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NPRL2 (NPR2 like, GATOR1 complex subunit)

Identity

Alias (NCBI)FFEVF2
NPR2
NPR2L
TUSC4
HGNC (Hugo) NPRL2
HGNC Alias symbNPR2L
NPR2
HGNC Previous nameTUSC4
HGNC Previous nametumor suppressor candidate 4
 nitrogen permease regulator-like 2 (S. cerevisiae)
LocusID (NCBI) 10641
Atlas_Id 51431
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 50347355 and ends at 50350775 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NPRL2 (3p21.31) / NPRL2 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NPRL2   24969
Cards
Entrez_Gene (NCBI)NPRL2    NPR2 like, GATOR1 complex subunit
AliasesFFEVF2; NPR2; NPR2L; TUSC4
GeneCards (Weizmann)NPRL2
Ensembl hg19 (Hinxton)ENSG00000114388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114388 [Gene_View]  ENSG00000114388 [Sequence]  chr3:50347355-50350775 [Contig_View]  NPRL2 [Vega]
ICGC DataPortalENSG00000114388
TCGA cBioPortalNPRL2
AceView (NCBI)NPRL2
Genatlas (Paris)NPRL2
SOURCE (Princeton)NPRL2
Genetics Home Reference (NIH)NPRL2
Genomic and cartography
GoldenPath hg38 (UCSC)NPRL2  -     chr3:50347355-50350775 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NPRL2  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathNPRL2 - 3p21.31 [CytoView hg19]  NPRL2 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000114388
Genome Data Viewer NCBINPRL2 [Mapview hg19]  
OMIM607072   617116   
Gene and transcription
Genbank (Entrez)AF040707 AF040708 AK098161 AK292196 AK309658
RefSeq transcript (Entrez)NM_006545
Consensus coding sequences : CCDS (NCBI)NPRL2
Gene ExpressionNPRL2 [ NCBI-GEO ]   NPRL2 [ EBI - ARRAY_EXPRESS ]   NPRL2 [ SEEK ]   NPRL2 [ MEM ]
Gene Expression Viewer (FireBrowse)NPRL2 [ Firebrowse - Broad ]
GenevisibleExpression of NPRL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10641
GTEX Portal (Tissue expression)NPRL2
Human Protein AtlasENSG00000114388-NPRL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WTW4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WTW4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WTW4
PhosPhoSitePlusQ8WTW4
Domains : Interpro (EBI)NPR2   
Domain families : Pfam (Sanger)NPR2 (PF06218)   
Domain families : Pfam (NCBI)pfam06218   
Conserved Domain (NCBI)NPRL2
PDB (RSDB)6CES    6CET   
PDB Europe6CES    6CET   
PDB (PDBSum)6CES    6CET   
PDB (IMB)6CES    6CET   
Structural Biology KnowledgeBase6CES    6CET   
SCOP (Structural Classification of Proteins)6CES    6CET   
CATH (Classification of proteins structures)6CES    6CET   
SuperfamilyQ8WTW4
AlphaFold pdb e-kbQ8WTW4   
Human Protein Atlas [tissue]ENSG00000114388-NPRL2 [tissue]
HPRD06147
Protein Interaction databases
DIP (DOE-UCLA)Q8WTW4
IntAct (EBI)Q8WTW4
BioGRIDNPRL2
STRING (EMBL)NPRL2
ZODIACNPRL2
Ontologies - Pathways
QuickGOQ8WTW4
Ontology : AmiGOprotein kinase activity  GTPase activator activity  protein binding  lysosomal membrane  lysosomal membrane  protein phosphorylation  cellular response to nitrogen starvation  positive regulation of autophagy  negative regulation of TOR signaling  negative regulation of TOR signaling  negative regulation of kinase activity  cellular response to amino acid starvation  cellular response to amino acid starvation  cellular response to amino acid starvation  GATOR1 complex  GATOR1 complex  regulation of autophagosome assembly  
Ontology : EGO-EBIprotein kinase activity  GTPase activator activity  protein binding  lysosomal membrane  lysosomal membrane  protein phosphorylation  cellular response to nitrogen starvation  positive regulation of autophagy  negative regulation of TOR signaling  negative regulation of TOR signaling  negative regulation of kinase activity  cellular response to amino acid starvation  cellular response to amino acid starvation  cellular response to amino acid starvation  GATOR1 complex  GATOR1 complex  regulation of autophagosome assembly  
NDEx NetworkNPRL2
Atlas of Cancer Signalling NetworkNPRL2
Wikipedia pathwaysNPRL2
Orthology - Evolution
OrthoDB10641
GeneTree (enSembl)ENSG00000114388
Phylogenetic Trees/Animal Genes : TreeFamNPRL2
Homologs : HomoloGeneNPRL2
Homology/Alignments : Family Browser (UCSC)NPRL2
Gene fusions - Rearrangements
Fusion : QuiverNPRL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNPRL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NPRL2
dbVarNPRL2
ClinVarNPRL2
MonarchNPRL2
1000_GenomesNPRL2 
Exome Variant ServerNPRL2
GNOMAD BrowserENSG00000114388
Varsome BrowserNPRL2
ACMGNPRL2 variants
VarityQ8WTW4
Genomic Variants (DGV)NPRL2 [DGVbeta]
DECIPHERNPRL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNPRL2 
Mutations
ICGC Data PortalNPRL2 
TCGA Data PortalNPRL2 
Broad Tumor PortalNPRL2
OASIS PortalNPRL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNPRL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNPRL2
Mutations and Diseases : HGMDNPRL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNPRL2
DgiDB (Drug Gene Interaction Database)NPRL2
DoCM (Curated mutations)NPRL2
CIViC (Clinical Interpretations of Variants in Cancer)NPRL2
Cancer3DNPRL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607072    617116   
Orphanet
DisGeNETNPRL2
MedgenNPRL2
Genetic Testing Registry NPRL2
NextProtQ8WTW4 [Medical]
GENETestsNPRL2
Target ValidationNPRL2
Huge Navigator NPRL2 [HugePedia]
ClinGenNPRL2
Clinical trials, drugs, therapy
MyCancerGenomeNPRL2
Protein Interactions : CTDNPRL2
Pharm GKB GenePA165697981
PharosQ8WTW4
Clinical trialNPRL2
Miscellaneous
canSAR (ICR)NPRL2
HarmonizomeNPRL2
DataMed IndexNPRL2
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNPRL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:23:11 CEST 2021

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