50351055 [Contig_View]  NPRL2 [Vega]
ICGC DataPortalENSG00000114388
TCGA cBioPortalNPRL2
AceView (NCBI)NPRL2
Genatlas (Paris)NPRL2
WikiGenes10641
SOURCE (Princeton)NPRL2
Genetics Home Reference (NIH)NPRL2
Genomic and cartography
GoldenPath hg38 (UCSC)NPRL2  -     chr3:50347488-50351055 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPRL2  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblNPRL2 - 3p21.31 [CytoView hg19]  NPRL2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBINPRL2 [Mapview hg19]  NPRL2 [Mapview hg38]
OMIM607072   617116   
Gene and transcription
Genbank (Entrez)AF040707 AF040708 AK098161 AK292196 AK309658
RefSeq transcript (Entrez)NM_006545
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NPRL2
Cluster EST : UnigeneHs.437083 [ NCBI ]
CGAP (NCI)Hs.437083
Alternative Splicing GalleryENSG00000114388
Gene ExpressionNPRL2 [ NCBI-GEO ]   NPRL2 [ EBI - ARRAY_EXPRESS ]   NPRL2 [ SEEK ]   NPRL2 [ MEM ]
Gene Expression Viewer (FireBrowse)NPRL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10641
GTEX Portal (Tissue expression)NPRL2
Human Protein AtlasENSG00000114388-NPRL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WTW4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WTW4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WTW4
Splice isoforms : SwissVarQ8WTW4
PhosPhoSitePlusQ8WTW4
Domains : Interpro (EBI)NPR2   
Domain families : Pfam (Sanger)NPR2 (PF06218)   
Domain families : Pfam (NCBI)pfam06218   
Conserved Domain (NCBI)NPRL2
DMDM Disease mutations10641
Blocks (Seattle)NPRL2
SuperfamilyQ8WTW4
Human Protein Atlas [tissue]ENSG00000114388-NPRL2 [tissue]
Peptide AtlasQ8WTW4
HPRD06147
IPIIPI00410108   IPI00383701   IPI00927392   IPI00926964   
Protein Interaction databases
DIP (DOE-UCLA)Q8WTW4
IntAct (EBI)Q8WTW4
FunCoupENSG00000114388
BioGRIDNPRL2
STRING (EMBL)NPRL2
ZODIACNPRL2
Ontologies - Pathways
QuickGOQ8WTW4
Ontology : AmiGOprotein kinase activity  GTPase activator activity  protein binding  lysosomal membrane  vacuole  protein phosphorylation  cellular response to nitrogen starvation  positive regulation of autophagy  negative regulation of TOR signaling  negative regulation of kinase activity  cellular response to amino acid starvation  positive regulation of GTPase activity  GATOR1 complex  regulation of autophagosome assembly  
Ontology : EGO-EBIprotein kinase activity  GTPase activator activity  protein binding  lysosomal membrane  vacuole  protein phosphorylation  cellular response to nitrogen starvation  positive regulation of autophagy  negative regulation of TOR signaling  negative regulation of kinase activity  cellular response to amino acid starvation  positive regulation of GTPase activity  GATOR1 complex  regulation of autophagosome assembly  
NDEx NetworkNPRL2
Atlas of Cancer Signalling NetworkNPRL2
Wikipedia pathwaysNPRL2
Orthology - Evolution
OrthoDB10641
GeneTree (enSembl)ENSG00000114388
Phylogenetic Trees/Animal Genes : TreeFamNPRL2
HOVERGENQ8WTW4
HOGENOMQ8WTW4
Homologs : HomoloGeneNPRL2
Homology/Alignments : Family Browser (UCSC)NPRL2
Gene fusions - Rearrangements
Tumor Fusion PortalNPRL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPRL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPRL2
dbVarNPRL2
ClinVarNPRL2
1000_GenomesNPRL2 
Exome Variant ServerNPRL2
ExAC (Exome Aggregation Consortium)ENSG00000114388
GNOMAD BrowserENSG00000114388
Genetic variants : HAPMAP10641
Genomic Variants (DGV)NPRL2 [DGVbeta]
DECIPHERNPRL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPRL2 
Mutations
ICGC Data PortalNPRL2 
TCGA Data PortalNPRL2 
Broad Tumor PortalNPRL2
OASIS PortalNPRL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPRL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNPRL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NPRL2
DgiDB (Drug Gene Interaction Database)NPRL2
DoCM (Curated mutations)NPRL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NPRL2 (select a term)
intoGenNPRL2
Cancer3DNPRL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607072    617116   
Orphanet
DisGeNETNPRL2
MedgenNPRL2
Genetic Testing Registry NPRL2
NextProtQ8WTW4 [Medical]
TSGene10641
GENETestsNPRL2
Target ValidationNPRL2
Huge Navigator NPRL2 [HugePedia]
snp3D : Map Gene to Disease10641
BioCentury BCIQNPRL2
ClinGenNPRL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10641
Chemical/Pharm GKB GenePA165697981
Clinical trialNPRL2
Miscellaneous
canSAR (ICR)NPRL2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNPRL2
EVEXNPRL2
GoPubMedNPRL2
iHOPNPRL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:26:39 CET 2017

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